Browsing by Author "Budishevska, Olha"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Ionically and covalently crosslinked hydrogel particles based on chitosan and poly(ethylene glycol)
    (Publishing House of Lviv Polytechnic National University, 2014) Popadyuk, Nadiya; Zholobko, Oksana; Donchak, Volodymyr; Harhay, Khrystyna; Budishevska, Olha; Voronov, Andriy; Kohut, Ananiy; Voronov, Stanislav
    Self-assembled pH-sensitive reactive submicron-sized particles have been developed via intermolecular electrostatic interactions between chitosan and a carboxylated oligoperoxide having poly(ethylene glycol) fragments. The particles have the structure of an ionically crosslinked hydrogel and their size and surface charge depend on the conditions of their formation (i.e., pH and the functional group ratio). The presence of peroxide groups in the oligoperoxide has enabled to synthesize covalently crosslinked pH-sensitive particles. Електростатичною міжмолекулярною взаємодією хітозану та карбоксиловмісного олігопероксиду з фрагментами поліетиленгліколю одержані самовпорядковані рН-чутливі реакційноздатні субмікронні частинки, які мають структуру йонно-зшитого гідрогелю, а їх розмір та поверхневий заряд залежить від умов формування (рН і співвідношення функціональних груп). Наявність пероксидних груп у складі олігопероксиду дала можливість одержати ковалентно зшиті рН-чутливі частинки.
  • Thumbnail Image
    Item
    Polyoxyethylene containing chitosan derivatives for the development of hydrogels
    (Видавництво Львівської політехніки, 2013) Zholobko, Oksana; Tarnavchyk, Igor; Demchuk, Zoriana; Voronov, Andriy; Budishevska, Olha; Voronov, Stanislav
    Polyoxyethylene containing derivatives of succinic acid (2SA-PEG) have been synthesized via the acylation of polyethylene glycols with succinic anhydride. Water-soluble chitosan derivatives and films based on them have been obtained through the interaction between 2SA-PEG and chitosan (CS). Water-insoluble films have been developed via crosslinking during thermal treatment of the products of the interaction between 2SA-PEG and chitosan. The films form hydrogels after swelling in water. The hydrogel films, filled with rhodamine G and malachite green dyes, are capable of prolonged releasing them into an aqueous medium.