Browsing by Author "Sosnowski, Tomasz R."

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Characteristics of spray drying process of nanocolloidal silica as a method of production of nanostructural powders potentially applicable in inhalation therapy
(Lviv Polytechnic Publishing House, 2015) Jabłczyńska, Katarzyna; Wojnarowicz, Michał; Sosnowski, Tomasz R.; Warsaw University of Technology
The research was focused on investigations of the impact of spray-drying (SD) conditions on the morphology and aerosol performance of powders produced from nanocolloidal silica. Microsized nanostructiral particles were characterized by SEM, aerosol spectrometry and pharmaceutical impactor. Results show that proper adjusting of SD process parameters and precursor composition allows to obtain powders of different morphologies: solid or hollow particles with different wall thickness, or particles with a microporous structure with spherical or nonspherical shape. Obtained results indicate that silica nanoagreggates have characteristics suitable for their effective delivery to the lungs via inhalation.
Effect of diesel-emitted nanostructured particles on the apparent surface rheology of model lung surfactant
(Lviv Polytechnic Publishing House, 2016) Sosnowski, Tomasz R.; Penconek, Agata; Jabłczyńska, Katarzyna; Warsaw University of Technology
Diesel exhaust contain nanostructured particles which may be inhaled and may interact with the lung surfactant (LS) present in the respiratory system. This work reports the experimental analysis of surface tension variations in model LS system which contain diesel exhaust particles (DEPs). Experiments of oscillatory deformations of air/liquid interface under physiological-like conditions allowed to determine the changes in apparent surface rheological parameters, which indicated evident alteration of mechanical properties of LS caused by DEPs. These results allow to speculate on possible adverse effects of inhaled DEPs on LS in vivo.
Preparation of nanostructural dextran-based carrier particles for drug delivery to the lungs
(Lviv Polytechnic Publishing House, 2016) Jabłczyńska, Katarzyna; Widyńska, Ewelina; Sosnowski, Tomasz R.; Warsaw University of Technology
Particle engineering can be used to design inhalation drug carrier that will combine advantages of nano- and microparticles. This work present a review of research on dextran-based nanostructural powder prepared using the spray drying method. The shape of powder particles is shown to depend on the applied drying process parameters and additives used. It was proved that surface morphology of particles strongly affects powder aerosolization performance. Tested powders demonstrated a good restoration of the initial nanoparticles size distribution after rehydration. All these features allow to consider dextran-based nanostructural particles as new attractive carriers for drug delivery to the lungs.