Browsing by Author "Stasiuk, Anna"

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    Esterification of dextrine by the N-derivatives of glutamic acid using steglich reaction
    (Видавництво Львівської політехніки, 2017-12-23) Nagorniak, Mikhailo; Oleksa, Victoria; Dron, Iryna; Stasiuk, Anna; Maikovich, Olha; Bordeniuk, Olena; Lviv Polytechnic National University
    Was investigated the esterification of dextrin using Steglich reaction. Such modification allows obtaining a functional product with an extensive structure of macromolecules, capable to form self-stabilized dispersions in an aqueous environment. To ensure the branching, the modification was performed using the functional agents – Nderivatives of glutamic acid. The substitute in the N-position provides the introduction of the required function.
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    Poly(ethylene glycol) and poly(propylene glycol)-containing aminofunctional copolyesters for biomedical application
    (Lviv Polytechnic Publishing House, 2016) Voronovska, Anna; Tovarnitskyi, Andrii; Zelenyak, Oresta; Ranevska, Myroslava; Stasiuk, Anna; Ferens, Mariia; Fihurka, Nataliia; Tarnavchyk, Ihor; Lviv Polytechnic National University; North Dakota State University
    Polyesters (pseudo-poly(amino acids) based on the dicarboxilic amino acids and diols of different molecular weight (polyethylene glycols with polycondensation degree of 2-8) were synthesized using N,N′-dicyclo-hexyl-carbodiimide (DCC) – the activator of carboxyl grous. Also were synthesized the novel amphiphilic polyesterethers based on natural dibasic amino acids including their N-derivatives with controllable colloidal properties and ionogenic groups of cationic type (amino groups). The complex of properties (amphiphilicity, biodegradability and non-toxic degradation of the products) and the ability to form self-assembled structures in aqueous environment allow to use such polymers to form in vivo delivery systems.
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    Synthesis and Properties of Phosphorus-Containing Pseudo-Poly(Amino Acid)sof Polyester Type Based on N-Derivatives of Glutaminic Acid
    (Видавництво Львівської політехніки, 2022-03-16) Stasiuk, Anna; Fihurka, Nataliia; Vlizlo, Vasyl; Prychak, Sofiia; Ostapiv, Dmytro; Varvarenko, Serhii; Samaryk, Volodymyr; Lviv Polytechnic National University; Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies; Institute of Animal Biology NAAS
    Поліфосфоестери (ПФЕ) – це клас полімерів, що володіють високою хімічною функціональністю та здатністю до біологічного розкладання. Синтезовані нові поліфосфоестери на основі глутамінової кислоти за реакцією Стегліха. Розроблений синтетичний підхід дозволяє контролювати склад і структуру ПФЕ, а отже, їхфізичні та колоїдні властивості. Дослідження солюбілізації та цитотоксичності in vitro довели потенціал застосування ПФЕ для доставки лікарських препаратів.