Ukrainian Journal of Mechanical Engineering and Materials Science. – 2023. – Vol. 9, No. 3

Permanent URI for this collectionhttps://ena.lpnu.ua/handle/ntb/61632

Науковий журнал

Засновник і видавець Національний університет «Львівська політехніка». Виходить двічі на рік з 2015 року.

Ukrainian Journal of Mechanical Engineering and Materials Science = Український журнал із машинобудування і матеріалознавства : науковий журнал / Lviv Politechnic National University ; editor-in-chief Oleksiy Lanets . – Lviv : Lviv Politechnic Publishing House, 2023. – Volume 9, number 3. – 73 p.

Український журнал із машинобудування і матеріалознавства

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    Optimization of oligonucleotides characteristics with topsis
    (Видавництво Львівської політехніки, 2023-02-28) Javanbakht, Taraneh; Concordia University
    This paper focused on a new application of the TOPSIS method for the prediction and optimization of the oligonucleotides characteristics. This method has been used for these purposes as it has shown its efficacy for these analyses. This is the first time that it has been applied to the investigation of these biomolecules. The hypothesis in this paper was that the characteristics of these biomaterials would be optimized according to their structural differences. The obtained results showed that the stabilization of oligonucleotides would affect their ranking with TOPSIS when the stability of these biomolecules increased against enzymes in their structure. In other words, the oligonucleotides with less enzymatic degradation were ranked better with this method. This study showed the first application of this algorithm for the prediction and optimization of the oligonucleotides’ characteristics. The results in this work revealed that the ranks of candidates depended on their distances from their ideal solutions. This showed that TOPSIS could be used as an appropriate method in the optimization of oligonucleotides as the rankings with this method would coincide with the data that concern the stability of these biomolecules against enzymatic degradation. The results of this work could be applied for the preparation of novel materials with applications in science and engineering.