Хімія та хімічні технології
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Item Synthesis of new heterocyclic compounds based on 1,4-naphthoquinones and azomethines of α-amino acids(Видавництво Львівської політехніки, 2013) Kudrinetska, Anastasiia; Shakh, Yurii; Bolibrukh, Khrystyna; Karkhut, Andrii; Lytvyn, Bohdan; Polovkovych, SviatoslavAnalysed the literature sources to establish the basic ˝skafolds ˝, necessary for the design of "drugs-like molecules." Created the combinatorial library of new heterocyclic derivatives of 1,4-naphthoquinone. A docking study for determining structure leaders was conducted, ways of optimization the chemical structures to enhance the biological activity were determined. Designed by methods of obtaining a new heterocyclic derivatives based on 1,4-naphthoquinone and conducted search including effective anti-cancer agents.