Розробка складу присипки з тіосульфонатною складовою (ААТС) та вивчення її протимікробної дії

Simple item page
dc.citation.epage139
dc.citation.issue7
dc.citation.journalTitleХімія, технологія речовин та їх застосування
dc.citation.spage131
dc.citation.volume1
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.authorФізер, Л. В.
dc.contributor.authorПаращин, Ж. Д.
dc.contributor.authorКомаровська-Порохнявець, О. З.
dc.contributor.authorЛубенець, В. І.
dc.contributor.authorFizer, L. V.
dc.contributor.authorParashchyn, Zh. D.
dc.contributor.authorKomarovska-Porokhnyavets, O. Z.
dc.contributor.authorLubenets, V. I.
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2025-09-12T07:59:47Z
dc.date.created2024-02-27
dc.date.issued2024-02-27
dc.description.abstractНаведено результати досліджень із розроблення складу потенційного лікарського засобу із S-етиловим естером 4-ацетиламінобензентіосульфокислоти для нашкірного застосування у формі присипки. Склад присипки обґрунтовано на основі мікробіологічних досліджень введеної сполуки і лікарської форми на її основі. Встановлено раціональний вміст сполуки як біологічно активної речовини у складі присипки та підібрано оптимальний склад допоміжних компонентів. Отримані експериментальні дані мікробіологічних досліджень свідчать про наявність специфічної антибактеріальної та протигрибкової активності присипки.
dc.description.abstractThe paper presents the results of research on the development of a potential drug that consists of Sethyl ester of 4-acetylaminobenzene sulfonic acid and excipients in the powder dosage form for topical use. The powder composition was substantiated on the basis of microbiological studies of the introduced compound and the dosage form based on it. The rational content of the compound as a biologically active substance in the powder was established. The optimal composition of excipients was selected. The obtained experimental data of microbiological studies indicate the presence of specific antibacterial and antifungal activity of the powder.
dc.format.extent131-139
dc.format.pages9
dc.identifier.citationРозробка складу присипки з тіосульфонатною складовою (ААТС) та вивчення її протимікробної дії / Л. В. Фізер, Ж. Д. Паращин, О. З. Комаровська-Порохнявець, В. І. Лубенець // Хімія, технологія речовин та їх застосування. — Львів : Видавництво Львівської політехніки, 2024. — Том 1. — № 7. — С. 131–139.
dc.identifier.citationenDevelopment of the powder composition with thiosulfonate component and study of its antimicrobial effect / L. V. Fizer, Zh. D. Parashchyn, O. Z. Komarovska-Porokhnyavets, V. I. Lubenets // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2024. — Vol 1. — No 7. — P. 131–139.
dc.identifier.doidoi.org/10.23939/ctas2024.01.131
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/111736
dc.language.isouk
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofХімія, технологія речовин та їх застосування, 7 (1), 2024
dc.relation.ispartofChemistry, Technology and Application of Substances, 7 (1), 2024
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dc.relation.references3. Robbins, N., Caplan, T., & Cowen, L. E. (2017). Molecular Evolution of Antifungal Drug Resistance. Annual review of microbiology, 71, 753-775. https://doi.org/10.1146/annurev-micro-030117-020345
dc.relation.references4. Arzanlou, M., Chai, W. C., & Venter, H. (2017). Intrinsic, adaptive and acquired antimicrobial resistance in Gram-negative bacteria. Essays in biochemistry, 61(1), 49-59. https://doi.org/10.1042/EBC20160063
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dc.relation.references11. Lubenets, V., Stadnytska, N., Baranovych, D., Vasylyuk, S., Karpenko, O., Havryliak, V., & Novikov, V. (2019). Thiosulfonates: The Prospective Substances against Fungal Infections. Fungal Infection. https://doi.org/10.5772/intechopen.84436
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dc.relation.references15. D'Amico, F., Casalino, G., Dinardo, F. R., Schiavitto, M., Camarda, A., Romito, D., Bove, A., & Circella, E. (2023). Antimicrobial Efficacy of Phyto-L, Thiosulfonate from Allium spp. Containing Supplement, against Escherichia Coli Strains from Rabbits. Veterinary sciences, 10(7), 411. https://doi.org/10.3390/vetsci10070411;
dc.relation.references16. Aiken, A. M., Allegranzi, B., Scott, J. A., Mehtar, S., Pittet, D., & Grundmann, H. (2014). Antibiotic resistance needs global solutions. The Lancet. Infectious diseases, 14(7), 550-551. https://doi.org/10.1016/S1473-3099(14)70709-1 Lubenets, V., Vasylyuk, S., Monka, N., Bolibrukh, K., Komarovska-Porokhnyavets, O., Baranovych, D., Musyanovych, R., Zaczynska, E., Czarny, A., Nawrot, U., & Novikov, V. (2017). Synthesis and antimicrobial properties of 4-acylaminobenzenethiosulfoacid S-esters. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 25(2), 266-274. https://doi.org/10.1016/j.jsps.2016.06.007
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dc.relation.references21. Rybachuk, V. D., Ruban, O., & Filimonova, N. (2019). Microbiological justification for the choice of antimicrobic substances concentration in powder composition based on natural zeolite (clinoptyololite). Ukraïns'kij Bìofarmacevtičnij Žurnal, 0(1(58)), 4-9. https://doi.org/10.24959/ubphj.19.196
dc.relation.references22. Kryshchyshyn, A. P., Kaminskyy, D. V., & Lesyk, R. B. (2015). Creation of innovative drugs (approaches and methodology of drug design) - one of the main issues of the modern pharmaceutical education. Journal of Organic and Pharmaceutical Chemistry, 13(1(49)), 49-58. https://doi.org/10.24959/ophcj.15.833
dc.relation.references23. Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2012). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews, 64, 4-17. https://doi.org/10.1016/j.addr.2012.09.019
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dc.relation.references26. Kopak, N. A. (2023). Searching of biological activity of s-esters 4- acetylaminobenzenethiosulfoacid using methods of chemoinformatics. Chemistry, Technology and Application of Substances, 6(2), 76-86. https://doi.org/10.23939/ctas2023.02.076.
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dc.relation.references28. Sposib oderzhannya tiosulʹfonatnoyi substantsiyi. № 153357/ zayavn. Natsionalʹnyy universytet "Lʹvivsʹka politekhnika".-u202204890; zayavl. 20.12.2022; opubl. 21.06.2023; byul. № 25. Lubenetsʹ V. I., Fizer L. V., Zvarych V.I., Monʹka N.YA.
dc.relation.references29. Escribano, P., & Guinea, J. (2022). Fluconazole-resistant Candida parapsilosis: A new emerging threat in the fungi arena. Frontiers in fungal biology, 3, 1010782. https://doi.org/10.3389/ffunb.2022.1010782.
dc.relation.referencesen1. Spivak, E. S., & Hanson, K. E. (2018). Candida auris: an Emerging Fungal Pathogen. Journal of clinical microbiology, 56(2), e01588-17. https://doi.org/10.1128/JCM.01588-17
dc.relation.referencesen2. Perlin, D. S., Rautemaa-Richardson, R., & Alastruey-Izquierdo, A. (2017). The global problem of antifungal resistance: prevalence, mechanisms, and management. The Lancet. Infectious diseases, 17(12), e383-e392. https://doi.org/10.1016/S1473-3099(17)30316-X
dc.relation.referencesen3. Robbins, N., Caplan, T., & Cowen, L. E. (2017). Molecular Evolution of Antifungal Drug Resistance. Annual review of microbiology, 71, 753-775. https://doi.org/10.1146/annurev-micro-030117-020345
dc.relation.referencesen4. Arzanlou, M., Chai, W. C., & Venter, H. (2017). Intrinsic, adaptive and acquired antimicrobial resistance in Gram-negative bacteria. Essays in biochemistry, 61(1), 49-59. https://doi.org/10.1042/EBC20160063
dc.relation.referencesen5. Baran, A., Kwiatkowska, A., & Potocki, L. (2023). Antibiotics and Bacterial Resistance-A Short Story of an Endless Arms Race. Internationaljournalofmolecular sciences, 24(6), 5777. https://doi.org/10.3390/ijms24065777
dc.relation.referencesen6. Aiken, A. M., Allegranzi, B., Scott, J. A., Mehtar, S., Pittet, D., & Grundmann, H. (2014). Antibiotic resistance needs global solutions. The Lancet. Infectious diseases, 14(7), 550-551. https://doi.org/10.1016/S1473-3099(14)70709-1
dc.relation.referencesen7. Aslam, B., Wang, W., Arshad, M. I., Khurshid, M., Muzammil, S., Rasool, M. H., Nisar, M. A., Alvi, R. F., Aslam, M. A., Qamar, M. U., Salamat, M. K. F., & Baloch, Z. (2018). Antibiotic resistance: a rundown of a global crisis. Infection and drug resistance, 11, 1645-1658. https://doi.org/10.2147/IDR.S173867
dc.relation.referencesen8. Hutchings, M. I., Truman, A. W., & Wilkinson, B. (2019). Antibiotics: past, present and future. Current opinion in microbiology, 51, 72-80. https://doi.org/10.1016/j.mib.2019.10.008
dc.relation.referencesen9. Bilyayeva, O. O., Kryzhevsʹkyy, YE. YE., & Karolʹ, I. V. (2017). Osoblyvosti vydovoho skladu zbudnykiv hniyno-zapalʹnykh zakhvoryuvanʹ mʺyakykh tkanyn. Ukrayinsʹkyy medychnyy chasopys, 3 (119), 1-3;
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dc.relation.referencesen11. Lubenets, V., Stadnytska, N., Baranovych, D., Vasylyuk, S., Karpenko, O., Havryliak, V., & Novikov, V. (2019). Thiosulfonates: The Prospective Substances against Fungal Infections. Fungal Infection. https://doi.org/10.5772/intechopen.84436
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dc.relation.referencesen13. Zaczynska, E., Czarny, A., Karpenko, L., Vasylyuk, S., Monka, N., Stadnytska, N., Fizer, L., Komarovska- Porokhnyavets, O., Jaranowski, M., Lubenets, V., & Zimecki, M. (2023). Obtaining and Determining Antiviral and Antibacterial Activity of S-Esters of 4-R-Aminobenzenethiosulfonic Acid. Chemistry & Chemical Technology, 17(2), 315-324. https://doi.org/10.23939/chcht17.02.315
dc.relation.referencesen14. Guillamón, E., Mut-Salud, N., Rodríguez-Sojo, M. J., Ruiz-Malagón, A. J., Cuberos-Escobar, A., Martínez- Férez, A., Rodríguez-Nogales, A., Gálvez, J., & Baños, A. (2023). In Vitro Antitumor and Anti- Inflammatory Activities of Allium-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS). Nutrients, 15(6), 1363. https://doi.org/10.3390/nu15061363;
dc.relation.referencesen15. D'Amico, F., Casalino, G., Dinardo, F. R., Schiavitto, M., Camarda, A., Romito, D., Bove, A., & Circella, E. (2023). Antimicrobial Efficacy of Phyto-L, Thiosulfonate from Allium spp. Containing Supplement, against Escherichia Coli Strains from Rabbits. Veterinary sciences, 10(7), 411. https://doi.org/10.3390/vetsci10070411;
dc.relation.referencesen16. Aiken, A. M., Allegranzi, B., Scott, J. A., Mehtar, S., Pittet, D., & Grundmann, H. (2014). Antibiotic resistance needs global solutions. The Lancet. Infectious diseases, 14(7), 550-551. https://doi.org/10.1016/S1473-3099(14)70709-1 Lubenets, V., Vasylyuk, S., Monka, N., Bolibrukh, K., Komarovska-Porokhnyavets, O., Baranovych, D., Musyanovych, R., Zaczynska, E., Czarny, A., Nawrot, U., & Novikov, V. (2017). Synthesis and antimicrobial properties of 4-acylaminobenzenethiosulfoacid S-esters. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 25(2), 266-274. https://doi.org/10.1016/j.jsps.2016.06.007
dc.relation.referencesen17. Derzhavna Farmakopeya Ukrayiny : v 3 t. (2-he vydannya), Derzhavne pidpryyemstvo "Ukrayinsʹkyy naukovyy farmakopeynyy tsentr yakosti likarsʹkykh zasobiv", 2-he vydannya, Kharkiv, (2015), t.3, 730;
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dc.relation.referencesen20. Reyestr veterynarnykh preparativ, kormovykh dobavok, premiksiv ta hotovykh kormiv. https://dpssukrainemy.sharepoint.com/:x:/g/personal/y_pyshenko_dpss_gov_ua/EVouDjqogJ1NqoC3KtmgiO0B6Lz5GzTmEZ7820BWTl3GVg?rtime=V0WVCwte3Eg.
dc.relation.referencesen21. Rybachuk, V. D., Ruban, O., & Filimonova, N. (2019). Microbiological justification for the choice of antimicrobic substances concentration in powder composition based on natural zeolite (clinoptyololite). Ukraïns'kij Bìofarmacevtičnij Žurnal, 0(1(58)), 4-9. https://doi.org/10.24959/ubphj.19.196
dc.relation.referencesen22. Kryshchyshyn, A. P., Kaminskyy, D. V., & Lesyk, R. B. (2015). Creation of innovative drugs (approaches and methodology of drug design) - one of the main issues of the modern pharmaceutical education. Journal of Organic and Pharmaceutical Chemistry, 13(1(49)), 49-58. https://doi.org/10.24959/ophcj.15.833
dc.relation.referencesen23. Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2012). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews, 64, 4-17. https://doi.org/10.1016/j.addr.2012.09.019
dc.relation.referencesen24. Veber, D. F., Johnson, S. R., Cheng, H. Y., Smith, B. R., Ward, K. W., & Kopple, K. D. (2002). Molecular Properties That Influence the Oral Bioavailability of Drug Candidates. Journal of Medicinal Chemistry, 45(12), 2615-2623. https://doi.org/10.1021/jm020017n
dc.relation.referencesen25. Hughes, J. D., Blagg, J., Price, D. A., Bailey, S., DeCrescenzo, G. A., Devraj, R. V., Ellsworth, E., Fobian, Y. M., Gibbs, M. E., Gilles, R. W., Greene, N., Huang, E., Krieger-Burke, T., Loesel, J., Wager, T., Whiteley, L., & Zhang, Y. (2008). Physiochemical drug properties associated with in vivo toxicological outcomes. Bioorganic & Medicinal Chemistry Letters, 18(17), 4872-4875. https://doi.org/10.1016/j.bmcl.2008.07.071
dc.relation.referencesen26. Kopak, N. A. (2023). Searching of biological activity of s-esters 4- acetylaminobenzenethiosulfoacid using methods of chemoinformatics. Chemistry, Technology and Application of Substances, 6(2), 76-86. https://doi.org/10.23939/ctas2023.02.076.
dc.relation.referencesen27. Molinspiration Cheminformatics (1986). Molinspiration Cheminformatics Software. https://www.molinspiration.com.
dc.relation.referencesen28. Sposib oderzhannya tiosulʹfonatnoyi substantsiyi. No 153357/ zayavn. Natsionalʹnyy universytet "Lʹvivsʹka politekhnika".-u202204890; zayavl. 20.12.2022; opubl. 21.06.2023; byul. No 25. Lubenetsʹ V. I., Fizer L. V., Zvarych V.I., Monʹka N.YA.
dc.relation.referencesen29. Escribano, P., & Guinea, J. (2022). Fluconazole-resistant Candida parapsilosis: A new emerging threat in the fungi arena. Frontiers in fungal biology, 3, 1010782. https://doi.org/10.3389/ffunb.2022.1010782.
dc.relation.urihttps://doi.org/10.1128/JCM.01588-17
dc.relation.urihttps://doi.org/10.1016/S1473-3099(17)30316-X
dc.relation.urihttps://doi.org/10.1146/annurev-micro-030117-020345
dc.relation.urihttps://doi.org/10.1042/EBC20160063
dc.relation.urihttps://doi.org/10.3390/ijms24065777
dc.relation.urihttps://doi.org/10.1016/S1473-3099(14)70709-1
dc.relation.urihttps://doi.org/10.2147/IDR.S173867
dc.relation.urihttps://doi.org/10.1016/j.mib.2019.10.008
dc.relation.urihttps://doi.org/10.3390/ijms24108659
dc.relation.urihttps://doi.org/10.5772/intechopen.84436
dc.relation.urihttps://doi.org/10.3390/molecules27206900
dc.relation.urihttps://doi.org/10.23939/chcht17.02.315
dc.relation.urihttps://doi.org/10.3390/nu15061363;
dc.relation.urihttps://doi.org/10.3390/vetsci10070411;
dc.relation.urihttps://doi.org/10.1016/j.jsps.2016.06.007
dc.relation.urihttp://www.drlz.com.ua;
dc.relation.urihttps://doi.org/10.24959/nphj.20.3
dc.relation.urihttps://dpssukrainemy.sharepoint.com/:x:/g/personal/y_pyshenko_dpss_gov_ua/EVouDjqogJ1NqoC3KtmgiO0B6Lz5GzTmEZ7820BWTl3GVg?rtime=V0WVCwte3Eg
dc.relation.urihttps://doi.org/10.24959/ubphj.19.196
dc.relation.urihttps://doi.org/10.24959/ophcj.15.833
dc.relation.urihttps://doi.org/10.1016/j.addr.2012.09.019
dc.relation.urihttps://doi.org/10.1021/jm020017n
dc.relation.urihttps://doi.org/10.1016/j.bmcl.2008.07.071
dc.relation.urihttps://doi.org/10.23939/ctas2023.02.076
dc.relation.urihttps://www.molinspiration.com
dc.relation.urihttps://doi.org/10.3389/ffunb.2022.1010782
dc.rights.holder© Національний університет “Львівська політехніка”, 2024
dc.subjectтіосульфонати
dc.subjectрозроблення складу
dc.subjectприсипка
dc.subjectрани
dc.subjectантимікробна дія
dc.subjectмікробіологічні дослідження
dc.subjectthiosulfonates
dc.subjectdevelopment of the composition
dc.subjectpowder
dc.subjectwounds
dc.subjectantimicrobial action
dc.subjectmicrobiological studies
dc.titleРозробка складу присипки з тіосульфонатною складовою (ААТС) та вивчення її протимікробної дії
dc.title.alternativeDevelopment of the powder composition with thiosulfonate component and study of its antimicrobial effect
dc.typeArticle

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Chemistry, Technology and Application of Substances. – 2024. – Vol. 7, No. 1