The technology basis of diclofenac substance production

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dc.citation.epage82
dc.citation.issue1
dc.citation.journalTitleХімія, технологія речовин та їх застосування
dc.citation.spage75
dc.citation.volume6
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.authorСтасевич, М. В.
dc.contributor.authorБучкевич, І. Р.
dc.contributor.authorДронік, М. Ю.
dc.contributor.authorStasevych, M. V.
dc.contributor.authorBuchkevych, I. R.
dc.contributor.authorDronik, M. Yu.
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2024-02-09T09:24:38Z
dc.date.available2024-02-09T09:24:38Z
dc.date.created2023-02-28
dc.date.issued2023-02-28
dc.description.abstractОбґрунтовано та запропоновано основи технології виробництва субстанції диклофенаку, яке складається з п’яти основних технологічних стадій. Запропоновані технологічні аспекти виробництва субстанції диклофенаку дозволяють отримати цільовий продукт із сумарним виходом 61 %. Проведено матеріальні розрахунки для одержання 1 т готової субстанції диклофенаку. Здійснено вибір кількості необхідного технологічного обладнання та запропоновано принципову технологічно схему виробництва диклофенаку.
dc.description.abstractThe basis of the production technology of the diclofenac substance, which consists of five main technological stages, is justified and proposed. The proposed technological aspects of diclofenac substance production allow obtaining the target product with a total yield of 61 %. Material calculations were carried out to obtain 1 ton of the final diclofenac substance. The numbers of necessary technological equipment are selected, and a basic technological scheme for the production of diclofenac is proposed.
dc.format.extent75-82
dc.format.pages8
dc.identifier.citationStasevych M. V. The technology basis of diclofenac substance production / M. V. Stasevych, I. R. Buchkevych, M. Yu. Dronik // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 6. — No 1. — P. 75–82.
dc.identifier.citationenStasevych M. V. The technology basis of diclofenac substance production / M. V. Stasevych, I. R. Buchkevych, M. Yu. Dronik // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 6. — No 1. — P. 75–82.
dc.identifier.doidoi.org/10.23939/ctas2023.01.075
dc.identifier.issn2617-7307
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/61174
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofХімія, технологія речовин та їх застосування, 1 (6), 2023
dc.relation.ispartofChemistry, Technology and Application of Substances, 1 (6), 2023
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dc.relation.references8. Hafeez, F., Zahoor, A. F., Ahmad, S., Ahmad, M., & amp; Faiz, S. (2018). Recent progress in the synthesis of diclofenac based NSAIDs analogs/derivatives. Synthetic Communications, 49(3), 325–350. https://doi.org/10.1080/00397911.2018.1515367.
dc.relation.references9. Zhenyu, W., Yongxi, H. U., Lin, G. U. O., Yingjie, R. E. N., Kunpeng, W. A. N. G., Quan, D. I. N. G. (2019, August 23). CN110156619A Preparation method of diclofenac. https://worldwide.espacenet.com/patent/search/family/067625640/publication/CN110156619A?q=CN110156619A.
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dc.relation.references11. Vardanyan, R. S., Hruby, V. J. (2006). Synthesis of essential drugs. Elsevier. https://doi.org/10.1016/B978-044452166-8/50036-4.
dc.relation.references12. Mei, T.-S., Wang, D.-H., Yu, J.-Q. (2010). Expedient drug synthesis and diversification via ortho-C-H iodination using recyclable PDI2 as the precatalyst. Organic Letters,12(14), 3140–3143. https://doi.org/10.1021/ol1010483.
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dc.relation.references15. U.S. National Library of Medicine. (n.d.). Diclofenac. National Center for Biotechnology Information. PubChem Compound Database. Retrieved April 4, 2023. https://pubchem.ncbi.nlm.nih.gov/compound/Diclofenac#section=Chemical-and-Physical-Properties.
dc.relation.references16. Sydorov, YU. I., Chuyeshov, V. I., Novikov, V. P. (2009). Protsesy i aparaty khimiko-farmatsevtychnoyi promyslovosti. Vinnytsya: Nova Knyha.
dc.relation.references17. Stasevych, M. V., Mylyanych, A. O., Strelnykov, L. S., Krutskykh, T. V., Buchkevych, I. R., Zaytsev, O. I., Huzova, I. O., Strilets, O. P., Hladukh, YE. V., Novikov, V. P. (2018). Tekhnolohichne obladnannya biotekhnolohichnoyi i farmatsevtychnoyi promyslovosti. Lviv: Novyy Svit-2000.
dc.relation.references18. Mylyanych, A. O. (2021). Metodychni vkazivky do praktychnykh robit z kursu Ustatkuvannya ta proektuvannya farmatsevtychnykh vyrobnytstv dlya studentiv pershoho (bakalavrskoho) rivnya vyshchoyi osvity spetsialnosti 226 Farmatsiya, promyslova farmatsiya. Lviv: Vydavnytstvo NU ―Lvivska politekhnika.
dc.relation.referencesen1. Skoutakis, V. A., Carter, C. A., Mickle, T. R., Smith, V. H., Arkin, C. R., Alissandratos, J., Petty, D. E. (1988). Review of Diclofenac and evaluation of its place in therapy as a nonsteroidal antiinflammatory agent. Drug Intelligence Clinical Pharmacy, 22(11), 850–859. https://doi.org/10.1177/106002808802201102.
dc.relation.referencesen2. Almansa, C., Alfón, J., de Arriba, A. F., Cavalcanti, F. L., Escamilla, I., Gómez, L. A., Miralles, A., Soliva, R., Bartrolí, J., Carceller, E., Merlos, M., García- Rafanell, J. (2003). Synthesis and structure − activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles. Journal of Medicinal Chemistry, 46(16), 3463–3475. https://doi.org/10.1021/jm030765s.
dc.relation.referencesen3. Palkar, M. B., Singhai, A. S., Ronad, P. M., Vishwanathswamy, A. H. M., Boreddy, T. S., Veerapur, V. P., Shaikh, M. S., Rane, R. A., Karpoormath, R. (2014). Synthesis, pharmacological screening and in silico studies of new class of diclofenac analogues as a promising anti-inflammatory agents. Bioorganic & Medicinal Chemistry, 22(10), 2855–2866. https://doi.org/10.1016/j.bmc.2014.03.043.
dc.relation.referencesen4. Dronik, M., Stasevych, M. (2022). Analysis of the pharmaceutical market of diclofenac preparations. Scientific Foundations in Medicine and Pharmacy, 104–123. https://doi.org/10.46299/isg.2022.mono.med.2.4.1.
dc.relation.referencesen5. Altman, R., Bosch, B., Brune, K., Patrignani, P., Young, C. (2015). Advances in NSAID development: Evolution of Diclofenac products using pharmaceutical technology. Drugs, 75(8), 859–877. https://doi.org/10.1007/s40265-015-0392-z.
dc.relation.referencesen6. Diclofenac uses, dosage & amp; side effects. Drugs. com. (n.d.). Retrieved February 13, 2023. https://www.drugs.com/diclofenac.html.
dc.relation.referencesen7. Alsaif, N. A., Bhat, M. A., Al-Omar, M. A., Al-Tuwajiri, H. M., Naglah, A. M., Al-Dhfyan, A. (2020). Synthesis of novel diclofenac hydrazones: Molecular docking, anti-inflammatory, analgesic, and ulcerogenic activity. Journal of Chemistry, 1–12. https://doi.org/10.1155/2020/4916726.
dc.relation.referencesen8. Hafeez, F., Zahoor, A. F., Ahmad, S., Ahmad, M., & amp; Faiz, S. (2018). Recent progress in the synthesis of diclofenac based NSAIDs analogs/derivatives. Synthetic Communications, 49(3), 325–350. https://doi.org/10.1080/00397911.2018.1515367.
dc.relation.referencesen9. Zhenyu, W., Yongxi, H. U., Lin, G. U. O., Yingjie, R. E. N., Kunpeng, W. A. N. G., Quan, D. I. N. G. (2019, August 23). CN110156619A Preparation method of diclofenac. https://worldwide.espacenet.com/patent/search/family/067625640/publication/CN110156619A?q=CN110156619A.
dc.relation.referencesen10. Kun, Z., Yanjie, L. (2018). Research progress of synthesis of diclofenac sodium. Topics in Chemical Material Engineering. https://doi.org/10.26480/icnmim.01.2018.276.279.
dc.relation.referencesen11. Vardanyan, R. S., Hruby, V. J. (2006). Synthesis of essential drugs. Elsevier. https://doi.org/10.1016/B978-044452166-8/50036-4.
dc.relation.referencesen12. Mei, T.-S., Wang, D.-H., Yu, J.-Q. (2010). Expedient drug synthesis and diversification via ortho-C-H iodination using recyclable PDI2 as the precatalyst. Organic Letters,12(14), 3140–3143. https://doi.org/10.1021/ol1010483.
dc.relation.referencesen13. CAS SciFinderⁿ – Chemical Compound Database. CAS. (n.d.). Retrieved February 13, 2023. https://www.cas.org/solutions/cas-scifinder-discovery-platform/cas-scifinder
dc.relation.referencesen14. Diclofenac. ChemSpider. (n.d.). Retrieved April 4, 2023. http://www.chemspider.com/Chemical-Structure.2925.html.
dc.relation.referencesen15. U.S. National Library of Medicine. (n.d.). Diclofenac. National Center for Biotechnology Information. PubChem Compound Database. Retrieved April 4, 2023. https://pubchem.ncbi.nlm.nih.gov/compound/Diclofenac#section=Chemical-and-Physical-Properties.
dc.relation.referencesen16. Sydorov, YU. I., Chuyeshov, V. I., Novikov, V. P. (2009). Protsesy i aparaty khimiko-farmatsevtychnoyi promyslovosti. Vinnytsya: Nova Knyha.
dc.relation.referencesen17. Stasevych, M. V., Mylyanych, A. O., Strelnykov, L. S., Krutskykh, T. V., Buchkevych, I. R., Zaytsev, O. I., Huzova, I. O., Strilets, O. P., Hladukh, YE. V., Novikov, V. P. (2018). Tekhnolohichne obladnannya biotekhnolohichnoyi i farmatsevtychnoyi promyslovosti. Lviv: Novyy Svit-2000.
dc.relation.referencesen18. Mylyanych, A. O. (2021). Metodychni vkazivky do praktychnykh robit z kursu Ustatkuvannya ta proektuvannya farmatsevtychnykh vyrobnytstv dlya studentiv pershoho (bakalavrskoho) rivnya vyshchoyi osvity spetsialnosti 226 Farmatsiya, promyslova farmatsiya. Lviv: Vydavnytstvo NU ―Lvivska politekhnika.
dc.relation.urihttps://doi.org/10.1177/106002808802201102
dc.relation.urihttps://doi.org/10.1021/jm030765s
dc.relation.urihttps://doi.org/10.1016/j.bmc.2014.03.043
dc.relation.urihttps://doi.org/10.46299/isg.2022.mono.med.2.4.1
dc.relation.urihttps://doi.org/10.1007/s40265-015-0392-z
dc.relation.urihttps://www.drugs.com/diclofenac.html
dc.relation.urihttps://doi.org/10.1155/2020/4916726
dc.relation.urihttps://doi.org/10.1080/00397911.2018.1515367
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/067625640/publication/CN110156619A?q=CN110156619A
dc.relation.urihttps://doi.org/10.26480/icnmim.01.2018.276.279
dc.relation.urihttps://doi.org/10.1016/B978-044452166-8/50036-4
dc.relation.urihttps://doi.org/10.1021/ol1010483
dc.relation.urihttps://www.cas.org/solutions/cas-scifinder-discovery-platform/cas-scifinder
dc.relation.urihttp://www.chemspider.com/Chemical-Structure.2925.html
dc.relation.urihttps://pubchem.ncbi.nlm.nih.gov/compound/Diclofenac#section=Chemical-and-Physical-Properties
dc.rights.holder© Національний університет “Львівська політехніка”, 2023
dc.subject2
dc.subject6-дихлоранілін
dc.subjectкалію 2-(2-йодфеніл)ацетат
dc.subjectміді йодид
dc.subjectдиклофенак
dc.subjectоснови технології
dc.subjectматеріальні розрахунки
dc.subjectтехнологічні розрахунки
dc.subjectтеплові розрахунки
dc.subjectпринципова технологічна схема
dc.subject2
dc.subject6-dichloroaniline
dc.subjectpotassium 2-(2-iodophenyl)acetate
dc.subjectcopper iodide
dc.subjectdiclofenac
dc.subjectbasics of technology
dc.subjectmaterial calculations
dc.subjecttechnological calculations
dc.subjectthermal calculations
dc.subjectbasic technological scheme
dc.titleThe technology basis of diclofenac substance production
dc.title.alternativeОснови технології одержання субстанції диклофенаку
dc.typeArticle

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Chemistry, Technology and Application of Substances. – 2023. – Vol. 6, No. 1