Антиоксидантний вплив гумінових кислот на гепатоцити щура

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dc.citation.epage71
dc.citation.issue2
dc.citation.spage64
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationІнститут фізико–органічної хімії та вуглехімії ім. Л. М. Литвиненка Національної академії наук України
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.affiliationLytvynenko Institute of Physicoorganic and Coal Chemistry Ukrainian
dc.contributor.authorІванишин, О. Я.
dc.contributor.authorЯремкевич, О. С.
dc.contributor.authorСеменюк, І. В.
dc.contributor.authorКарпенко, О. В.
dc.contributor.authorМонька, Н. Я.
dc.contributor.authorЛубенець, В. І.
dc.contributor.authorIvanushun, O. Ya.
dc.contributor.authorIaremkevych, O. S.
dc.contributor.authorSemeniuk, I. V.
dc.contributor.authorKarpenko, O. V.
dc.contributor.authorMonka, N. Ya.
dc.contributor.authorLubenets, V. I.
dc.coverage.placenameLviv
dc.coverage.placenameLviv
dc.date.accessioned2024-01-22T08:47:06Z
dc.date.available2024-01-22T08:47:06Z
dc.date.created2020-03-16
dc.date.issued2020-03-16
dc.description.abstractОтримано гумінові кислоти з різних природних джерел (з біогумусу, з чорнозему Тернопільської області, з торфів районів Великого Любіня, Дрогобича та Республіки Білорусь). Методами титриметричного аналізу визначено кількісний склад функціональних груп отриманих гумінових кислот, які мають кислі властивості. За даними термогравіметричного аналізу розраховано значення коефіцієнтів, що показують співвідношення їх аліфатичної частини до циклічної. Встановлено, що всі отримані гумінові кислоти виявляють антиоксидантні властивості: спостерігається зниження вмісту тіобарбітурат-активних продуктів і карбонільних груп протеїнів у гепатоцитах печінки щура. Утворення продуктів вільнорадикального пошкодження ліпідних компонентів та протеїнів найкраще інгібували 1%-ві розчини гуматів з біогумусу та гумінових кислот з торфу. Це свідчить про їхні перспективи для розроблення засобів відновлення фізіологічних функцій біологічних об’єктів за патологічних станів в умовах вільно-радикального стресу.
dc.description.abstractThe antioxidant properties of humic acids of various origins have been investigated (from bio-humus, black soil from Ternopil region, and peat from different regions, such as: Velykyi Liubin, Drohobych and Belarus Republic). Titrimetric analysis has been shown the quantitative composition of the acidic functional groups of the obtained humic acids. According to the data of thermogravimetric analysis, the values of parameters, showing the ratio of their aliphatic to the cyclic part were determined. It was found that all obtained humic acids are characterized by high antioxidant activity: the formation of thiobarbituractive products and carbonyl groups of proteins in liver hepatocytes were decreased. The inhibition of the products of free radical formation of lipid components and proteins was better inhibited by 1 % solutions of humates from vermicompost and humic acids from peat. The results indicate prospects of the humic acids for creating the means of restoring the physiological functions of biological objects in pathological conditions under conditions of free radical stress for application in cosmetic pharmaceutical products.
dc.format.extent64-71
dc.format.pages8
dc.identifier.citationАнтиоксидантний вплив гумінових кислот на гепатоцити щура / О. Я. Іванишин, О. С. Яремкевич, І. В. Семенюк, О. В. Карпенко, Н. Я. Монька, В. І. Лубенець // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2021. — Том 4. — № 2. — С. 64–71.
dc.identifier.citationenAntioxidant effect of humic acids on rat hepatocytes / O. Ya. Ivanushun, O. S. Iaremkevych, I. V. Semeniuk, O. V. Karpenko, N. Ya. Monka, V. I. Lubenets // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2021. — Vol 4. — No 2. — P. 64–71.
dc.identifier.doidoi.org/10.23939/ctas2021.02.064
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/60880
dc.language.isouk
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry, Technology and Application of Substances, 2 (4), 2021
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dc.relation.referencesen1. Yashchuk V. U., Koretskyi A. P., Kovbasenko R. V., Dmytriiev O. P., Kovbasenko V. M. (2016). Humic substances. Safe ecosystem regulators, 4. [in Ukraine].
dc.relation.referencesen2. https://uk.wikipedia.org/wiki/
dc.relation.referencesen3. Saranchuk V. I., Iliashov M. O., Oshovskyi V. V., Biletskyi V. S. (2008). Chemistry and physics of combustible minerals. Donetsk, Eastern Publishing House. [in Ukraine].
dc.relation.referencesen4. Horovaia A. Y., Orlov D. S., Shcherbenko O. V. (1995). Humic substances. Structure, functions, mechanism of action, protector properties, ecological role. Kiev, Scientific thought. [in Ukraine].
dc.relation.referencesen5. Mykhailenko Ye. O., Domshyna O. O., Ushakova H. O., Hryban V. H., Stepchenko L. M. (2016). The effect of feed additive "Humilid" on the indicators of protein and amino acid metabolism in broiler chickens cross Cobb 500. Animal biology, 4, 66–71. [in Ukraine].
dc.relation.referencesen6. Buchko O. M., Salyha N. O., Svarchevska O. Z., Maksymovych I. Ia., Senkiv O. M. (2013). Immunological and hematological parameters of the blood of piglets under the action of humic additives. Bulletin of ONU, ser., Biology, 18, 3(32), 73–81. [in Ukraine].
dc.relation.referencesen7. Buzlama A. V., Chernov Yu. N. (2010). Analysis of pharmacological properties, mechanisms of action and prospects for the use of humic substances in medicine. Experimental and clinical pharmacology, 73(9), 43–48. [in Ukraine].
dc.relation.referencesen8. Lobodyn K. A., Nezhdanov A. H., Buzlama V. S. (2006). Ligfol to correct the reproductive function of cows. Veterinary medicine, 3, 39–44. [in Ukraine].
dc.relation.referencesen9. Hryban V. H. (1995). To the mechanism of action of drugs of humic nature on the body of animals. Organic matter of peat, Minsk, 120 p. [in Ukraine].
dc.relation.referencesen10. Ysmatova R. R., Zyhanshyn A. U., Dmytruk S. E. (2007). Experimental study of sodium humate from peat for allergodermatosis application. Modern high technologies, 3, 28–30. [in Ukraine].
dc.relation.referencesen11. Coates J., Cole K., Chakraborty R. (2002). Diversity and ubiquity of bacteria capable of utilization humic substances as electron donors for anaerobic respiration. Applied and environmental microbiology, 5, 2445–2452.
dc.relation.referencesen12. Ermahambet B. T., Kukhar E. V., Nurhalyev N. U., Kasenova Zh. M., Zykyryna A. M. (2016). Effective use of humic preparations (based on humates) in animal husbandry and veterinary medicine. Achievements of science and 149 education, 10(11), 16–19. [in Ukraine].
dc.relation.referencesen13. Knight J. A. (2000). Review: Free radicals, antioxidants, and the immune system. Ann. Clin. Lab. Sci., 30(2), 145–158.
dc.relation.referencesen14. Sanmiguel P., Rondon B. Iang. (2016). Supplementation with humic substances affects the innate immunity. Rev. MVZ Cordoba, 21(1), 5198–5210.
dc.relation.referencesen15. Buron N., Porceddu M., Roussel C., Begriche K., Trak-Smayra V., Gicquel T., Fromenty B., Borgne-Sanchez A. (2017). Chronic and low exposure to a pharmaceutical cocktail induces mitochondrial dysfunction in liver and hyperglycemia: Differential responses between lean and obese mice. Environmental Toxicology, 32, 1375–1389. doi:https://doi.org/10.1002/tox.22331.
dc.relation.referencesen16. Mykhailenko Ye. O., Domshyna O. O., Ushakova H. O., Stepchenko L. M. (2016). Efficiency of the antioxidant system of the broiler liver in the Cobb-500 cross with natural biological active additives based on humic fluids. Bulletin of the State Agrarian and Economic University, 4(42), 120–125. [in Ukraine].
dc.relation.referencesen17. Shostia A. M., Pavlova I. V., Chukhlib Ye. V., Kuzmenko L. M., Kodak T. S., Bereznytskyi V. I., Shaferivskyi B. S. (2020). Infusion of humates on prooxidantantioxidant homeostasis in knuriv-plidnikiv under heat stress. Bulletin of the Poltava State Agrarian Academy, 1, 114−120. [in Ukraine].
dc.relation.referencesen18. Lushchak V. I., Bagnyukova T. V., Luzhna L. I. (2006). Indices of oxidative stress. 2. Lipid peroxides. The Ukrainian Biochemical Journal, 78(5), 113–119. [in Ukraine].
dc.relation.referencesen19. Bravo L. (1998). Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance. Nutrition Reviews 56(11), 317–333.
dc.relation.referencesen20. Stepchenko L. M. (2010). System of antioxidant protection of the body of piglets under the action of additives of humic nature Regulatory mechanisms of action of biologically active substances of humic nature on the body of productive birds. Physiological Journal, 56(2), 306 c. [in Ukraine].
dc.relation.referencesen21. Buchko O. M. (2012). The system of antioxidant protection of the body of piglets under the action of additives of humic nature. Bulletin of Lviv University, series: Biology, 58, 68–73. [in Ukraine].
dc.relation.urihttps://uk.wikipedia.org/wiki/
dc.relation.urihttps://doi.org/10.1002/tox.22331
dc.rights.holder© Національний університет “Львівська політехніка”, 2021
dc.subjectгумінові кислоти
dc.subjectантиоксидантні властивості
dc.subjectтіобарбітуратактивні продукти
dc.subjectокисна модифікація білка
dc.subjecthumic acids
dc.subjectantioxidant properties
dc.subjectthiobarbituric products
dc.subjectoxidative modification of proteins
dc.titleАнтиоксидантний вплив гумінових кислот на гепатоцити щура
dc.title.alternativeAntioxidant effect of humic acids on rat hepatocytes
dc.typeArticle

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Chemistry, Technology and Application of Substances. – 2021. – Vol. 4, No. 2