Вплив похідних тіосульфокислот на морфологічні властивості зародків в’юна на початкових стадіях розвитку

dc.citation.epage109
dc.citation.issue1
dc.citation.journalTitleХімія, технологія речовин та їх застосування
dc.citation.spage99
dc.citation.volume6
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.authorЯремкевич, О. С.
dc.contributor.authorЛубенець, В. І.
dc.contributor.authorYaremkevych, O. S.
dc.contributor.authorLubenets, V. I.
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2024-02-09T09:24:41Z
dc.date.available2024-02-09T09:24:41Z
dc.date.created2023-02-28
dc.date.issued2023-02-28
dc.description.abstractМорфологічними дослідженнями встановлено, що за дії тіосульфонатів різної будови не спостерігається інгібування поділів бластомерів та формування зародкових шарів у в’юна (MisgurnusfossilisL). Проте за дії нітробензентіосульфонату калію (НТК) спостерігається затримка в розвитку зародків в’юна приблизно на 13–16 год із подальшою судинною патологією. За дії НТК у зародків в’юна спостерігаються виражені зміни серцево-судинної системи, які проявлялися розширенням кровоносних судин. Отримані результати на тест-модельних об’єктах свідчать про перспективи похідних тіосульфокислот, зокрема НТК, як нових антитромботичних та антиагрегантних засобів із високою ефективністю і низькою токсичністю.
dc.description.abstractBy means of morphological studies, it was established that the influence of thiosulfonate solutions of different structure doesn’t show an inhibition of blastomere division and germ layer formation of the freshwater bony fish, namely weatherfish (MisgurnusfossilisL). However, under the effect of potassium nitrobenzenethiosulfonate (NTK), at the pre-hatching stage (36thdevelopment stage), that is responsible for the establishment of erythrocyte circulation, external gills predevelopment and the appearance of pigmentation, we observed a delay for approximately 13–16 hours with the imminent vascular pathology. The pronounced changes of cardio-vascular system, which manifested itself in vasodilation, were spotted later on after the NTK influence.The results showed evidence of thiosulfate acid’s derivatives, namely NTK, being promising, highly efficient, non-toxic antithrombotic and antiplatelet remedies.
dc.format.extent99-109
dc.format.pages11
dc.identifier.citationЯремкевич О. С. Вплив похідних тіосульфокислот на морфологічні властивості зародків в’юна на початкових стадіях розвитку / О. С. Яремкевич, В. І. Лубенець // Хімія, технологія речовин та їх застосування. — Львів : Видавництво Львівської політехніки, 2023. — Том 6. — № 1. — С. 99–109.
dc.identifier.citationenYaremkevych O. S. The influence of thiosulfic acid derivatives on the morphological properties of loach embryos at the initial stages of development / O. S. Yaremkevych, V. I. Lubenets // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 6. — No 1. — P. 99–109.
dc.identifier.doidoi.org/10.23939/ctas2023.01.099
dc.identifier.issn2617-7307
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/61178
dc.language.isouk
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofХімія, технологія речовин та їх застосування, 1 (6), 2023
dc.relation.ispartofChemistry, Technology and Application of Substances, 1 (6), 2023
dc.relation.references1. Hromova, V.P., Omelianchyk, L., & Brazhko, O. (2005). Doslidzhennia antyoksydantnoi aktyvnosti tiopokhidnykh khinolinu. Ukrainskyi biokhimichnyi zhurnal, 77(3), 87-95.
dc.relation.references2. Smith, M., Hunter, R., Stellenboom, N., Kusza, D. A., Parker, M. I., Hammouda, A. N. H., Jackson, G., Kaschula, C. H. (2016). The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS. Biochimica et Biophysica Acta 1860, 1439–1449. https://doi.org/10.1016/j.bbagen.2016.03.032.
dc.relation.references3. Mampuys, P., McElroy, C. R., Clark, J. H., Orru, R. V. A., Maes, B. U. W. (2019). Thiosulfonates as Emerging Reactants: Synthesis and Applications. Adv. Synth. Catal., 362, 1–59. https://doi.org/10.1002/adsc.201900864.
dc.relation.references4. Martín-García, A. I., García-Pareja, M. P., Alcaide, E. M. (2011). Effects of garlic compounds on the in vitro ruminal fermentation promoted by diets based on alfalfa hay. Options Méditerranéennes, 99, 115–119.
dc.relation.references5. Wu, X., Santos, R. R., Fink-Gremmels, J. (2015). Analyzing the antibacterial effects of food ingredients: Model experiments with allicin and garlic extracts on biofilm formation and viability of Staphylococcus epidermidis. Food science and nutrition, 3, 158–168. DOI: 10.1002/fsn3.199.
dc.relation.references6. Loi, V. V., Huyen, N. T. T., Busche. T., Tung, Q. N., Gruhlke, M. C. H., Kalinowski. J., Bernhardt. J., Slusarenko. A. J., Antelmann, H. (2019). Staphylococcus aureus responds to allicin by global S-thioallylation-Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress. Free Radical Biology and Medicine, 139, 55-69. DOI: 10.1016/j.freeradbiomed. 2019.05.018.
dc.relation.references7. Maino, A., Siegerink, B., Algra, A., Peyvandi, F., Rosendaal, F. R. (2016). Recurrence and Mortality in Young Women With Myocardial Infarction or Ischemic Stroke. JAMA Internal Medicine, 176(1), 134–136. doi:10.1001/ jamainternmed.2015.6523.
dc.relation.references8. Babak, O. Ya., Bilovol, O. M., Yakovleva, O. O. (2010). Klinichna farmakolohiya: pidruchnyk dlya medychnykh VNZ III-IV rivniv akredytatsiyi. Kуіv: Medytsyna, 776.
dc.relation.references9. Martin, S. A., Brash, A. R., Murphy, R. C. (2016). Murphy Thematic Review Series: Living History of Lipids: The discovery and early structural studies of arachidonic acid. J. Lipid Res., 57(7), 1126–1132.
dc.relation.references10. Pettersen, A. A., Arnesen, H., Seljeflot, I. (2015). A brief review on high on-aspirin residual platelet reactivity. Vascul Pharmacol., 67(69), 6–9. doi: 10.1016/j.vph. 2015.03.018. https://doi.org/10.1016/j.vph.2015.03.018.
dc.relation.references11. Rahman, K. (2007). Effects of garliconplatelet biochemistry and physiology. Mol. Nutr Food, 51(11), 1335–1344. DOI: 10.1002/mnfr.200700058.
dc.relation.references12. Fukao, H., Yoshida, H., Tazawa, Y. (2007). Antithrombotic effects of odorless garlic powder both in vitro and in vivo. Biosci Biotechnol Biochem., 71(1), 84–90. DOI: 10.1271/bbb.60380.
dc.relation.references13. Zhang, H. X., Shi, Z. X., Jia, H. Z. (2007). Effects of garlicin on NIH3T3 cell proliferation and collagen synthesis. Zhongguo Zhong Xi Yi Jie He Za Zhi., 27(5), 431–434.
dc.relation.references14. Romano, E. L., Montaño, R. F., Brito, B., Apitz, R., Alonso, J., Romano, M., Gebrán, S., Soyano, A. (1997). Effects of Ajoene on lymphocyte and macrophage membrane- dependent functions. Immunopharmacol. Immunotoxicol., 19(1), 15–36. DOI: 10.3109/08923979709038531.
dc.relation.references15. Prasad, V. N. V. (2000).Synthesis of Heterocyclic Thiosulfonates. J. Org. Lett. 2(8), 1069–1072. https://doi.org/10.1021/ol0056170
dc.relation.references16. Allison , G. L., Lowe, G. M., Rahman, K. (2012). Aged garlic extract inhibits platelet activation by increasing intracellular cAMP and reducing the interaction of GPIIb/IIIa receptor with fibrinogen. National Library of Medicine, 91(25-26), 127–580. DOI: 10.1016/j.lfs.2012.09.019.
dc.relation.references17. Kryzhanovskiy, S. G. (1949). Ekologomorfologicheskiye zakonomernosti razvitiya karpovykh, vyunovykh i somovykh ryb (Cyprinoidei i Suluroidei). Trudy In-ta morf. zhivotnykh. AN SSSR, 1, 186–195.
dc.relation.references18. Drozd, B., Kouril, J., Blaha, M., Hamackova, J. (2009). Effect of temperature on early life history in weatherfish, Misgurnus fossilis (L. 1758). Knowledge and Management of Aquatic Ecosystems,392, 4. http://www.kmae-journal.org doi: 10.1051/kmae/2009010.
dc.relation.references19. Bodnarchuk, N., Kulachkovsky, O., Mandzynets, S., Sanagurskiy, D. (2016). Structural changes of loach embryos during embryogenesis under the influence of Flurenizyd. Annales umcs, 34(4), 16–30.
dc.relation.references20. Tselevych, M. V. (2008). Osoblyvosti ultrastruktury embrioniv vyuna pid vplyvom norfloksatsynu. Tsytol. Zhene., 42, 96–100. https://doi.org/10.1007/s11956-008-2005-1.
dc.relation.references21. Kopeika, J. (2021). Effect of Cryopreservation on the Genome of Sperm in Animals and Humans. Springer Nature Switzerland AG, 151–173. https://doi.org/10.1007/978-3-030-66292-9_22.
dc.relation.references22. Neyfakh, A. A. (1977). Molekulyarnaya byolohyya protsessov razvytyya. Mоsva: Nauka, 311.
dc.relation.references23. Sanahurkyy, D. I. ( 2008). Obyekty biofizyky. Monohrafiya. Lviv: Vydavnychyy tsentr LNU im. Iv. Franka, 522.
dc.relation.references24. Detlaf, T. A., Detlaf, A. A. (1960). O bezrazmernykh kharakterystykakh prodolzhytelnosty razvytyya v émbryolohyy. Dokl. AN SSSR, 134(1), 199–202.
dc.relation.references25. Kostomarova, A. A. (1975). Vyun Misgurnus fossilis. Obekty byolohyy razvytyya. Mоsva: Nauka, 308–323.
dc.relation.references26. 26. Lubenets, V. I. (2003). Tiosulfonaty: syntez i vlastyvosti. Ukr. khim. zhurn., 69(8), 114–121.
dc.relation.references27. Morgan, G. A., Leech, N. L., Gloeckner, G. W., Barrett, K. C. (2012). IBM SPSS for Introductory Statistics. In: Use and Interpretation. Fourth Edition. Routledge Taylor & amp. Francis Group. New-York, 256.
dc.relation.referencesen1. Hromova, V.P., Omelianchyk, L., & Brazhko, O. (2005). Doslidzhennia antyoksydantnoi aktyvnosti tiopokhidnykh khinolinu. Ukrainskyi biokhimichnyi zhurnal, 77(3), 87-95.
dc.relation.referencesen2. Smith, M., Hunter, R., Stellenboom, N., Kusza, D. A., Parker, M. I., Hammouda, A. N. H., Jackson, G., Kaschula, C. H. (2016). The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS. Biochimica et Biophysica Acta 1860, 1439–1449. https://doi.org/10.1016/j.bbagen.2016.03.032.
dc.relation.referencesen3. Mampuys, P., McElroy, C. R., Clark, J. H., Orru, R. V. A., Maes, B. U. W. (2019). Thiosulfonates as Emerging Reactants: Synthesis and Applications. Adv. Synth. Catal., 362, 1–59. https://doi.org/10.1002/adsc.201900864.
dc.relation.referencesen4. Martín-García, A. I., García-Pareja, M. P., Alcaide, E. M. (2011). Effects of garlic compounds on the in vitro ruminal fermentation promoted by diets based on alfalfa hay. Options Méditerranéennes, 99, 115–119.
dc.relation.referencesen5. Wu, X., Santos, R. R., Fink-Gremmels, J. (2015). Analyzing the antibacterial effects of food ingredients: Model experiments with allicin and garlic extracts on biofilm formation and viability of Staphylococcus epidermidis. Food science and nutrition, 3, 158–168. DOI: 10.1002/fsn3.199.
dc.relation.referencesen6. Loi, V. V., Huyen, N. T. T., Busche. T., Tung, Q. N., Gruhlke, M. C. H., Kalinowski. J., Bernhardt. J., Slusarenko. A. J., Antelmann, H. (2019). Staphylococcus aureus responds to allicin by global S-thioallylation-Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress. Free Radical Biology and Medicine, 139, 55-69. DOI: 10.1016/j.freeradbiomed. 2019.05.018.
dc.relation.referencesen7. Maino, A., Siegerink, B., Algra, A., Peyvandi, F., Rosendaal, F. R. (2016). Recurrence and Mortality in Young Women With Myocardial Infarction or Ischemic Stroke. JAMA Internal Medicine, 176(1), 134–136. doi:10.1001/ jamainternmed.2015.6523.
dc.relation.referencesen8. Babak, O. Ya., Bilovol, O. M., Yakovleva, O. O. (2010). Klinichna farmakolohiya: pidruchnyk dlya medychnykh VNZ III-IV rivniv akredytatsiyi. Kuiv: Medytsyna, 776.
dc.relation.referencesen9. Martin, S. A., Brash, A. R., Murphy, R. C. (2016). Murphy Thematic Review Series: Living History of Lipids: The discovery and early structural studies of arachidonic acid. J. Lipid Res., 57(7), 1126–1132.
dc.relation.referencesen10. Pettersen, A. A., Arnesen, H., Seljeflot, I. (2015). A brief review on high on-aspirin residual platelet reactivity. Vascul Pharmacol., 67(69), 6–9. doi: 10.1016/j.vph. 2015.03.018. https://doi.org/10.1016/j.vph.2015.03.018.
dc.relation.referencesen11. Rahman, K. (2007). Effects of garliconplatelet biochemistry and physiology. Mol. Nutr Food, 51(11), 1335–1344. DOI: 10.1002/mnfr.200700058.
dc.relation.referencesen12. Fukao, H., Yoshida, H., Tazawa, Y. (2007). Antithrombotic effects of odorless garlic powder both in vitro and in vivo. Biosci Biotechnol Biochem., 71(1), 84–90. DOI: 10.1271/bbb.60380.
dc.relation.referencesen13. Zhang, H. X., Shi, Z. X., Jia, H. Z. (2007). Effects of garlicin on NIH3T3 cell proliferation and collagen synthesis. Zhongguo Zhong Xi Yi Jie He Za Zhi., 27(5), 431–434.
dc.relation.referencesen14. Romano, E. L., Montaño, R. F., Brito, B., Apitz, R., Alonso, J., Romano, M., Gebrán, S., Soyano, A. (1997). Effects of Ajoene on lymphocyte and macrophage membrane- dependent functions. Immunopharmacol. Immunotoxicol., 19(1), 15–36. DOI: 10.3109/08923979709038531.
dc.relation.referencesen15. Prasad, V. N. V. (2000).Synthesis of Heterocyclic Thiosulfonates. J. Org. Lett. 2(8), 1069–1072. https://doi.org/10.1021/ol0056170
dc.relation.referencesen16. Allison , G. L., Lowe, G. M., Rahman, K. (2012). Aged garlic extract inhibits platelet activation by increasing intracellular cAMP and reducing the interaction of GPIIb/IIIa receptor with fibrinogen. National Library of Medicine, 91(25-26), 127–580. DOI: 10.1016/j.lfs.2012.09.019.
dc.relation.referencesen17. Kryzhanovskiy, S. G. (1949). Ekologomorfologicheskiye zakonomernosti razvitiya karpovykh, vyunovykh i somovykh ryb (Cyprinoidei i Suluroidei). Trudy In-ta morf. zhivotnykh. AN SSSR, 1, 186–195.
dc.relation.referencesen18. Drozd, B., Kouril, J., Blaha, M., Hamackova, J. (2009). Effect of temperature on early life history in weatherfish, Misgurnus fossilis (L. 1758). Knowledge and Management of Aquatic Ecosystems,392, 4. http://www.kmae-journal.org doi: 10.1051/kmae/2009010.
dc.relation.referencesen19. Bodnarchuk, N., Kulachkovsky, O., Mandzynets, S., Sanagurskiy, D. (2016). Structural changes of loach embryos during embryogenesis under the influence of Flurenizyd. Annales umcs, 34(4), 16–30.
dc.relation.referencesen20. Tselevych, M. V. (2008). Osoblyvosti ultrastruktury embrioniv vyuna pid vplyvom norfloksatsynu. Tsytol. Zhene., 42, 96–100. https://doi.org/10.1007/s11956-008-2005-1.
dc.relation.referencesen21. Kopeika, J. (2021). Effect of Cryopreservation on the Genome of Sperm in Animals and Humans. Springer Nature Switzerland AG, 151–173. https://doi.org/10.1007/978-3-030-66292-9_22.
dc.relation.referencesen22. Neyfakh, A. A. (1977). Molekulyarnaya byolohyya protsessov razvytyya. Mosva: Nauka, 311.
dc.relation.referencesen23. Sanahurkyy, D. I. ( 2008). Obyekty biofizyky. Monohrafiya. Lviv: Vydavnychyy tsentr LNU im. Iv. Franka, 522.
dc.relation.referencesen24. Detlaf, T. A., Detlaf, A. A. (1960). O bezrazmernykh kharakterystykakh prodolzhytelnosty razvytyya v émbryolohyy. Dokl. AN SSSR, 134(1), 199–202.
dc.relation.referencesen25. Kostomarova, A. A. (1975). Vyun Misgurnus fossilis. Obekty byolohyy razvytyya. Mosva: Nauka, 308–323.
dc.relation.referencesen26. 26. Lubenets, V. I. (2003). Tiosulfonaty: syntez i vlastyvosti. Ukr. khim. zhurn., 69(8), 114–121.
dc.relation.referencesen27. Morgan, G. A., Leech, N. L., Gloeckner, G. W., Barrett, K. C. (2012). IBM SPSS for Introductory Statistics. In: Use and Interpretation. Fourth Edition. Routledge Taylor & amp. Francis Group. New-York, 256.
dc.relation.urihttps://doi.org/10.1016/j.bbagen.2016.03.032
dc.relation.urihttps://doi.org/10.1002/adsc.201900864
dc.relation.urihttps://doi.org/10.1016/j.vph.2015.03.018
dc.relation.urihttps://doi.org/10.1021/ol0056170
dc.relation.urihttp://www.kmae-journal.org
dc.relation.urihttps://doi.org/10.1007/s11956-008-2005-1
dc.relation.urihttps://doi.org/10.1007/978-3-030-66292-9_22
dc.rights.holder© Національний університет “Львівська політехніка”, 2023
dc.subjectтіосульфонати
dc.subjectбластомери
dc.subjectзародки в’юна MisgurnusfossilisL
dc.subjectthiosulfonates
dc.subjectblastomeres
dc.subjectloach embryos of MisgurnusfossilisL
dc.titleВплив похідних тіосульфокислот на морфологічні властивості зародків в’юна на початкових стадіях розвитку
dc.title.alternativeThe influence of thiosulfic acid derivatives on the morphological properties of loach embryos at the initial stages of development
dc.typeArticle

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
2023v6n1_Yaremkevych_O_S-The_influence_of_thiosulfic_99-109.pdf
Size:
4.01 MB
Format:
Adobe Portable Document Format
Thumbnail Image
Name:
2023v6n1_Yaremkevych_O_S-The_influence_of_thiosulfic_99-109__COVER.png
Size:
461.22 KB
Format:
Portable Network Graphics

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.81 KB
Format:
Plain Text
Description: