Preparation of nanostructural dextran-based carrier particles for drug delivery to the lungs

Abstract

Particle engineering can be used to design inhalation drug carrier that will combine advantages of nano- and microparticles. This work present a review of research on dextran-based nanostructural powder prepared using the spray drying method. The shape of powder particles is shown to depend on the applied drying process parameters and additives used. It was proved that surface morphology of particles strongly affects powder aerosolization performance. Tested powders demonstrated a good restoration of the initial nanoparticles size distribution after rehydration. All these features allow to consider dextran-based nanostructural particles as new attractive carriers for drug delivery to the lungs.