Development of the basics of spray technology for external application

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dc.citation.epage101
dc.citation.issue2
dc.citation.journalTitleChemistry, Technology and Application of Substances
dc.citation.spage93
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationКаунаський технологічний університет
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.affiliationKaunas University of Technology
dc.contributor.authorДронік, М. Ю.
dc.contributor.authorЙонускене, І.
dc.contributor.authorСтасевич, М. В.
dc.contributor.authorDronik, M. Yu.
dc.contributor.authorJonuškienė, I.
dc.contributor.authorStasevych, M. V.
dc.coverage.placenameLviv
dc.coverage.placenameLviv
dc.date.accessioned2025-03-05T08:12:25Z
dc.date.created2023-02-28
dc.date.issued2023-02-28
dc.description.abstractРозроблено основи технології одержання засобу для місцевого застосування зі знеболювальною та протизапальною дією у формі спрея. Запропоновано кількісний вміст активних фармацевтичних інгредієнтів та допоміжних речовин. Виконано порівняльний аналіз деяких показників одержаного спрея з аналогами на фармацевтичному ринку України. Матеріальні розрахунки дали змогу оцінити кількості активних фармацевтичних інгредієнтів та допоміжних речовин для одержання спрея та фасування його у флакони у лабораторних умовах. На основі матеріальних розрахунків запропоновано принципову технологічну схему виробництва готового лікарського засобу. Виконано економічні розрахунки, що демонструють високий рівень економічної вигідності розроблення такого лікарського засобу.
dc.description.abstractThe basics of the technology for the preparation of a spray formulation for external use with analgesic and anti-inflammatory effects was developed. The quantitative content of active pharmaceutical ingredients and excipients was proposed. Comparative analysis of some indicators of the obtained spray with analogues on the pharmaceutical market of Ukraine was carried out. Material calculations allowed to estimate the amount of active pharmaceutical ingredients and excipients for the preparation of the spray and its packaging in bottles with a dropper in the laboratory. Based on the material calculations, a basic technological scheme for the production of the finished product was proposed. Economic calculations have been carried out, which demonstrate a high level of economic profitability of the development of such a preparation.
dc.format.extent93-101
dc.format.pages9
dc.identifier.citationDronik M. Yu. Development of the basics of spray technology for external application / M. Yu. Dronik, I. Jonuškienė, M. V. Stasevych // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 6. — No 2. — P. 93–101.
dc.identifier.citationenDronik M. Yu. Development of the basics of spray technology for external application / M. Yu. Dronik, I. Jonuškienė, M. V. Stasevych // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 6. — No 2. — P. 93–101.
dc.identifier.doidoi.org/10.23939/ctas2023.02.093
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/63670
dc.language.isoen
dc.publisherLviv Politechnic Publishing House
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry, Technology and Application of Substances, 2 (6), 2023
dc.relation.ispartofChemistry, Technology and Application of Substances, 2 (6), 2023
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dc.relation.referencesen4. Sobeeh, M. G., Hassan, K. A., da Silva, A. G., Youssef, E. F., Fayaz, N. A., & Mohammed, M. M. (2023). Pain mechanisms in complex regional pain syndrome: a systematic review and meta-analysis of quantitative sensory testing outcomes. Journal of orthopaedic surgery and research, 18(1), 2. https://doi.org/10.1186/s13018-022-03461-2
dc.relation.referencesen5. Melf-Marzi, A., Böhringer, B., Wiehle, M., & Hausteiner-Wiehle, C. (2022). Modern principles of diagnosis and treatment in complex regional pain syndrome. Deutsches Arzteblatt international, 119(51-52), 879-886. https://doi.org/10.3238/arztebl.m2022.0358
dc.relation.referencesen6. NPZP ye odnymy z naybilʹsh zatrebuvanykh v Ukrayini. Shchotyzhnevyk "Apteka", 2023. Retrieved from URL: https://www.apteka.ua/article/669686
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dc.relation.referencesen10. Stasevych, M. & Viktor Zvarych (2022). Medicines of the M02AX group on the Ukrainian market: analysis of the range and search for possible market niches. The role of medical science in implementing innovative medical technologies in the EU countries and Ukraine, 292-306. https://doi.org/10.30525/978-9934-26-199-2-15
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dc.relation.referencesen16. Skoutakis, V. A., Carter, C. A., Mickle, T. R., Smith, V. H., Arkin, C. R., Alissandratos, J., & Petty, D. E. (1988). Review of Diclofenac and evaluation of its place in therapy as a nonsteroidal antiinflammatory agent. Drug Intelligence Clinical Pharmacy, 22(11), 850-859. https://doi.org/10.1177/106002808802201102
dc.relation.referencesen17. Diclofenac uses, dosage and side effects. Drugs.com. (n.d.). Retrieved February 13, 2023, from https://www.drugs.com/diclofenac.html
dc.relation.referencesen18. Novyy bezvodnyy rozchyn dyklofenaku mistsevoho zastosuvannya ta protses yoho pryhotuvannya: pat.97529 Ukrayina. № a201000120. zayavl. 09.06.2008; opubl. 27.02.2012, Byul. No 4.
dc.relation.referencesen19. Farmatsevtychna aerozolʹna kompozytsiya u formi spreyu: pat. 81238 Ukrayina. № u2012 14971; zayavl. 26.12.2012; opubl. 25.06.2013, Byul. No 12.
dc.relation.urihttps://doi.org/10.1093/pm/pnac046
dc.relation.urihttps://doi.org/10.3389/fpsyg.2022.1031923
dc.relation.urihttps://www.apteka.ua/article/573161
dc.relation.urihttps://doi.org/10.1186/s13018-022-03461-2
dc.relation.urihttps://doi.org/10.3238/arztebl.m2022.0358
dc.relation.urihttps://www.apteka.ua/article/669686
dc.relation.urihttps://www.apteka.ua/article/644822
dc.relation.urihttps://doi.org/10.1007/s40272-022-00514-1
dc.relation.urihttps://doi.org/10.46299/isg.2022.mono.med.2.4.1
dc.relation.urihttps://doi.org/10.30525/978-9934-26-199-2-15
dc.relation.urihttp://www.drlz.com.ua
dc.relation.urihttps://tabletki.ua
dc.relation.urihttps://compendium.com.ua
dc.relation.urihttps://doi.org/10.1177/106002808802201102
dc.relation.urihttps://www.drugs.com/diclofenac.html
dc.rights.holder© Національний університет “Львівська політехніка”, 2023
dc.subjectбіль у суглобах або м’язах
dc.subjectспрей для зовнішнього застосування
dc.subjectактивні фармацевтичні інгредієнти
dc.subjectдопоміжні речовини
dc.subjectпринципова технологічна схема
dc.subjectjoint or muscle pain
dc.subjectspray for external use
dc.subjectactive pharmaceutical ingredients
dc.subjectexcipients
dc.subjectprinciple technological scheme
dc.titleDevelopment of the basics of spray technology for external application
dc.title.alternativeРозроблення основ технології одержання спрея для зовнішнього застосування
dc.typeArticle

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Chemistry, Technology and Application of Substances. – 2023. – Vol. 6, No. 2