Development of the basics of production technology of dacarbazine substance with anticancer effect

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dc.citation.epage115
dc.citation.issue2
dc.citation.spage107
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationКаунаський технологічний університет
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.affiliationKaunas University of Technology
dc.contributor.authorСтасевич, М. В.
dc.contributor.authorКусий, М. А.
dc.contributor.authorМіцкевічюс, В.
dc.contributor.authorStasevych, M. V.
dc.contributor.authorKusyi, M. A.
dc.contributor.authorMickevičius, V.
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2026-01-15T13:53:22Z
dc.date.created2024-10-10
dc.date.issued2024-10-10
dc.description.abstractВикладено основи технології виробництва субстанції дакарбазину, яка є діючою речовиною лікарських засобів для лікування метастазної меланоми, лімфоми Hodgkin’s та саркоми м’яких тканин. На основі лабораторної методики здійснено масштабування виробництва як періодичного з потужністю 35 тонн за рік для одержання 1 тонни субстанції з комерційно доступних реагентів. Визначено шість основних технологічних стадій виробництва, що дають змогу одержати продукт з виходом 86 %. На основі матеріальних розрахунків визначено необхідні операційні завантаження компонентів на кожній стадії. Вибрано технологічне обладнання для здійснення процесу. Організацію процесу наведено у технологічній блок-схемі та апаратурно-технологічній схемі.
dc.description.abstractThe basics of the technology for the production of dacarbazine, which is an active ingredient in medicines for the treatment of metastatic melanoma, Hodgkin's lymphoma, and soft tissue sarcoma, are presented. Based on the laboratory methodology, the production was scaled up as a periodic production with a capacity of 35 tons per year to produce 1 ton of the substance from commercially available reagents. Six main technological stages of production were selected, which allowed to obtain a product with a yield of 86 %. Based on material calculations, the required operating loads of components at each stage are determined. The choice of technological equipment for the process is carried out. The organization of the process is presented in the technological flowchart and the equipment and technological scheme.
dc.format.extent107-115
dc.format.pages9
dc.identifier.citationStasevych M. V. Development of the basics of production technology of dacarbazine substance with anticancer effect / M. V. Stasevych, M. A. Kusyi, V. Mickevičius // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2024. — Vol 7. — No 2. — P. 107–115.
dc.identifier.citation2015Stasevych M. V., Mickevičius V. Development of the basics of production technology of dacarbazine substance with anticancer effect // Chemistry, Technology and Application of Substances, Lviv. 2024. Vol 7. No 2. P. 107–115.
dc.identifier.citationenAPAStasevych, M. V., Kusyi, M. A., & Mickevičius, V. (2024). Development of the basics of production technology of dacarbazine substance with anticancer effect. Chemistry, Technology and Application of Substances, 7(2), 107-115. Lviv Politechnic Publishing House..
dc.identifier.citationenCHICAGOStasevych M. V., Kusyi M. A., Mickevičius V. (2024) Development of the basics of production technology of dacarbazine substance with anticancer effect. Chemistry, Technology and Application of Substances (Lviv), vol. 7, no 2, pp. 107-115.
dc.identifier.doihttps://doi.org/10.23939/ctas2024.02.107
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/124444
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry, Technology and Application of Substances, 2 (7), 2024
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dc.relation.referencesen3. Widmer, N., Bardin, C., Chatelut, E., Paci, A., Beijnen, J., Levêque, D., Veal, G., & Astier, A. (2014). Review of therapeutic drug monitoring of anticancer drugs part two – Targeted therapies. European Journal of Cancer, 50(12), 2020–2036. https://doi.org/10.1016/j.ejca.2014.04.015
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dc.relation.referencesen18. Stasevych M. V., Mylyanych A. O., Strelnykov L. S., Krutskykh, T. V., Buchkevych I. R., Zaytsev O. I., Huzova I. O., Strilets O. P., Hladukh Ye. V.,& Novikov V. P. (2018). Tekhnolohichne obladnannya biotekhnolohichnoyi i farmatsevtychnoyi promyslovosti.Lviv: Novyy Svit-2000.
dc.relation.referencesen19. Mylyanych A. O. (2021). Metodychni vkazivky do praktychnykh robit z kursu "Ustatkuvannya ta proektuvannya farmatsevtychnykh vyrobnytstv" dlya studentiv pershoho (bakalavrskoho) rivnya vyshchoyi osvity spetsialnosti 226 Farmatsiya, promyslova farmatsiya. Lviv: Vydavnytstvo NU "Lvivska politekhnika".
dc.relation.referencesen20. Xiao, S., Liu, Z., Liu, Y., & Chen, H. (2015). Optimization of the Synthetic Process of Antineoplastic Drug Dacarbazine. Chinese Journal of Organic Chemistry,35(5), 1161. https://doi.org/10.6023/cjoc201410026
dc.relation.referencesen21. Iradyan,M. A., Iradyan, N. S., Stepanyan, G.M., Arsenyan, F. G., & Garibdzhanyan, B. T. (2010). Antitumor activity of imidazole derivatives: dacarbazine and the new alkylating agent imidazene (Review). Pharmaceutical Chemistry Journal, 44(4), 175–182. https://doi.org/10.1007/s11094-010-0425-6
dc.relation.referencesen22. Suzhou Lanyun Pharmaceutical Technology Co., Ltd. (2019). Method for preparation of dacarbazine. (China Patent No. CN110305067A) European Patent Office. https://worldwide.espacenet.com/patent/search/family/068077204/publication/CN110305067A?q=CN110305067A
dc.relation.referencesen23. Shealy, Y. F., Krauth, C. A., & Montgomery,J. A. (1962). Imidazoles. I. Coupling Reactions of 5- Diazoimidazole-4-carboxamide1,2. The Journal of Organic Chemistry, 27(6), 2150–2154. https://doi.org/10.1021/jo01053a060
dc.relation.urihttps://doi.org/10.1038/nrd4366
dc.relation.urihttps://doi.org/10.1016/j.tips.2012.02.001
dc.relation.urihttps://doi.org/10.1016/j.ejca.2014.04.015
dc.relation.urihttps://www.visiongain.com/?s=cancer&post_type=product
dc.relation.urihttps://doi
dc.relation.urihttps://gco.iarc.fr/en
dc.relation.urihttps://www.kmu.gov.ua/news/melanoma-chomuvazhlyvo-
dc.relation.urihttps://compendium.com.ua/dec/272071/
dc.relation.urihttps://doi.org/10.1016/j.phrs.2007.08.003
dc.relation.urihttps://www.drugs.com/monograph/
dc.relation.urihttps://doi.org/10.1016/bs.podrm.2015.12.002
dc.relation.urihttp://www.drlz.com.ua
dc.relation.urihttps://www.chemicalbook.com
dc.relation.urihttps://www.indiamart.com/proddetail/dacarbazine-api-powder-24311320091.html
dc.relation.urihttps://www.cas.org/solutions/cas-scifinderdiscovery-platform/cas-scifinder
dc.relation.urihttps://doi.org/10.6023/cjoc201410026
dc.relation.urihttps://doi.org/10.1007/s11094-010-0425-6
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/068077204/publication/CN110305067A?q=CN110305067A
dc.relation.urihttps://doi.org/10.1021/jo01053a060
dc.rights.holder© Національний університет „Львівська політехніка“, 2024
dc.subjectмеланома
dc.subjectдакарбазин
dc.subject5-аміно-1Н-імідазол-4-карбоксамід
dc.subjectдіазотування
dc.subjectреакція сполучення
dc.subjectдиметиламін
dc.subjectрозроблення основ технології
dc.subjectтехнологічна схема
dc.subjectmelanoma
dc.subjectdacarbazine
dc.subject5-amino-1H-imidazole-4-carboxamide
dc.subjectdiazotation
dc.subjectcoupling reaction
dc.subjectdimethylamine
dc.subjectdevelopment of the technology basis
dc.subjecttechnological scheme
dc.titleDevelopment of the basics of production technology of dacarbazine substance with anticancer effect
dc.title.alternativeРозроблення основ технології виробництва субстанції дакарбазину з протираковою дією
dc.typeArticle

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Chemistry, Technology and Application of Substances. – 2024. – Vol. 7, No. 2