Molecular principles of the spontaneous mutagenesis in DNA

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Date

2016

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Lviv Polytechnic Publishing House

Abstract

Reported results are crucial for understanding of the microstructural mechanisms of the spontaneous transitions and transversions, since they allow us to explain, from the one side, the origin of the mutagenic tautomers at the separation of the DNA strands before its replication and, from the other side, in what way occurs the adaptation of the incorrect purine·pyrimidine, purine·purine and pyrimidine·pyrimidine wobble pairs to the enzymatically competent sizes in the recognition pocket of the high-fidelity DNA-polymerase.

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Keywords

spontaneous point mutagenesis, incorporation and replication errors, tautomerisation, pairs of nucleotide bases, enzymatically-competent conformation, hydrogen bond, quantum chemistry

Citation

Brovarets O. Molecular principles of the spontaneous mutagenesis in DNA / Ol’ha Brovarets // Litteris et Artibus : proceedings of the 6th International youth science forum, November 24–26, 2016, Lviv, Ukraine / Lviv Polytechnic National University. – Lviv : Lviv Polytechnic Publishing House, 2016. – P. 23–30. – Bibliography: 69 titles.

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