Композиції дисульфіраму на основі біополімерів з графітовими матеріалами

Simple item page
dc.citation.epage110
dc.citation.issue1
dc.citation.journalTitleХімія, технологія речовин та їх застосування
dc.citation.spage105
dc.citation.volume8
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.authorЗаярнюк, Н. Л.
dc.contributor.authorСидоряк, О. І.
dc.contributor.authorКричковська, А. М.
dc.contributor.authorГрабович, Б. А.
dc.contributor.authorZayarnyuk, N. L.
dc.contributor.authorSydoriak, O. I.
dc.contributor.authorKrychkovska, A. M.
dc.contributor.authorGrabovych, B. A.
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2026-03-30T09:52:21Z
dc.date.created2025-02-27
dc.date.issued2025-02-27
dc.description.abstractНа основі бібліометричного аналізу наукових публікацій, патентів, інтернет-ресурсів та раніше опублікованих результатів власних досліджень обґрунтовано доцільність розробки нової композиції дисульфіраму на основі графітових матеріалів з біополімерами. Вибрано оптимальні методики та одержано зразки нонокомпозицій ОГ-А-ДС (оксид графену-альбумін дисульфірам) у вигляді водної дисперсії, а також зразки композицій ТРГ-БП (терморозширений графіт-біополімер), які будуть потенційними носіями для лікарських засобів.
dc.description.abstractBased on the bibliometric analysis of scientific publications, patents, Internet resources and previously published results of our own research, the feasibility of developing a new disulfiram composition based on graphite materials with biopolymers was substantiated. Optimal methods were selected and samples of OG-A-DS (graphene oxide-albumin-disulfiram) nanocompositions were obtained in the form of an aqueous dispersion, as well as samples of TRG-BP (thermally expanded graphite-biopolymer) compositions, which will be potential carriers for drugs.
dc.format.extent105-110
dc.format.pages6
dc.identifier.citationКомпозиції дисульфіраму на основі біополімерів з графітовими матеріалами / Н. Л. Заярнюк, О. І. Сидоряк, А. М. Кричковська, Б. А. Грабович // Хімія, технологія речовин та їх застосування. — Львів : Видавництво Львівської політехніки, 2025. — Том 8. — № 1. — С. 105–110.
dc.identifier.citationenDisulfiram compositions based on biopolymers with graphite materials / N. L. Zayarnyuk, O. I. Sydoriak, A. M. Krychkovska, B. A. Grabovych // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2025. — Vol 8. — No 1. — P. 105–110.
dc.identifier.doidoi.org/10.23939/ctas2025.01.105
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/124849
dc.language.isouk
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofХімія, технологія речовин та їх застосування, 1 (8), 2025
dc.relation.ispartofChemistry, Technology and Application of Substances, 1 (8), 2025
dc.relation.references1. Afzal, O., Altamimi, A. S. A., Nadeem, M. S., Alzarea, S. I., Almalki, W. H., Tariq, A., Mubeen, B., Murtaza, B. N., Iftikhar, S., Riaz, N., & Kazmi, I. (2022). Nanoparticles in Drug Delivery: From History to Therapeutic Applications. Nanomaterials, 12(24), 4494. https://doi.org/10.3390/nano12244494
dc.relation.references2. Wang, Z., Colombi Ciacchi, L., & Wei, G. (2017). Recent Advances in the Synthesis of Graphene-Based Nanomaterials for Controlled Drug Delivery. Applied Sciences, 7(11), 1175. https://doi.org/10.3390/app7111175
dc.relation.references3. Bell R.G., Smith H.W. (1949). Preliminary report on clinical trials of antabuse. Can. Med. Assoc. J. 60. P. 286-288.
dc.relation.references4. McMahon A, Chen W, Li F. (2020). Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy. J Control Release. 10;319:352-359. https://DOI:10.1016/j.jconrel.2020.01.001.
dc.relation.references5. Likuvannya alkoholizmu v domashnikh umovakh. (24.06.2022). Klinika «Renesans Kyyiv». URL: https://www.rs-clinic.com.ua/uk/alkogolizm (data zvernennya 29.01.2025)
dc.relation.references6. Sobetov B., Zayarnyuk N., Krychrovska ., Kurka M., Hass J., Fedorova O., Novikov V. (2016). Injecting prolongs of disulfiram or quality of life in addictive disorders. Monographic series “Promoting healthy lifestyle”, Volume 1, Human health: realities and prospects, edited by N. V. (pp.268-276). Skotna, Drohobych: Posvit,
dc.relation.references7. Fillmore, N., Bell, S., Shen, C., Nguyen, V., La, J., Dubreuil, M., Strymish, J., Brophy, M., Mehta, G., Wu, H., Lieberman, J., Do, N., & Sander, C. (2021). Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study. Plos One, 16, Article 10. https://doi.org/10.1371/journal.pone.0259061
dc.relation.references8. Nagai, N., Yoshioka, C., Mano, Y., Tnabe, W., Ito, Y., Okamoto, N., & Shimomura, Y. (2015). A nanoparticle formulation of disulfiram prolongs corneal residence time of the drug and reduces intraocular pressure. Experimental Eye Research, 132, 115–123. https://doi.org/10.1016/J.EXER.2015.01.022
dc.relation.references9. Nagai N. (2016). Yakugaku zasshi. Journal of the Pharmaceutical Society of Japan, 136(10), 1385–1390. https://doi.org/10.1248/yakushi.16-00089
dc.relation.references10. Kang, X., Jadhav, S., Annaji, M., Huang, C.-H., Amin, R., Shen, J., Ashby, C. R., Jr., Tiwari, A. K., Babu, R. J., & Chen, P. (2023). Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems. Pharmaceutics, 15(6), 1567. https://doi.org/10.3390/pharmaceutics15061567
dc.relation.references11. Song, L., Yang, Y., Hu, H. et al. (2024). Thermodynamic study on expanded graphite-based multifunctional composite phase change materials for personal thermal management and medical protection. J Therm Anal Calorim 149, 595–607 https://doi.org/10.1007/s10973-023-12662-8
dc.relation.references12. Viprya, P., Kumar, D., & Kowshik, S. (2023). Study of Different Properties of Graphene Oxide (GO) and Reduced Graphene Oxide (rGO). Engineering Proceedings, 59(1), 84. https://doi.org/10.3390/engproc2023059084
dc.relation.references13. Tekhnolohiya otrymannya hrafenu ta hrafenovykh oksydiv. (2021, kvitenʹ). Ukrayinsʹkyy derzhavnyy khimiko-tekhnolohichnyy universytet. URL: https://udhtu.edu.ua/wp-content/uploads/2021/04/colyaris.pdf. (data zvernennya 29.01.2025)
dc.relation.references14. Zou Zhengguang. (2013). Method for synthesizing graphene oxide by ultrasonic assistance Hummers method. CN102153075B. China. URL: https://patents.google.com/patent/CN102153075B/en (дата звернення 29.01.2025)
dc.relation.references15. Yang Huanghao, Jin Guixiao, Li JuanWu, LingjieGuo Shanshan. (2014). Graphene oxide drug carrier as well as preparation method and application thereof. CN103110957B. China. URL: https://patents.google.com/patent/CN103110957B/en (дата звернення 29.01.2025)
dc.relation.references16. Mike Roemmler. (2002). Method of making expanded graphite with high purity and related products. US20020168314A1. United States. URL: https://patents.google.com/patent/US20020168314A1/en (дата звернення 29.01.2025)
dc.relation.references17. Kang, X., Jadhav, S., Annaji, M., Huang, C.-H., Amin, R., Shen, J., Ashby, C. R., Jr., Tiwari, A. K., Babu, R. J., & Chen, P. (2023). Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems. Pharmaceutics, 15(6), 1567. https://doi.org/10.3390/pharmaceutics15061567
dc.relation.references18. Nathalie Karaky, Andrew Kirby, McBain A. J., Butler J. A., Mohamed El Mohtadi, Banks C.E. & Whitehead K. A. (2020). Metal ions and graphene-based compounds as alternative treatment options for burn wounds infected by antibiotic-resistant Pseudomonas aeruginosa. Arch Microbiol, 202, 995–1004 https://doi.org/10.1007/s00203-019-01803-z
dc.relation.references19. Yu Ma, Dongchen Bai, Xinjun Hu, Nan Ren, Wensheng Gao, Songbo Chen, Huqiang Chen, Yue Lu, Jiangong Li & Yongxiao Bai. (2018). Robust and Antibacterial Polymer/Mechanically Exfoliated Graphene Nanocomposite Fibers for Biomedical Applications. ACS Applied Materials & Interfaces. 10(3), 3002-3010.
dc.relation.referencesen1. Afzal, O., Altamimi, A. S. A., Nadeem, M. S., Alzarea, S. I., Almalki, W. H., Tariq, A., Mubeen, B., Murtaza, B. N., Iftikhar, S., Riaz, N., & Kazmi, I. (2022). Nanoparticles in Drug Delivery: From History to Therapeutic Applications. Nanomaterials, 12(24), 4494. https://doi.org/10.3390/nano12244494
dc.relation.referencesen2. Wang, Z., Colombi Ciacchi, L., & Wei, G. (2017). Recent Advances in the Synthesis of Graphene-Based Nanomaterials for Controlled Drug Delivery. Applied Sciences, 7(11), 1175. https://doi.org/10.3390/app7111175
dc.relation.referencesen3. Bell R.G., Smith H.W. (1949). Preliminary report on clinical trials of antabuse. Can. Med. Assoc. J. 60. P. 286-288.
dc.relation.referencesen4. McMahon A, Chen W, Li F. (2020). Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy. J Control Release. 10;319:352-359. https://DOI:10.1016/j.jconrel.2020.01.001.
dc.relation.referencesen5. Likuvannya alkoholizmu v domashnikh umovakh. (24.06.2022). Klinika "Renesans Kyyiv". URL: https://www.rs-clinic.com.ua/uk/alkogolizm (data zvernennya 29.01.2025)
dc.relation.referencesen6. Sobetov B., Zayarnyuk N., Krychrovska ., Kurka M., Hass J., Fedorova O., Novikov V. (2016). Injecting prolongs of disulfiram or quality of life in addictive disorders. Monographic series "Promoting healthy lifestyle", Volume 1, Human health: realities and prospects, edited by N. V. (pp.268-276). Skotna, Drohobych: Posvit,
dc.relation.referencesen7. Fillmore, N., Bell, S., Shen, C., Nguyen, V., La, J., Dubreuil, M., Strymish, J., Brophy, M., Mehta, G., Wu, H., Lieberman, J., Do, N., & Sander, C. (2021). Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study. Plos One, 16, Article 10. https://doi.org/10.1371/journal.pone.0259061
dc.relation.referencesen8. Nagai, N., Yoshioka, C., Mano, Y., Tnabe, W., Ito, Y., Okamoto, N., & Shimomura, Y. (2015). A nanoparticle formulation of disulfiram prolongs corneal residence time of the drug and reduces intraocular pressure. Experimental Eye Research, 132, 115–123. https://doi.org/10.1016/J.EXER.2015.01.022
dc.relation.referencesen9. Nagai N. (2016). Yakugaku zasshi. Journal of the Pharmaceutical Society of Japan, 136(10), 1385–1390. https://doi.org/10.1248/yakushi.16-00089
dc.relation.referencesen10. Kang, X., Jadhav, S., Annaji, M., Huang, C.-H., Amin, R., Shen, J., Ashby, C. R., Jr., Tiwari, A. K., Babu, R. J., & Chen, P. (2023). Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems. Pharmaceutics, 15(6), 1567. https://doi.org/10.3390/pharmaceutics15061567
dc.relation.referencesen11. Song, L., Yang, Y., Hu, H. et al. (2024). Thermodynamic study on expanded graphite-based multifunctional composite phase change materials for personal thermal management and medical protection. J Therm Anal Calorim 149, 595–607 https://doi.org/10.1007/s10973-023-12662-8
dc.relation.referencesen12. Viprya, P., Kumar, D., & Kowshik, S. (2023). Study of Different Properties of Graphene Oxide (GO) and Reduced Graphene Oxide (rGO). Engineering Proceedings, 59(1), 84. https://doi.org/10.3390/engproc2023059084
dc.relation.referencesen13. Tekhnolohiya otrymannya hrafenu ta hrafenovykh oksydiv. (2021, kvitenʹ). Ukrayinsʹkyy derzhavnyy khimiko-tekhnolohichnyy universytet. URL: https://udhtu.edu.ua/wp-content/uploads/2021/04/colyaris.pdf. (data zvernennya 29.01.2025)
dc.relation.referencesen14. Zou Zhengguang. (2013). Method for synthesizing graphene oxide by ultrasonic assistance Hummers method. CN102153075B. China. URL: https://patents.google.com/patent/CN102153075B/en (Date of appeal 29.01.2025)
dc.relation.referencesen15. Yang Huanghao, Jin Guixiao, Li JuanWu, LingjieGuo Shanshan. (2014). Graphene oxide drug carrier as well as preparation method and application thereof. CN103110957B. China. URL: https://patents.google.com/patent/CN103110957B/en (Date of appeal 29.01.2025)
dc.relation.referencesen16. Mike Roemmler. (2002). Method of making expanded graphite with high purity and related products. US20020168314A1. United States. URL: https://patents.google.com/patent/US20020168314A1/en (Date of appeal 29.01.2025)
dc.relation.referencesen17. Kang, X., Jadhav, S., Annaji, M., Huang, C.-H., Amin, R., Shen, J., Ashby, C. R., Jr., Tiwari, A. K., Babu, R. J., & Chen, P. (2023). Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems. Pharmaceutics, 15(6), 1567. https://doi.org/10.3390/pharmaceutics15061567
dc.relation.referencesen18. Nathalie Karaky, Andrew Kirby, McBain A. J., Butler J. A., Mohamed El Mohtadi, Banks C.E. & Whitehead K. A. (2020). Metal ions and graphene-based compounds as alternative treatment options for burn wounds infected by antibiotic-resistant Pseudomonas aeruginosa. Arch Microbiol, 202, 995–1004 https://doi.org/10.1007/s00203-019-01803-z
dc.relation.referencesen19. Yu Ma, Dongchen Bai, Xinjun Hu, Nan Ren, Wensheng Gao, Songbo Chen, Huqiang Chen, Yue Lu, Jiangong Li & Yongxiao Bai. (2018). Robust and Antibacterial Polymer/Mechanically Exfoliated Graphene Nanocomposite Fibers for Biomedical Applications. ACS Applied Materials & Interfaces. 10(3), 3002-3010.
dc.relation.urihttps://doi.org/10.3390/nano12244494
dc.relation.urihttps://doi.org/10.3390/app7111175
dc.relation.urihttps://DOI:10.1016/j.jconrel.2020.01.001
dc.relation.urihttps://www.rs-clinic.com.ua/uk/alkogolizm
dc.relation.urihttps://doi.org/10.1371/journal.pone.0259061
dc.relation.urihttps://doi.org/10.1016/J.EXER.2015.01.022
dc.relation.urihttps://doi.org/10.1248/yakushi.16-00089
dc.relation.urihttps://doi.org/10.3390/pharmaceutics15061567
dc.relation.urihttps://doi.org/10.1007/s10973-023-12662-8
dc.relation.urihttps://doi.org/10.3390/engproc2023059084
dc.relation.urihttps://udhtu.edu.ua/wp-content/uploads/2021/04/colyaris.pdf
dc.relation.urihttps://patents.google.com/patent/CN102153075B/en
dc.relation.urihttps://patents.google.com/patent/CN103110957B/en
dc.relation.urihttps://patents.google.com/patent/US20020168314A1/en
dc.relation.urihttps://doi.org/10.1007/s00203-019-01803-z
dc.rights.holder© Національний університет “Львівська політехніка”, 2025
dc.subjectбіополімери
dc.subjectнаноносії
dc.subjectоксид графену
dc.subjectтерморозширений графіт
dc.subjectдисульфірам
dc.subjectфармація
dc.subjectтехнологія ліків
dc.subjectbiopolymers
dc.subjectnanocarriers
dc.subjectgraphene oxide
dc.subjectexpanded graphite
dc.subjectdisulfiram
dc.subjectpharmacy
dc.subjectdrug technology
dc.titleКомпозиції дисульфіраму на основі біополімерів з графітовими матеріалами
dc.title.alternativeDisulfiram compositions based on biopolymers with graphite materials
dc.typeArticle

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
2025v8n1_Zayarnyuk_N_L-Disulfiram_compositions_105-110.pdf
Size:
785.82 KB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
2025v8n1_Zayarnyuk_N_L-Disulfiram_compositions_105-110__COVER.png
Size:
481.61 KB
Format:
Portable Network Graphics
Download

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.9 KB
Format:
Plain Text
Description:
Download

Collections

Chemistry, Technology and Application of Substances. – 2025. – Vol. 8, No. 1