Development of the technological basis for the production of aceclofenac

Simple item page
dc.citation.epage147
dc.citation.issue7
dc.citation.journalTitleХімія, технологія речовин та їх застосування
dc.citation.spage140
dc.citation.volume1
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationКаунаський технологічний університет
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.affiliationKaunas University of Technology
dc.contributor.authorСтасевич, М. В.
dc.contributor.authorФульмес, М. С.
dc.contributor.authorЙонускене, І.
dc.contributor.authorStasevych, M. V.
dc.contributor.authorFulmes, M. S.
dc.contributor.authorJonuškienė, I.
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2025-09-12T07:59:48Z
dc.date.created2024-02-27
dc.date.issued2024-02-27
dc.description.abstractПрепарати ацеклофенаку широко використовують у світовій терапевтичній практиці запальних та больових станів для лікування остеоартриту, ревматоїдного артриту та анкілозуючого спондиліту в різних лікарських формах. Розроблено основи технології вітчизняного промислового періодичного виробництва ацеклофенаку потужністю 110 т/рік для одержання низки ефективних лікарських засобів. Запропоновано виробництво з п’яти технологічних стадій, яке дасть змогу виробляти вітчизняний продукт з високим виходом (~91 %) з комерційно доступних реагентів. Виконано матеріальні розрахунки для визначення норм витрат сировини. Вибрано типи та визначено кількість обладнання. Запропоновано принципову апаратурно-технологічну схему та технологічну блок-схему одержання ацеклофенаку.
dc.description.abstractAceclofenac drugs are widely used in the global therapeutic practice of inflammatory and painful conditions for the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in various dosage forms. The basics of the technology of domestic industrial batch production of aceclofenac with a capacity of 110 t/year for the production of a number of effective medicines have been developed. A five-stage production process is proposed that will allow the production of a domestic product with a high yield (~91 %) from commercially available reagents. Material calculations were carried out to determine the consumption rates of raw materials. The types of equipment were selected, and the number of equipment was determined. The basic technological scheme and technological flowchart for the production of aceclofenac are proposed.
dc.format.extent140-147
dc.format.pages8
dc.identifier.citationStasevych M. V. Development of the technological basis for the production of aceclofenac / M. V. Stasevych, M. S. Fulmes, I. Jonuškienė // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2024. — Vol 1. — No 7. — P. 140–147.
dc.identifier.citationenStasevych M. V. Development of the technological basis for the production of aceclofenac / M. V. Stasevych, M. S. Fulmes, I. Jonuškienė // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2024. — Vol 1. — No 7. — P. 140–147.
dc.identifier.doidoi.org/10.23939/ctas2024.01.140
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/111737
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofХімія, технологія речовин та їх застосування, 7 (1), 2024
dc.relation.ispartofChemistry, Technology and Application of Substances, 7 (1), 2024
dc.relation.references1. Iupac, Fischer, J., & Ganellin, C. R. (2006). Analogue-based drug discovery. John Wiley & Sons. https://doi.org/10.1002/3527608001
dc.relation.references2. Carron, H., Korbon, G. A., & Rowlingson, J. C. (1984). Regional anesthesia: techniques and clinical applications. https://ci.nii.ac.jp/ncid/BA04431981
dc.relation.references3. Bort, R., Ponsoda, X., Carrasco, E., Gómez-Lechón, M. J., & Castell, J. V. (1996). Metabolism of aceclofenac in humans. Drug metabolism and disposition: the biological fate of chemicals, 24(8), 834-841.
dc.relation.references4. Karmoker, J. R., Sarkar, S., Joydhar, P., & Chowdhury, S. F. (2016). Comparative in vitro equivalence evaluation of some Aceclofenac generic tablets marketed in Bangladesh. The Pharma Innovation Journal, 5(3), 03-07. https://www.thepharmajournal.com/archives/2016/vol5issue3/PartA/5-1-7.pdf
dc.relation.references5. Legrand, E. (2004). Aceclofenac in the management of inflammatory pain. Expert Opinion on Pharmacotherapy, 5(6), 1347-1357. https://doi.org/10.1517/14656566.5.6.1347
dc.relation.references6. Dooley, M., Spencer, C. M., & Dunn, C. J. (2001). Aceclofenac. Drugs, 61(9), 1351-1378. https://doi.org/10.2165/00003495-200161090-00012
dc.relation.references7. Aceclofenac. (2023). Drugs.com. https://www.drugs.com/international/aceclofenac.html
dc.relation.references8. Hinz, B., Auge, D., Rau, T., Rietbrock, S., Brune, K., & Werner, U. (2003). Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high‐performance liquid chromatography. Biomedical Chromatography, 17(4), 268-275. https://doi.org/10.1002/bmc.243
dc.relation.references9. Aceclofenac. (2016). In Elsevier eBooks (p. 18). https://doi.org/10.1016/b978-0-444-53717-1.00214-6
dc.relation.references10. Schiermeier, S., & Schmidt, P. (2002). Fast dispersible ibuprofen tablets. European Journal of Pharmaceutical Sciences, 15(3), 295-305. https://doi.org/10.1016/s0928-0987(02)00011-8
dc.relation.references11. Patrick K., Sang K.W. (2001). The method of manufacturing a lyophilized dosage form (U.S. Patent No. 20110229573A1. U.S. Patent and Trade-mark Office. https://worldwide.espacenet.com/patent/search/family/044169183/publication/US2011229573A1?q=US%2020110229573A1
dc.relation.references12. Patel, D. K., Dasgupta, S., Dey, S., Ramani, Y. R., Ray, S., & Mazumder, B. (2012). Nanostructured Lipid Carriers (NLC)-Based gel for topical delivery of Aceclofenac: preparation, characterization and in vivo evaluation. Scientia Pharmaceutica, 80(3), 749-764. https://doi.org/10.3797/scipharm.1202-12
dc.relation.references13. Derzhavnyy reyestr likarsʹkykh zasobiv Ukrayiny. URL: http://www.drlz.com.ua (Retrieved: 05.01.2024).
dc.relation.references14. PharmaCompass.com. (2024). Aceclofenac API Manufacturers | Suppliers | Exporters | Pharmacompass.com. https://www.pharmacompass.com/listed-activepharmaceutical-ingredients/aceclofenac
dc.relation.references15. CAS SciFinderⁿ - Chemical Compound Database. CAS. (2024). Retrieved December 31, 2023, from https://www.cas.org/solutions/cas-scifinder-discovery-platform/cas-scifinder
dc.relation.references16. Sydorov Yu.I., Chuyeshov V.I., & Novikov V.P. (2009). Protsesy i aparaty khimiko-farmatsevtychnoyi promyslovosti. Vinnytsya: Nova Knyha.
dc.relation.references17. Stasevych M.V., Mylyanych A.O., Strelnykov L.S., Krutskykh, T.V., Buchkevych I.R., Zaytsev O.I., Huzova I.O., Strilets O.P., Hladukh YE.V., & Novikov V.P. (2018). Tekhnolohichne obladnannya biotekhnolohichnoyi i farmatsevtychnoyi promyslovosti. Lʹviv: Novyy Svit-2000.
dc.relation.references18. Mylyanych A.O. (2021). Metodychni vkazivky do praktychnykh robit z kursu "Ustatkuvannya ta proektuvannya farmatsevtychnykh vyrobnytstv" dlya studentiv pershoho (bakalavrsʹkoho) rivnya vyshchoyi osvity spetsialʹnosti 226 Farmatsiya, promyslova farmatsiya. Lviv : Vydavnytstvo NU «Lvivska politekhnika».
dc.relation.references19. Lunan Pharmaceutical Group Corp. (2018). Preparation of aceclofenac (China Patent No. CN108383745A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/063071328/publication/CN108383745A?q=CN108383745A
dc.relation.references20. Zhejiang University of Technology (2019). Preparation method of aceclofenac, (China Patent No. CN110143891 A). European Patent Office. No. CN110143891 A). https://worldwide.espacenet.com/patent/search/family/067592402/publication/CN110143891A?q=CN110143891A
dc.relation.references21. J.B. Chemicals & Pharmaceuticals Ltd. (2005). Process for the preparation of [2-(2,6-dichloroanilino)phenyl]acetoxyacetic acid via hydrolysis of the corresponding tert-butyl ester using styrene-divinylbenzene copolymer sulfonic acids, WO2005073163 A1. World Intellectual Property Organization. https://worldwide.espacenet.com/patent/search/family/034814929/publication/WO2005073163A1?q=WO2005073163%20A1
dc.relation.references22. Prodesfarma SA. (1994). Phenylacetic acid derivatives, process for the preparation thereof and corresponding use (Canada Patent No. CA2111169A1). European Patent Office. https://worldwide.espacenet.com/patent/search/family/008279093/publication/CA2111169A1?q=CA2111169A1
dc.relation.references23. IPCA Laboratories Limited (2007). An improved process for the manufacture of 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetyl derivatives. (India Patent No. IN2004MU00640 A).
dc.relation.references24. Dae Hwa Pharma. Co., Ltd. (2000). Process for preparing 2-[[2-[(2,6-dichlorophenyl)amino]phenyl]acetoxy]acetic acid. (Korea Patent No. KR2000026534 A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/019554832/publication/KR20000026534A?q=KR20000026534A
dc.relation.references25. K. J. Chul, N. S. Keon, C. J. Kun, C. B. Ra, C. H. Young. (1999). Preparation of aceclofenac haloethyl esters as antiinflammatories and aceclofenac intermediates (Patent No. WO9962865 A1). World Intellectual Property Organization. WO9962865 A1). https://worldwide.espacenet.com/patent/search/family/019538371/publication/WO9962865A1?q=WO9962865%20A1
dc.relation.references26. Patra, S. K., Mondal, P., Mandal, S., Ghosh, S., & Deb, S. (2015). Ultrasound-Promoted Synthesis of Aceclofenac. Journal of Scientific & Industrial Research, 74, 582-583. http://nopr.niscair.res.in/bitstream/123456789/32833/1/JSIR%2074%2810%29%20582-583.pdf
dc.relation.references27. Zhang H. (2008). Method for preparing aceclofenac (China Patent No. CN101215243 A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/039621763/publication/CN101215243A?q=CN101215243%20A
dc.relation.references28. Qin B., Chen J., & Zhang Y. (2008). Synthesis of aceclofenac, Zhongguo Yiyao Gongye Zazhi, 39, 408-409.
dc.relation.references29. Yang J., Gan B., Zhang Y., Cheng W., & Cao Z. (2006). Synthesis of aceclofenac, Zhongguo Yaoshi (Wuhan, China), 9, 1113-1114.
dc.relation.references30. Ningbo Smart Pharmaceutical Co., Ltd. (2020). Method for industrial preparation of 2-[[2-[(2,6-dichlorophenyl)amino]phenyl]acetoxy]acetic acid (China Patent No. CN111848426 A). European Patent Office.Patent No. CN111848426 A). https://worldwide.espacenet.com/patent/search/family/073001820/publication/CN111848426A?q=CN111848426%20A
dc.relation.references31. Korea Biochem Pharm. Inc. (2020). Manufacturing method of aceclofenac and pharmaceutical preparations containing it (Korea Patent No. KR2020098992A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/072235748/publication/KR20200098992A?q=KR20200098992A
dc.relation.references32. Zhejiang University of Technology (2019). Preparation method of aceclofenac (China Patent No. CN110143891 A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/067592402/publication/CN110143891A?q=CN110143891%20A
dc.relation.references33. Amoli Organics Pvt. Ltd. (2015). An improved process for preparation of [2-(2,6- dichloroanilino)phenyl]acetoxy acetic acid (India Patent No. IN2013MU00480 A).
dc.relation.references34. Bisel, P., Al‐Momani, L. A., & Müller, M. (2008). The tert-butyl group in chemistry and biology. Organic and Biomolecular Chemistry, 6(15), 2655. https://doi.org/10.1039/b800083b
dc.relation.referencesen1. Iupac, Fischer, J., & Ganellin, C. R. (2006). Analogue-based drug discovery. John Wiley & Sons. https://doi.org/10.1002/3527608001
dc.relation.referencesen2. Carron, H., Korbon, G. A., & Rowlingson, J. C. (1984). Regional anesthesia: techniques and clinical applications. https://ci.nii.ac.jp/ncid/BA04431981
dc.relation.referencesen3. Bort, R., Ponsoda, X., Carrasco, E., Gómez-Lechón, M. J., & Castell, J. V. (1996). Metabolism of aceclofenac in humans. Drug metabolism and disposition: the biological fate of chemicals, 24(8), 834-841.
dc.relation.referencesen4. Karmoker, J. R., Sarkar, S., Joydhar, P., & Chowdhury, S. F. (2016). Comparative in vitro equivalence evaluation of some Aceclofenac generic tablets marketed in Bangladesh. The Pharma Innovation Journal, 5(3), 03-07. https://www.thepharmajournal.com/archives/2016/vol5issue3/PartA/5-1-7.pdf
dc.relation.referencesen5. Legrand, E. (2004). Aceclofenac in the management of inflammatory pain. Expert Opinion on Pharmacotherapy, 5(6), 1347-1357. https://doi.org/10.1517/14656566.5.6.1347
dc.relation.referencesen6. Dooley, M., Spencer, C. M., & Dunn, C. J. (2001). Aceclofenac. Drugs, 61(9), 1351-1378. https://doi.org/10.2165/00003495-200161090-00012
dc.relation.referencesen7. Aceclofenac. (2023). Drugs.com. https://www.drugs.com/international/aceclofenac.html
dc.relation.referencesen8. Hinz, B., Auge, D., Rau, T., Rietbrock, S., Brune, K., & Werner, U. (2003). Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high‐performance liquid chromatography. Biomedical Chromatography, 17(4), 268-275. https://doi.org/10.1002/bmc.243
dc.relation.referencesen9. Aceclofenac. (2016). In Elsevier eBooks (p. 18). https://doi.org/10.1016/b978-0-444-53717-1.00214-6
dc.relation.referencesen10. Schiermeier, S., & Schmidt, P. (2002). Fast dispersible ibuprofen tablets. European Journal of Pharmaceutical Sciences, 15(3), 295-305. https://doi.org/10.1016/s0928-0987(02)00011-8
dc.relation.referencesen11. Patrick K., Sang K.W. (2001). The method of manufacturing a lyophilized dosage form (U.S. Patent No. 20110229573A1. U.S. Patent and Trade-mark Office. https://worldwide.espacenet.com/patent/search/family/044169183/publication/US2011229573A1?q=US%2020110229573A1
dc.relation.referencesen12. Patel, D. K., Dasgupta, S., Dey, S., Ramani, Y. R., Ray, S., & Mazumder, B. (2012). Nanostructured Lipid Carriers (NLC)-Based gel for topical delivery of Aceclofenac: preparation, characterization and in vivo evaluation. Scientia Pharmaceutica, 80(3), 749-764. https://doi.org/10.3797/scipharm.1202-12
dc.relation.referencesen13. Derzhavnyy reyestr likarsʹkykh zasobiv Ukrayiny. URL: http://www.drlz.com.ua (Retrieved: 05.01.2024).
dc.relation.referencesen14. PharmaCompass.com. (2024). Aceclofenac API Manufacturers | Suppliers | Exporters | Pharmacompass.com. https://www.pharmacompass.com/listed-activepharmaceutical-ingredients/aceclofenac
dc.relation.referencesen15. CAS SciFinderⁿ - Chemical Compound Database. CAS. (2024). Retrieved December 31, 2023, from https://www.cas.org/solutions/cas-scifinder-discovery-platform/cas-scifinder
dc.relation.referencesen16. Sydorov Yu.I., Chuyeshov V.I., & Novikov V.P. (2009). Protsesy i aparaty khimiko-farmatsevtychnoyi promyslovosti. Vinnytsya: Nova Knyha.
dc.relation.referencesen17. Stasevych M.V., Mylyanych A.O., Strelnykov L.S., Krutskykh, T.V., Buchkevych I.R., Zaytsev O.I., Huzova I.O., Strilets O.P., Hladukh YE.V., & Novikov V.P. (2018). Tekhnolohichne obladnannya biotekhnolohichnoyi i farmatsevtychnoyi promyslovosti. Lʹviv: Novyy Svit-2000.
dc.relation.referencesen18. Mylyanych A.O. (2021). Metodychni vkazivky do praktychnykh robit z kursu "Ustatkuvannya ta proektuvannya farmatsevtychnykh vyrobnytstv" dlya studentiv pershoho (bakalavrsʹkoho) rivnya vyshchoyi osvity spetsialʹnosti 226 Farmatsiya, promyslova farmatsiya. Lviv : Vydavnytstvo NU "Lvivska politekhnika".
dc.relation.referencesen19. Lunan Pharmaceutical Group Corp. (2018). Preparation of aceclofenac (China Patent No. CN108383745A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/063071328/publication/CN108383745A?q=CN108383745A
dc.relation.referencesen20. Zhejiang University of Technology (2019). Preparation method of aceclofenac, (China Patent No. CN110143891 A). European Patent Office. No. CN110143891 A). https://worldwide.espacenet.com/patent/search/family/067592402/publication/CN110143891A?q=CN110143891A
dc.relation.referencesen21. J.B. Chemicals & Pharmaceuticals Ltd. (2005). Process for the preparation of [2-(2,6-dichloroanilino)phenyl]acetoxyacetic acid via hydrolysis of the corresponding tert-butyl ester using styrene-divinylbenzene copolymer sulfonic acids, WO2005073163 A1. World Intellectual Property Organization. https://worldwide.espacenet.com/patent/search/family/034814929/publication/WO2005073163A1?q=WO2005073163%20A1
dc.relation.referencesen22. Prodesfarma SA. (1994). Phenylacetic acid derivatives, process for the preparation thereof and corresponding use (Canada Patent No. CA2111169A1). European Patent Office. https://worldwide.espacenet.com/patent/search/family/008279093/publication/CA2111169A1?q=CA2111169A1
dc.relation.referencesen23. IPCA Laboratories Limited (2007). An improved process for the manufacture of 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetyl derivatives. (India Patent No. IN2004MU00640 A).
dc.relation.referencesen24. Dae Hwa Pharma. Co., Ltd. (2000). Process for preparing 2-[[2-[(2,6-dichlorophenyl)amino]phenyl]acetoxy]acetic acid. (Korea Patent No. KR2000026534 A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/019554832/publication/KR20000026534A?q=KR20000026534A
dc.relation.referencesen25. K. J. Chul, N. S. Keon, C. J. Kun, C. B. Ra, C. H. Young. (1999). Preparation of aceclofenac haloethyl esters as antiinflammatories and aceclofenac intermediates (Patent No. WO9962865 A1). World Intellectual Property Organization. WO9962865 A1). https://worldwide.espacenet.com/patent/search/family/019538371/publication/WO9962865A1?q=WO9962865%20A1
dc.relation.referencesen26. Patra, S. K., Mondal, P., Mandal, S., Ghosh, S., & Deb, S. (2015). Ultrasound-Promoted Synthesis of Aceclofenac. Journal of Scientific & Industrial Research, 74, 582-583. http://nopr.niscair.res.in/bitstream/123456789/32833/1/JSIR%2074%2810%29%20582-583.pdf
dc.relation.referencesen27. Zhang H. (2008). Method for preparing aceclofenac (China Patent No. CN101215243 A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/039621763/publication/CN101215243A?q=CN101215243%20A
dc.relation.referencesen28. Qin B., Chen J., & Zhang Y. (2008). Synthesis of aceclofenac, Zhongguo Yiyao Gongye Zazhi, 39, 408-409.
dc.relation.referencesen29. Yang J., Gan B., Zhang Y., Cheng W., & Cao Z. (2006). Synthesis of aceclofenac, Zhongguo Yaoshi (Wuhan, China), 9, 1113-1114.
dc.relation.referencesen30. Ningbo Smart Pharmaceutical Co., Ltd. (2020). Method for industrial preparation of 2-[[2-[(2,6-dichlorophenyl)amino]phenyl]acetoxy]acetic acid (China Patent No. CN111848426 A). European Patent Office.Patent No. CN111848426 A). https://worldwide.espacenet.com/patent/search/family/073001820/publication/CN111848426A?q=CN111848426%20A
dc.relation.referencesen31. Korea Biochem Pharm. Inc. (2020). Manufacturing method of aceclofenac and pharmaceutical preparations containing it (Korea Patent No. KR2020098992A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/072235748/publication/KR20200098992A?q=KR20200098992A
dc.relation.referencesen32. Zhejiang University of Technology (2019). Preparation method of aceclofenac (China Patent No. CN110143891 A). European Patent Office. https://worldwide.espacenet.com/patent/search/family/067592402/publication/CN110143891A?q=CN110143891%20A
dc.relation.referencesen33. Amoli Organics Pvt. Ltd. (2015). An improved process for preparation of [2-(2,6- dichloroanilino)phenyl]acetoxy acetic acid (India Patent No. IN2013MU00480 A).
dc.relation.referencesen34. Bisel, P., Al‐Momani, L. A., & Müller, M. (2008). The tert-butyl group in chemistry and biology. Organic and Biomolecular Chemistry, 6(15), 2655. https://doi.org/10.1039/b800083b
dc.relation.urihttps://doi.org/10.1002/3527608001
dc.relation.urihttps://ci.nii.ac.jp/ncid/BA04431981
dc.relation.urihttps://www.thepharmajournal.com/archives/2016/vol5issue3/PartA/5-1-7.pdf
dc.relation.urihttps://doi.org/10.1517/14656566.5.6.1347
dc.relation.urihttps://doi.org/10.2165/00003495-200161090-00012
dc.relation.urihttps://www.drugs.com/international/aceclofenac.html
dc.relation.urihttps://doi.org/10.1002/bmc.243
dc.relation.urihttps://doi.org/10.1016/b978-0-444-53717-1.00214-6
dc.relation.urihttps://doi.org/10.1016/s0928-0987(02)00011-8
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/044169183/publication/US2011229573A1?q=US%2020110229573A1
dc.relation.urihttps://doi.org/10.3797/scipharm.1202-12
dc.relation.urihttp://www.drlz.com.ua
dc.relation.urihttps://www.pharmacompass.com/listed-activepharmaceutical-ingredients/aceclofenac
dc.relation.urihttps://www.cas.org/solutions/cas-scifinder-discovery-platform/cas-scifinder
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/063071328/publication/CN108383745A?q=CN108383745A
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/067592402/publication/CN110143891A?q=CN110143891A
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/034814929/publication/WO2005073163A1?q=WO2005073163%20A1
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/008279093/publication/CA2111169A1?q=CA2111169A1
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/019554832/publication/KR20000026534A?q=KR20000026534A
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/019538371/publication/WO9962865A1?q=WO9962865%20A1
dc.relation.urihttp://nopr.niscair.res.in/bitstream/123456789/32833/1/JSIR%2074%2810%29%20582-583.pdf
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/039621763/publication/CN101215243A?q=CN101215243%20A
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/073001820/publication/CN111848426A?q=CN111848426%20A
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/072235748/publication/KR20200098992A?q=KR20200098992A
dc.relation.urihttps://worldwide.espacenet.com/patent/search/family/067592402/publication/CN110143891A?q=CN110143891%20A
dc.relation.urihttps://doi.org/10.1039/b800083b
dc.rights.holder© Національний університет “Львівська політехніка”, 2024
dc.subjectацеклофенак
dc.subjectсубстанція
dc.subject2-(трет-бутокси)-2-оксоетил-2-(2-((2
dc.subject6-дихлорфеніл)аміно) феніл)ацетат
dc.subjectтрифторацетатна кислота
dc.subjectкислотний гідроліз
dc.subjectоснови технології
dc.subjectтехнологічна схема
dc.subjectaceclofenac
dc.subjectsubstance
dc.subject2-(tert-butoxy)-2-oxoethyl-2-(2-((2
dc.subject6-dichlorophenyl) amino)-phenyl)acetate
dc.subjecttrifluoroacetic acid
dc.subjectacid hydrolysis
dc.subjectbasics of technology
dc.subjecttechnological scheme
dc.titleDevelopment of the technological basis for the production of aceclofenac
dc.title.alternativeРозроблення основ технології одержання ацеклофенаку
dc.typeArticle

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Chemistry, Technology and Application of Substances. – 2024. – Vol. 7, No. 1