Fundamentals of probiotic production technology based on Lactobacillus acidophilus strains

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dc.citation.epage118
dc.citation.issue2
dc.citation.journalTitleChemistry, Technology and Application of Substances
dc.citation.spage102
dc.contributor.affiliationНаціональний університет “Львівська політехніка”
dc.contributor.affiliationОпольський університет
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.affiliationUniversity of Opole
dc.contributor.authorВіхрова, А. О.
dc.contributor.authorКурка, М. С.
dc.contributor.authorЯсіцька-Місяк, І.
dc.contributor.authorБучкевич, І. Р.
dc.contributor.authorVikhrova, A. O.
dc.contributor.authorKurka, M. S.
dc.contributor.authorJasicka-Misiak, I.
dc.contributor.authorBuchkevych, I. R.
dc.coverage.placenameLviv
dc.coverage.placenameLviv
dc.date.accessioned2025-03-05T08:12:25Z
dc.date.created2023-02-28
dc.date.issued2023-02-28
dc.description.abstractРозроблено та спроєктовано виробництво пробіотичного препарату на основі антибіотико-резистентних штамів Lactobacillus acidophilus, який доцільно використовувати разом із антибіотикотерапією під час лікування різноманітних інфекцій для підтримання мікрофлори кишечника в нормі. Наведено якісну характеристику сировини, мікроорганізмів-продуцентів та кінцевого продукту. На основі матеріального балансу культивування, узгодженого із проєктною потужністю, підібрано технологічне обладнання відповідних параметрів, розроблено структурну технологічну схему виробництва пробіотика. Впровадження запропонованого виробництва пробіотичного препарату на основі Lactobacillus acidophilus дасть змогу розширити асортимент вітчизняних пробіотичних БАД на світовому ринку.
dc.description.abstractDesigned and engineered the production of a probiotic preparation based on antibiotic-resistant strains of Lactobacillus acidophilus, which is beneficial to use in conjunction with antibiotic therapy for the treatment of various types of infections to maintain normal intestinal microflora. Provided qualitative characteristics of the raw materials, producer microorganisms, and the final product. On the basis of the material balance of cultivation agreed with the design capacity, technological equipment of appropriate parameters was selected, a block diagram of the technological line and a technological scheme of probiotic production were developed. Implementation of the proposed production of a probiotic preparation based on Lactobacillus acidophilus will allow to expand the range of domestic probiotic dietary supplements.
dc.format.extent102-118
dc.format.pages17
dc.identifier.citationFundamentals of probiotic production technology based on Lactobacillus acidophilus strains / A. O. Vikhrova, M. S. Kurka, I. Jasicka-Misiak, I. R. Buchkevych // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 6. — No 2. — P. 102–118.
dc.identifier.citationenFundamentals of probiotic production technology based on Lactobacillus acidophilus strains / A. O. Vikhrova, M. S. Kurka, I. Jasicka-Misiak, I. R. Buchkevych // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 6. — No 2. — P. 102–118.
dc.identifier.doidoi.org/10.23939/ctas2023.02.102
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/63671
dc.language.isoen
dc.publisherLviv Politechnic Publishing House
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry, Technology and Application of Substances, 2 (6), 2023
dc.relation.ispartofChemistry, Technology and Application of Substances, 2 (6), 2023
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dc.relation.referencesen1. Hrncir, T. (2022). Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options. Microorganisms, 10(3), 578. https://doi.org/10.3390/microorganisms10030578
dc.relation.referencesen2. Hill, C., Guarner, F., Reid, G., Gibson, G. R., & Merenstein, D. J. (2014). Pot B6, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol, 11, 506-514. https://doi.org/10.1038/nrgastro.2014.66
dc.relation.referencesen3. Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., Verbeke, K., & Reid, G. (2017). Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology, 14(8), 491-502. https://doi.org/10.1038/nrgastro.2017.75
dc.relation.referencesen4. Office of Dietary Supplements - Probiotics. Office of Dietary Supplements (ODS). https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/.
dc.relation.referencesen5. Wilkins, T. (2017, August 1). Probiotics for Gastrointestinal Conditions: A Summary of the Evidence. Am Fam Physician, 96(3), 170-178. https://www.aafp.org/pubs/afp/issues/2017/0801/p170.html.
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dc.relation.referencesen8. Guerrero, C., & Illanes, A. (2016). Enzymatic production of other lactose-derived prebiotic candidates. In Lactose-Derived Prebiotics: A Process Perspective (pp. 229-259). Elsevier Inc. https://doi.org/10.1016/b978-0-12-802724-0.00006-8
dc.relation.referencesen9. Lactitol. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Lactitol#section=Structures.
dc.relation.referencesen10. Ingold, C. J. (2023, February 11). Simethicone. StatPearls - NCBI Bookshelf . https://www.ncbi.nlm.nih.gov/books/NBK555997/
dc.relation.referencesen11. Banwo, K., Adesina, T., Aribisala, O., & Falade, T. D. (2023). Detoxification of Aflatoxins in Fermented Cereal Gruel (Ogi) by Probiotic Lactic Acid Bacteria and Yeasts with Differences in Amino Acid Profiles. Toxins, 15(3), 210. https://doi.org/10.3390/toxins15030210
dc.relation.referencesen12. Wehrli, C. (1993, January 26). US5410056A - Method for the production of folic acid - Google Patents. https://patents.google.com/patent/US5410056A/en.
dc.relation.referencesen13. Folic Acid. (n.d.-a). PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Folic-Acid.
dc.relation.referencesen14. Office of Dietary Supplements - Vitamin B12. (n.d.). Office of Dietary Supplements (ODS). https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/.
dc.relation.referencesen15. Calvillo, Á., Pellicer, T., Carnicer, M., & Planas, A. (2022). Bioprocess Strategies for Vitamin B12 Production by Microbial Fermentation and Its Market Applications. Bioengineering, 9(8), 365. https://doi.org/10.3390/bioengineering9080365
dc.relation.referencesen16. Zhao Fugui. (2006, July 27). CN1887845A - Granular sodium benzoate and its production process - Google Patents. https://patents.google.com/patent/CN1887845A/en.
dc.relation.referencesen17. Bull, M., Plummer, S., Marchesi, J., & Mahenthiralingam, E. (2013). The life history of Lactobacillus acidophilus as a probiotic: a tale of revisionary taxonomy, misidentification and commercial success. FEMS microbiology letters, 349(2), 77-87. https://doi.org/10.1111/1574-6968.12293
dc.relation.referencesen18. Sapkota, A. (2021). Lactobacillus acidophilus-An Overview - Microbe Notes. https://microbenotes.com/lactobacillus-acidophilus/.
dc.relation.referencesen19. Oladipo, I. C., Anwooko, D. O., Daramola, D. I., Babalola, F. B., Abidoye, G. T., Olawale, O. D., ... & Olanbiwoninu, A. A. (2016). Bioprotective potential of bacteriocins from some Lactobacillus species isolated from foods. The Journal of Microbiology, Biotechnology and Food Sciences, 6(3), 900. https://doi.org/10.15414/jmbfs.2016/17.6.3.900-904
dc.relation.referencesen20. Taye, Y., Degu, T., Fesseha, H., & Mathewos, M. (2021). Isolation and identification of lactic acid bacteria from cow milk and milk products. The Scientific World Journal, 2021. https://doi.org/10.1155/2021/4697445
dc.relation.referencesen21. Islam, R., Hossain, M. N., Alam, M. K., Uddin, M. E., Rony, M. H., Imran, M. A. S., & Alam, M. F. (2020). Antibacterial activity of lactic acid bacteria and extraction of bacteriocin protein. Advances in Bioscience and Biotechnology, 11(02), 49-59. https://doi.org/10.4236/abb.2020.112004
dc.relation.referencesen22. Lactophore. Tabletki.ua. https://tabletki.ua/uk/Laktofor-10/1007446/
dc.relation.referencesen23. Zhai Guangxi. (2015, January 13). CN104610745A - Preparation method for simethicone - Google Patents. https://patents.google.com/patent/CN104610745A/en.
dc.relation.referencesen24. Hayek, S. A., Gyawali, R., Aljaloud, S. O., Krastanov, A., & Ibrahim, S. A. (2019). Cultivation media for lactic acid bacteria used in dairy products. Journal of Dairy Research, 86(4), 490-502. https://doi.org/10.1017/s002202991900075x
dc.relation.referencesen25. Federica.Ferrari. (2022). What is Rye Flour and How to Bake With It? https://www.finedininglovers.com/article/rye-flour-benefits-use.
dc.relation.referencesen26. Sydorov YU. I., Vlyazlo R. Y., Novikov V. s. (2008). Protsesy ta aparaty mikrobiolohichnoyi ta farmatsevtychnoyi promyslovosti. Lʹviv: Intelekt-Zakhid.
dc.relation.urihttps://doi.org/10.3390/microorganisms10030578
dc.relation.urihttps://doi.org/10.1038/nrgastro.2014.66
dc.relation.urihttps://doi.org/10.1038/nrgastro.2017.75
dc.relation.urihttps://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/
dc.relation.urihttps://www.aafp.org/pubs/afp/issues/2017/0801/p170.html
dc.relation.urihttps://apteka911.ua/ua/shop/dietichna-dobavka-dlya-regulyuvannya-mikrof..
dc.relation.urihttps://apteka911.ua/ua/shop/probiotiks-imuno-nova-formula-kaps-20-solut..
dc.relation.urihttps://doi.org/10.1016/b978-0-12-802724-0.00006-8
dc.relation.urihttps://pubchem.ncbi.nlm.nih.gov/compound/Lactitol#section=Structures
dc.relation.urihttps://www.ncbi.nlm.nih.gov/books/NBK555997/
dc.relation.urihttps://doi.org/10.3390/toxins15030210
dc.relation.urihttps://patents.google.com/patent/US5410056A/en
dc.relation.urihttps://pubchem.ncbi.nlm.nih.gov/compound/Folic-Acid
dc.relation.urihttps://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
dc.relation.urihttps://doi.org/10.3390/bioengineering9080365
dc.relation.urihttps://patents.google.com/patent/CN1887845A/en
dc.relation.urihttps://doi.org/10.1111/1574-6968.12293
dc.relation.urihttps://microbenotes.com/lactobacillus-acidophilus/
dc.relation.urihttps://doi.org/10.15414/jmbfs.2016/17.6.3.900-904
dc.relation.urihttps://doi.org/10.1155/2021/4697445
dc.relation.urihttps://doi.org/10.4236/abb.2020.112004
dc.relation.urihttps://tabletki.ua/uk/Лактофор-10/1007446/
dc.relation.urihttps://patents.google.com/patent/CN104610745A/en
dc.relation.urihttps://doi.org/10.1017/s002202991900075x
dc.relation.urihttps://www.finedininglovers.com/article/rye-flour-benefits-use
dc.rights.holder© Національний університет “Львівська політехніка”, 2023
dc.subjectLactobacillus acidophilus
dc.subjectкультивування
dc.subjectпоживне середовище
dc.subjectстерилізація
dc.subjectферментер
dc.subjectтехнологічна схема
dc.subjectLactobacillus acidophilus
dc.subjectcultivation
dc.subjectgrowth medium
dc.subjectsterilization
dc.subjectfermenter
dc.subjecttechnological scheme
dc.titleFundamentals of probiotic production technology based on Lactobacillus acidophilus strains
dc.title.alternativeТехнологія виробництва пробіотичного препарату на основі штамів Lactobacillus Acidophilus
dc.typeArticle

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Chemistry, Technology and Application of Substances. – 2023. – Vol. 6, No. 2