Characteristics of spray drying process of nanocolloidal silica as a method of production of nanostructural powders potentially applicable in inhalation therapy
| dc.citation.conference | Litteris et Artibus | |
| dc.contributor.affiliation | Warsaw University of Technology | uk_UA |
| dc.contributor.author | Jabłczyńska, Katarzyna | |
| dc.contributor.author | Wojnarowicz, Michał | |
| dc.contributor.author | Sosnowski, Tomasz R. | |
| dc.coverage.country | UA | uk_UA |
| dc.coverage.placename | Lviv | uk_UA |
| dc.date.accessioned | 2018-03-22T10:26:10Z | |
| dc.date.available | 2018-03-22T10:26:10Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | The research was focused on investigations of the impact of spray-drying (SD) conditions on the morphology and aerosol performance of powders produced from nanocolloidal silica. Microsized nanostructiral particles were characterized by SEM, aerosol spectrometry and pharmaceutical impactor. Results show that proper adjusting of SD process parameters and precursor composition allows to obtain powders of different morphologies: solid or hollow particles with different wall thickness, or particles with a microporous structure with spherical or nonspherical shape. Obtained results indicate that silica nanoagreggates have characteristics suitable for their effective delivery to the lungs via inhalation. | uk_UA |
| dc.format.pages | 366-371 | |
| dc.identifier.citation | Jabłczyńska K. Characteristics of spray drying process of nanocolloidal silica as a method of production of nanostructural powders potentially applicable in inhalation therapy / Katarzyna Jabłczyńska, Michał Wojnarowicz, Tomasz R. Sosnowski // Litteris et Artibus : proceedings of the 5th International youth science forum, November 26–28, 2015, Lviv, Ukraine / Lviv Polytechnic National University. – Lviv : Lviv Polytechnic Publishing House, 2015. – P. 366–371. – Bibliography: 11 titles. | uk_UA |
| dc.identifier.uri | https://ena.lpnu.ua/handle/ntb/39901 | |
| dc.language.iso | en | uk_UA |
| dc.publisher | Lviv Polytechnic Publishing House | uk_UA |
| dc.relation.referencesen | [1] M. M. Bailey, C. J. Berkland, “Nanoparticle formulation in pulmonary drug delivery”, Medicinal Research Review. Vol 29, No. 1. pp.196-212, 2008. [2] W. H. Roa, S. Azarm, M.H.D.K. Al-Hallak, W. H. Finlay, A. M. Magliocco, R. Löbenberg, “Inhalable nanoparticles, a non-invasive approach to treat lung cancer in a mouse model”, Journal of Controlled Release, Vol. 150, pp 49-55, 2011. [3] H. M. Mansour, Y. Rhee, X. Wu, “Nanomedicine in pulmonary delivery”, International Journal of Nanomedicine. Vol. 4, No. 4. pp. 299-319, 2009. [4] K.P. Lee, D.P. Kelly, “The pulmonary response and clearance of ludox colloidal silica after a 4-week inhalation exposure in rats”, Fundamental and Applied Toxicology, Vol. 19 (3) pp. 399–410, 1992. [5] K. Kho, K. Hadinoto, „Aqueous re-dispersibility characterization of spray-dried hollow spherical silica nano-aggregates,” Powder Technol. Vol. 198, pp. 354–363, 2010. [6] L Gradoń., T. R.Sosnowski, „Formation of particles for dry powder inhalers,” Adv. Powder Technol. Vol. 25, pp. 43–55, 2014. [7] J. C. Sung, B. L. Pulliam, D. A. Edwards, “Nanoparticles for drug delivery to the lungs”, TRENDS in Biotechnology, Vol. 25, No. 12, pp 563- 570, 2007. [8] K. Tomoda, T. Ohkoshia, K. Hirota, G. S. Sonavane, T. Nakajima, H. Terada, M. Komuro, K. Kitazato, K. Makino, “Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer”, Colloids and Surfaces B: Biointerfaces, Vol. 71, pp 177-182, 2009 [9] K. Hadinoto, P. Phanapavudhikul, Z. Kewu, R. B. H. Tan, „Novel Formulation of Large Hollow Nanoparticles Aggregates as Potential Carriers in Inhaled Delivery of Nanoparticulate Drugs,” Ind. Eng. Chem. Res. Vol. 45, pp. 3697-3706, 2006. [10] http://fiji.sc/Fiji [11] R. W. R. Vehring, D. Foss, Lechuga-Ballesteros, “Particle formation in spray drying”, Journal Aerosol Science Vol. 38 pp. 728-746, 2007. | uk_UA |
| dc.subject | spray drying | uk_UA |
| dc.subject | nanostructural powder | uk_UA |
| dc.subject | particles engineering | uk_UA |
| dc.subject | silica particles | uk_UA |
| dc.subject | inhalation therapy | uk_UA |
| dc.title | Characteristics of spray drying process of nanocolloidal silica as a method of production of nanostructural powders potentially applicable in inhalation therapy | uk_UA |
| dc.type | Conference Abstract | uk_UA |