Amphiphilic Esters of Pyromellitic Acid: Synthesis and Prospects of Applications

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dc.citation.epage90
dc.citation.issue1
dc.citation.journalTitleХімія та хімічна технологія
dc.citation.spage79
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.affiliationNorth Dakota State University
dc.contributor.authorDonchak, Volodymyr
dc.contributor.authorVoronov, Andriy
dc.contributor.authorBudishevska, Olha
dc.contributor.authorKohut, Ananiy
dc.contributor.authorStetsyshyn, Yuriy
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2026-03-30T09:18:36Z
dc.date.created2025-02-27
dc.date.issued2025-02-27
dc.description.abstractЦей огляд стосується амфіфільних діестерів і поверхнево-активних “геміні”-речовин, синтезованих із піромелітової кислоти, поліетиленгліколів, аліфатичних спиртів і холестеролу. Обговорення охоплює їхні унікальні колоїдні та хімічні властивості, з акцентом на взаємозв’язку між критичною концентрацією міцелоутворення (ККМ) і гідрофільно-ліпофільним балансом. Структурні фактори, зокрема довжина ліпофільних замісників, істотно впливають на значення ККМ у водних системах. Крім того, наявність карбоксильних груп у фрагменті піромелітинової кислоти дає змогу здійснювати рН-залежну модуляцію поверхневої активності. Описані амфіфільні речовини мають винятковий потенціал для формування міцелярних структур, здатних солюбілізувати гідрофобні речовини, зокрема барвники, олії, холестерол і біологічно активну речовину куркумін. Окрім підвищення стабільності цих речовин, вони забезпечують механізми контрольованого вивільнення, які імітують взаємодію із клітинною мембраною. Така універсальність дає змогу розглядати ці матеріали як перспективні кандидати для інноваційного застосування у цільових системах доставки ліків і як нанореактори для синтезу наночастинок срібла. Цей огляд підкреслює їхній потенціал у розвитку нанотехнологій і біомедичної інженерії.
dc.description.abstractThis review focuses on amphiphilic diesters and “gemini” surfactants synthesized from pyromellitic acid, polyethylene glycols, aliphatic alcohols, and cholesterol. The discussion encompasses their unique colloidal and chemical properties, with an emphasis on the relationship between critical micelle concentration and hydrophilic-lipophilic balance. Structural factors, particularly the length of the lipophilic substituents, significantly influence CMC values in aqueous systems. Additionally, the presence of carboxyl groups in the pyromellitic acid core allows for pH-dependent modulation of surface activity. The amphiphiles exhibit exceptional potential in forming micellar structures capable of solubilizing hydrophobic substances, including dyes, oils, cholesterol, and the bioactive compound curcumin. Beyond enhancing the stability of these substances, they enable controlled release mechanisms that mimic cellular membrane interactions. Such versatility positions the materials from amphiphilic diesters of pyromellitic acid as promising candidates for innovative applications in targeted drug delivery systems and as nanoreactors for synthesizing silver nanoparticles. This review underscores their potential in advancing nanotechnology and biomedical engineering.
dc.format.extent79-90
dc.format.pages12
dc.identifier.citationAmphiphilic Esters of Pyromellitic Acid: Synthesis and Prospects of Applications / Volodymyr Donchak, Andriy Voronov, Olha Budishevska, Ananiy Kohut, Yuriy Stetsyshyn // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2025. — Vol 19. — No 1. — P. 79–90.
dc.identifier.citationenAmphiphilic Esters of Pyromellitic Acid: Synthesis and Prospects of Applications / Volodymyr Donchak, Andriy Voronov, Olha Budishevska, Ananiy Kohut, Yuriy Stetsyshyn // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2025. — Vol 19. — No 1. — P. 79–90.
dc.identifier.doidoi.org/10.23939/chcht19.01.079
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/124840
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofХімія та хімічна технологія, 1 (19), 2024
dc.relation.ispartofChemistry & Chemical Technology, 1 (19), 2024
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dc.rights.holder© Національний університет “Львівська політехніка”, 2025
dc.rights.holder© Donchak V., Voronov A., Budishevska O., Kohut A., Stetsyshyn Y., 2025
dc.subjectпіромелітова кислота
dc.subjectпіромелітовий діангідрид
dc.subjectполіетиленгліколь
dc.subjectхолестерол
dc.subjectповерхнево-активні “геміні”-речовини
dc.subjectсолюбілізація
dc.subjectкуркумін
dc.subjectpyromellitic acid
dc.subjectpyromellitic dianhydride
dc.subjectpolyethylene glycol
dc.subjectcholesterol
dc.subjectgemini surfactants
dc.subjectsolubilization
dc.subjectcurcumin
dc.titleAmphiphilic Esters of Pyromellitic Acid: Synthesis and Prospects of Applications
dc.title.alternativeАмфіфільні естери піромелітової кислоти: синтез і перспективи застосування
dc.typeArticle

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Chemistry & Chemical Technology. – 2025. – Vol. 19, No. 1