Characterization, Antioxidant Activity, and In Silico Molecular Docking of Chitosan from Snail Shell Waste by Ultrasonic Technique

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dc.citation.epage132
dc.citation.issue1
dc.citation.spage126
dc.contributor.affiliationUniversity of Brawijaya
dc.contributor.affiliationAcademy Pharmacy of Surabaya
dc.contributor.authorUmarudin
dc.contributor.authorRahayu, Sri
dc.contributor.authorWidyarti, Sri
dc.contributor.authorWarsito
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2024-02-09T10:29:32Z
dc.date.available2024-02-09T10:29:32Z
dc.date.created2023-02-28
dc.date.issued2023-02-28
dc.description.abstractРавлики поширені в Індонезії, особливо в Кедірі, але черепашки равлика не мають комерційної цінності. У цій роботі описано характеристику й in vitro оцінку біоактивності хітозану з відходів черепашок равликів (хітозан-SSW), отриманого за допомогою ультразвукової методики, та проаналізовано потенціал хітозану як інгібітора рецепторів вільних радикалів за допомогою методу молекулярного докінгу in silico. Мета дослідження властивостей хітозану-SSW – аналіз вмісту води, білка та функціональних груп, а також молекулярної маси, розміру частинок, морфології, оцінки антиоксидантної активностімолекулярного докінгу in silico. Встановлено, що хітозан-SSW, отриманий за допомогою ультразвукової обробки, мав високий ступінь деацетилювання (DD) і високу молекулярну масу (MW). Встановлено характеристики хітозану-SSW: вміст води 0,43 %, вміст білка 1,59 %, молекулярна маса 2198 кДа, значення ступеня деацетилювання 79,50 %. Важливо, що хітозан-SSW мав високу антиоксидантну активність для потенційного зменшення вільних радикалів DPPH зі значенням IC50 2,44мкг/мл. Передбачається, що хітозан має потенціал як інгібітор ліпоксигенази, CYP2C9 і NADPH-оксидази.
dc.description.abstractSnails are often found in Indonesia, especially at Kediri, but the snail shell has no commercial value. This research report describes the characterization and antioxidant activity of chitosan from snail shell waste (chitosan-SSW) by ultrasonic technique and analyzes the potential of chitosan as an inhibitor of receptors of free radicals using an in silico molecular docking method. Characterization of chitosan-SSW was performed to analyze the content of water, protein, and functional groups as well as molecular weight, particle size, mor-phology, antioxidant activity, and in silico molecular docking. We found that chitosan-SSW with ultrasonic treatment had a high degree of deacetylation (DD) and high molecular weight (MW). The characteristic of chitosan-SSW was found to be as follows: water content of 0.43 %, protein content of 1.59 %, molecular weight of 2.198 kDa, and deacetylation degree value of 79.50 %. Importantly, chitosan-SSW had high antioxidant activity to potentially reduce free radical of DPPH with IC50 value of 2.44 µg/mL. Chitosan is predicted to have the potential as an inhibitor of lipoxygenase, CYP2C9, and NADPH-oxidase.
dc.format.extent126-132
dc.format.pages7
dc.identifier.citationCharacterization, Antioxidant Activity, and In Silico Molecular Docking of Chitosan from Snail Shell Waste by Ultrasonic Technique / Umarudin, Sri Rahayu, Sri Widyarti, Warsito // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 17. — No 1. — P. 126–132.
dc.identifier.citationenCharacterization, Antioxidant Activity, and In Silico Molecular Docking of Chitosan from Snail Shell Waste by Ultrasonic Technique / Umarudin, Sri Rahayu, Sri Widyarti, Warsito // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 17. — No 1. — P. 126–132.
dc.identifier.doidoi.org/10.23939/chcht17.01.126
dc.identifier.issn1196-4196
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/61212
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry & Chemical Technology, 1 (17), 2023
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dc.relation.referencesen[30] Srinivasan, H.; Kanayairam, V.; Ravichandran, R. Chitin and Chitosan Preparation from Shrimp Shells Penaeus Monodon and its Human Ovarian Cancer Cell Line, PA-1. Int. J. Biol. Macromol. 2018, 107, 662-667. https://doi.org/10.1016/j.ijbiomac.2017.09.035
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dc.relation.referencesen[32] Zhang, H.; Li, Y.; Zhang, X; Liu, B.; Zhao, H.; Chen, D. Directly Determining the Molecular Weight of Chitosan with Atomic Force Microscopy. Front Nanosci. Nanotech. 2016, 185, 57-63. https://doi.org/10.15761/FNN.1000121
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dc.rights.holder© Національний університет “Львівська політехніка”, 2023
dc.rights.holder© Umarudin, Rahayu S., Widyarti S., Warsito, 2023
dc.subjectхітозан-SSW
dc.subjectхарактеризація
dc.subjectультразвук
dc.subjectантиоксидант
dc.subjectin silico молекулярний докінг
dc.subjectchitosan-SSW
dc.subjectcharacterization
dc.subjectultrasound
dc.subjectantioxidant
dc.subjectin silico molecular docking
dc.titleCharacterization, Antioxidant Activity, and In Silico Molecular Docking of Chitosan from Snail Shell Waste by Ultrasonic Technique
dc.title.alternativeДослідження властивостей, антиоксидантна активність та in silico молекулярний докінг хітозану з відходів черепашок равлика за допомогою ультразвукової методикии
dc.typeArticle

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Chemistry & Chemical Technology. – 2023. – Vol. 17, No. 1