The Synthesis and In Silico Antihypertensive Activity Prognosis of New Mannich Bases Containing the 1,2,4-Triazole Moiety

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dc.citation.epage220
dc.citation.issue2
dc.citation.spage214
dc.citation.volume14
dc.contributor.affiliationNational University of Pharmacy
dc.contributor.affiliationDanylo Halytsky Lviv National Medical University
dc.contributor.affiliationLviv National Polytechnic University
dc.contributor.affiliationNational Academy of Medical Sciences
dc.contributor.affiliationNizhyn Mykola Gogol State University
dc.contributor.authorPerekhoda, Lina
dc.contributor.authorGeorgiyants, Victoria
dc.contributor.authorYeromina, Hanna
dc.contributor.authorDrapak, Iryna
dc.contributor.authorLubenets, Vira
dc.contributor.authorIeromina, Zinaida
dc.contributor.authorSych, Irina
dc.contributor.authorSeverina, Hanna
dc.contributor.authorDemchenko, Anatoly
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2020-12-30T08:53:17Z
dc.date.available2020-12-30T08:53:17Z
dc.date.created2020-01-24
dc.date.issued2020-01-24
dc.description.abstractУ рамках наших постійних досліджень щодо потенційних антигіпертензивних агентів серед похідних морфоліну та піперидину було розроблено та синтезовано 10 нових цільових сполук, що містять 1,2,4-тріазольний та морфоліновий або піперидиновий фрагменти. Проведені докінгові дослідження з метою пошуку біологічно активних речовин антигіпертензивної дії. Результати in silico досліджень свідчать, що всі синтезовані сполуки є перспективними інгібіторами ангіотензинперетворюючого ферменту і належать до 4 та 5 класів токсичності згідно класифікації OECР.
dc.description.abstractAs a part of our continuous research on potential antihypertensive agents among morpholine and piperidine derivatives, 10 novel target compounds containing 1,2,4-triazole and morpholine or piperidine moieties have been designed and synthesized, and the docking studies have been conducted in order to find biologically active substances with the antihypertensive activity. The in silico studies have shown that all compounds synthesized are promising angiotensin converting enzyme inhibitors and belong to the toxicity class 4 and 5 according to the classification of chemicals by the OECD project.
dc.format.extent214-220
dc.format.pages7
dc.identifier.citationThe Synthesis and In Silico Antihypertensive Activity Prognosis of New Mannich Bases Containing the 1,2,4-Triazole Moiety / Lina Perekhoda, Victoria Georgiyants, Hanna Yeromina, Iryna Drapak, Vira Lubenets, Zinaida Ieromina, Irina Sych, Hanna Severina, Anatoly Demchenko // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2020. — Vol 14. — No 2. — P. 214–220.
dc.identifier.citationenThe Synthesis and In Silico Antihypertensive Activity Prognosis of New Mannich Bases Containing the 1,2,4-Triazole Moiety / Lina Perekhoda, Victoria Georgiyants, Hanna Yeromina, Iryna Drapak, Vira Lubenets, Zinaida Ieromina, Irina Sych, Hanna Severina, Anatoly Demchenko // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2020. — Vol 14. — No 2. — P. 214–220.
dc.identifier.doidoi.org/10.23939/chcht14.02.214
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/55783
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry & Chemical Technology, 2 (14), 2020
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dc.relation.referencesen[3] Ueda Y., Timothy P., Wang I. et al., Pat. US 8461333 B2, Publ. Jun. 11, 2013.
dc.relation.referencesen[4] Yradjan M., Yradjan N., Paronykjan R., Stepanjan H., KhimikoFarmacevt. Zh., 2010, 44, 11.
dc.relation.referencesen[5] Klen E., Makarova N., Chalyullyn F. et al., Bashkirsky Khim. Zh., 2008, 15, 112.
dc.relation.referencesen[6]Jakhmola V., Jawla S., Mishra R., Acta Sci. Pharm. Sci., 2018, 2, 02.
dc.relation.referencesen[7] Al-Ghorbani M., Begum B. et al., J. Chem. Pharm. Res., 2015, 8, 611. https://doi.org/10.5958/0974-360X.2015.00100.6
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dc.relation.urihttps://doi.org/10.3897/pharmacia.66.e35083
dc.relation.urihttps://doi.org/10.5958/0974-360X.2015.00100.6
dc.relation.urihttps://doi.org/10.1002/med.21634
dc.relation.urihttps://doi.org/10.1016/j.ejmech.2019.05.056
dc.relation.urihttps://doi.org/10.1016/j.bmc.2015.09.034
dc.relation.urihttps://doi.org/10.3390/molecules23071559
dc.relation.urihttps://doi.org/10.1016/j.bmc.2013.10.017
dc.relation.urihttps://doi.org/10.2174/092986712803414213
dc.relation.urihttp://accelrys.com/
dc.relation.urihttp://www.way2drug.com/gusar/acutoxpredict.html
dc.relation.urihttps://doi.org/10.5958/0974-360X.2019.00846.1
dc.relation.urihttps://doi.org/10.1074/jbc.M110.167866
dc.relation.urihttps://doi.org/10.1021/ml4004588
dc.relation.urihttp://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformati
dc.rights.holder© Національний університет “Львівська політехніка”, 2020
dc.rights.holder© Perekhoda L., Georgiyants V., Yeromina H., Drapak I., Lubenets V., Ieromina Z., Sych I., Severina H., Demchenko A., 2020
dc.subjectоснови Манніха
dc.subject1
dc.subject2
dc.subject4-тріазол
dc.subjectсинтез
dc.subjectантигіпертензивна активність
dc.subjectпрогноз in silico
dc.subjectдокінгові дослідження
dc.subjectMannich bases
dc.subject1
dc.subject2
dc.subject4-triazole
dc.subjectsynthesis
dc.subjectantihypertensive activity
dc.subjectin silico prognosis
dc.subjectdocking studies
dc.titleThe Synthesis and In Silico Antihypertensive Activity Prognosis of New Mannich Bases Containing the 1,2,4-Triazole Moiety
dc.title.alternativeСинтез та in silico прогноз антигіпертензивної активності нових основ Манніха, що містять фрагмент 1,2,4-тріазолу
dc.typeArticle

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Chemistry & Chemical Technology. – 2020. – Vol. 14, No. 2