Synthesis and Antiplatelet Activites of Some Derivatives of p-Coumaric Acid

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dc.citation.epage302
dc.citation.issue3
dc.citation.spage296
dc.contributor.affiliationAirlangga University
dc.contributor.authorEkowati, Juni
dc.contributor.authorDiyah, Nuzul W.
dc.contributor.authorSyahrani, Achmad
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2020-03-02T13:09:29Z
dc.date.available2020-03-02T13:09:29Z
dc.date.created2019-02-28
dc.date.issued2019-02-28
dc.description.abstractСинтезовано нові похідні р-кумарової кис- лоти за участю реакцій алкілування, основного гідролізу, ка- талітичного гідрування та естерифікації Фішера. Всі реакції, за винятком каталітичного гідрування, проводились за допомогою мікрохвильового опромінення побутової мікрохвильової печі. За результатми аналізів на тромбоцити, враховуючи час згортання крові, показано, що р-кумарова кислота та її похідні мають антитромбоцитарну активність, яка пов'язана з ліпо- фільною природою сполук та їх спорідненістю з вибраною цільовою молекулою, тобто ферментом COX-1 (PDB ID 1CQE).
dc.description.abstractThe synthesis of new derivatives of pcoumaric acid was carried out through serial reactions, i.e. alkylating, base hydrolysis, catalytic hydrogenation, and Fisher esterification. All reactions except catalytic hydrogenation were conducted by utilizing microwave irradiation from a household microwave oven. The antiplatelet tests using clotting time showed that pcoumaric acid and its derivatives have antiplatelet activity which is related to the lipophilic nature of the compounds and its affinity with the selected target molecule, i.e. COX-1 enzyme (PDB ID 1CQE).
dc.format.extent296-302
dc.format.pages7
dc.identifier.citationEkowati J. Synthesis and Antiplatelet Activites of Some Derivatives of p-Coumaric Acid / Juni Ekowati, Nuzul W. Diyah, Achmad Syahrani // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2019. — Vol 13. — No 3. — P. 296–302.
dc.identifier.citationenEkowati J. Synthesis and Antiplatelet Activites of Some Derivatives of p-Coumaric Acid / Juni Ekowati, Nuzul W. Diyah, Achmad Syahrani // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2019. — Vol 13. — No 3. — P. 296–302.
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/46490
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry & Chemical Technology, 3 (13), 2019
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dc.relation.urihttps://doi.org/10.1111/jvim.12022
dc.relation.urihttps://doi.org/10.1213/ANE.0b013e318203f38d
dc.relation.urihttps://doi.org/10.1155/2015/607957
dc.relation.urihttps://doi.org/10.3390/molecules21080997
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dc.relation.urihttps://doi.org/10.4172/2161-
dc.relation.urihttps://doi.org/10.3390/ijms150915994
dc.relation.urihttps://doi.org/10.1039/b713985c
dc.relation.urihttps://doi.org/10.3906/kim-1110-8
dc.relation.urihttps://doi.org/10.1039/c2ob25462j
dc.relation.urihttps://doi.org/10.1021/ed300437k
dc.relation.urihttps://doi.org/10.4062/biomolther.2013.095
dc.relation.urihttps://doi.org/10.12921/cmst.2012.18.02.81-88
dc.relation.urihttps://doi.org/10.1161/01.HYP.0000258106.74139.25
dc.rights.holder© Національний університет „Львівська політехніка“, 2019
dc.rights.holder© Ekowati J., Diyah N., Syahrani A., 2019
dc.subjectр-кумарова кислота
dc.subjectантитромбоцитарний
dc.subjectCOX-1
dc.subjectчас згортання крові
dc.subjectкаталітичне гідрування
dc.subjectp-coumaric acid
dc.subjectantiplatelet
dc.subjectCOX-1
dc.subjectclotting time
dc.subjectcatalytic hydrogenation
dc.titleSynthesis and Antiplatelet Activites of Some Derivatives of p-Coumaric Acid
dc.title.alternativeСинтез і антитромбоцитарна дія деяких похідних p-кумарової кислоти
dc.typeArticle

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Chemistry & Chemical Technology. – 2019. – Vol. 13, No. 3