Correlation between IN SILICO and IN VITRO results of 1-(benzoyloxy)urea and its derivatives as potential anti-cancer drugs
dc.citation.epage | 24 | |
dc.citation.issue | 1 | |
dc.citation.spage | 19 | |
dc.citation.volume | 11 | |
dc.contributor.affiliation | Faculty of Pharmacy, Universitas Airlangga, Jl. Darmawangsa Dalam Surabaya 60282, Indonesia | |
dc.contributor.affiliation | Faculty of Science and Technology, Universitas Airlangga Surabaya, Indonesia | |
dc.contributor.author | Hardjono, Suko | |
dc.contributor.author | Siswodihardjo, Siswandono | |
dc.contributor.author | Pramono, Purwanto | |
dc.contributor.author | Darmanto, Win | |
dc.date.accessioned | 2018-06-20T12:59:12Z | |
dc.date.available | 2018-06-20T12:59:12Z | |
dc.date.created | 2017-01-20 | |
dc.date.issued | 2017-01-20 | |
dc.description.abstract | За модифікованою реакцією Шоттена- Баумана з додаванням хлористого бензоїлу або його гомологів до гідроксисечовини в тетрагідрофурані синтезовано 1-(бен- зоїлокси)сечовину та її похідні. Структуру синтезованих речовин підтверджено UV-Vis та інфрачервоною спектро- скопією, методами 1Н ЯМР, 13С ЯМР і мас-спектроскопією. Дослідження in silico стосовно протипухлинної активності 1- (бензоїлокси)сечовини та її похідних у ферменті рібонук- леотідредуктази (PDB:2EUD) проведено за допомогою програми Molegro. Протиракову активність за методом in vitro визначали за допомогою методу ММТ до колоній клітин HeLa. Показано, що результати in silico (Rerank Score) корелюють з результатами in vitro (log1/IC50). Визначено лінійну залежність між результатaми in silico та in vitro. | |
dc.description.abstract | 11-(Benzoyloxy)urea and its derivatives were synthesized by modified Scotten-Bauman reaction with adding benzoyl chloride or homologs to hydroxyurea in tetrahydrofuran. Structure characterization was conducted based on ultra-violet (UV-VIS) spectrum, infrared (FT-IR), H nucleus magnetic resonance (1H NMR), C nuclear magnetic resonance (13C NMR) and mass spectrometry (MS). In silico test to predict anti-cancer activity of 1-(benzoyloxy)urea and its derivatives in ribonucleotide reductase enzyme (PDB: 2EUD) was done using Molegro Program. The anti-cancer activity test was performed in vitro by using MTT method to HeLa cell lines. In silico test result (Rerank Score) was correlated relative to anti-cancer activity (log1/IC50). There was a significant linear relationship between in vitro and in silico anti-cancer activity. | |
dc.format.extent | 19-24 | |
dc.format.pages | 6 | |
dc.identifier.citation | Correlation between IN SILICO and IN VITRO results of 1-(benzoyloxy)urea and its derivatives as potential anti-cancer drugs / Suko Hardjono, Siswandono Siswodihardjo, Purwanto Pramono, Win Darmanto // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2017. — Vol 11. — No 1. — P. 19–24. | |
dc.identifier.citationen | Correlation between IN SILICO and IN VITRO results of 1-(benzoyloxy)urea and its derivatives as potential anti-cancer drugs / Suko Hardjono, Siswandono Siswodihardjo, Purwanto Pramono, Win Darmanto // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2017. — Vol 11. — No 1. — P. 19–24. | |
dc.identifier.uri | https://ena.lpnu.ua/handle/ntb/42071 | |
dc.language.iso | en | |
dc.publisher | Lviv Politechnic Publishing House | |
dc.relation.ispartof | Chemistry & Chemical Technology, 1 (11), 2017 | |
dc.relation.references | [1] www.depkes.go.id. | |
dc.relation.references | [2] http://www.depkes.go.id/resources/download/general/ Hasil%20 Riskesdas%202013.pdf.; 27/4/2015 | |
dc.relation.references | [3] Wiestler O., Haendler B. and Mumberg D.: Cancer Stem Cells, Novel Concepts and Prospects for Tumor Therapy, Ernst Schering Found. Symp. Proc., Germany, Berlin 2007. | |
dc.relation.references | [4] Navarra P. and Preziosi P.: Crit. Rev. Oncology/Hematology,1999, 29, 249. | |
dc.relation.references | [5] Khayat A., Guimaraes A., Cardoso P. et al.: Genet. Mol. Biol.,2004, 27, 115. | |
dc.relation.references | [6] Chabner B. and Calabresi P.: Chemotherapy of Neoplastic Diseases. [in:] Goodman&Gilman’s, The Pharmacological Basis of Therapeutics, 10th edn. McGraw-Hill, New York 2001, 1388-1445. | |
dc.relation.references | [7] http://www.komputasi.lipi.go.id. 16/12/2007. | |
dc.relation.references | [8] Jenzen F.: Introduction to Computational Chemistry, 2nd edn. Odense, Denmark 2007. | |
dc.relation.references | [9] Korolkovas A.: Essentials of Medicinal Chemistry, 2nd edn. John Wiley and Sons, New York, Singapore 1988. | |
dc.relation.references | [10] Topliss J.: J. Med. Chem, 1972, 15, 1006. | |
dc.relation.references | [11] Xu H., Faber C., Uchiki T. et.al.: PNAS, 2006, 103, 4028. | |
dc.relation.references | [12] Clayden J., Geeves N. and Warren S.: Organic Chemistry, 2nd edn. Oxford University Press, NY 2012. | |
dc.relation.references | [13] Zinner G. and Staffel R.: Arc. Pharm. Ber. Ges., 1969, 302,438. | |
dc.relation.references | [14] Siverstein R., Webster F. and Kiemle D.: Spectrofotometric Identification of Organic Compound, 7th edn. John Wiley and Sons Inc., NY 2005. | |
dc.relation.references | [15] http://ccrcfarmasiugm.wordpress.com/protokol. 20/3/2012. | |
dc.relation.references | [16] Hardjono S., Siswodihardjon S., Pramono P. and DarmantoW.: Curr. Drug Disc. Technol., 2016, 13, 101. | |
dc.relation.referencesen | [1] www.depkes.go.id. | |
dc.relation.referencesen | [2] http://www.depkes.go.id/resources/download/general/ Hasil%20 Riskesdas%202013.pdf.; 27/4/2015 | |
dc.relation.referencesen | [3] Wiestler O., Haendler B. and Mumberg D., Cancer Stem Cells, Novel Concepts and Prospects for Tumor Therapy, Ernst Schering Found. Symp. Proc., Germany, Berlin 2007. | |
dc.relation.referencesen | [4] Navarra P. and Preziosi P., Crit. Rev. Oncology/Hematology,1999, 29, 249. | |
dc.relation.referencesen | [5] Khayat A., Guimaraes A., Cardoso P. et al., Genet. Mol. Biol.,2004, 27, 115. | |
dc.relation.referencesen | [6] Chabner B. and Calabresi P., Chemotherapy of Neoplastic Diseases. [in:] Goodman&Gilman’s, The Pharmacological Basis of Therapeutics, 10th edn. McGraw-Hill, New York 2001, 1388-1445. | |
dc.relation.referencesen | [7] http://www.komputasi.lipi.go.id. 16/12/2007. | |
dc.relation.referencesen | [8] Jenzen F., Introduction to Computational Chemistry, 2nd edn. Odense, Denmark 2007. | |
dc.relation.referencesen | [9] Korolkovas A., Essentials of Medicinal Chemistry, 2nd edn. John Wiley and Sons, New York, Singapore 1988. | |
dc.relation.referencesen | [10] Topliss J., J. Med. Chem, 1972, 15, 1006. | |
dc.relation.referencesen | [11] Xu H., Faber C., Uchiki T. et.al., PNAS, 2006, 103, 4028. | |
dc.relation.referencesen | [12] Clayden J., Geeves N. and Warren S., Organic Chemistry, 2nd edn. Oxford University Press, NY 2012. | |
dc.relation.referencesen | [13] Zinner G. and Staffel R., Arc. Pharm. Ber. Ges., 1969, 302,438. | |
dc.relation.referencesen | [14] Siverstein R., Webster F. and Kiemle D., Spectrofotometric Identification of Organic Compound, 7th edn. John Wiley and Sons Inc., NY 2005. | |
dc.relation.referencesen | [15] http://ccrcfarmasiugm.wordpress.com/protokol. 20/3/2012. | |
dc.relation.referencesen | [16] Hardjono S., Siswodihardjon S., Pramono P. and DarmantoW., Curr. Drug Disc. Technol., 2016, 13, 101. | |
dc.relation.uri | http://www.depkes.go.id/resources/download/general/ | |
dc.relation.uri | http://www.komputasi.lipi.go.id | |
dc.relation.uri | http://ccrcfarmasiugm.wordpress.com/protokol | |
dc.rights.holder | © Національний університет „Львівська політехніка“, 2017 | |
dc.rights.holder | © Hardjono S., Siswodihardjo S., Pramono P., Darmanto W., 2017 | |
dc.subject | 1-(бензоїлокси)сечовина | |
dc.subject | похідні | |
dc.subject | in vitro | |
dc.subject | in silico | |
dc.subject | 1-(benzoyloxy)urea | |
dc.subject | derivatives | |
dc.subject | in silico test | |
dc.subject | in vitro test | |
dc.subject | rerank score | |
dc.title | Correlation between IN SILICO and IN VITRO results of 1-(benzoyloxy)urea and its derivatives as potential anti-cancer drugs | |
dc.title.alternative | Кореляція IN SILICO та IN VITRO результатів дослідження 1-(бензоїлокси)сечовини та її похідних як потенційних протиракових препаратів | |
dc.type | Article |
Files
License bundle
1 - 1 of 1