Chemical Analysis and the Study of Quality Indicators of the Immunobiological Drug for Preventing and Treating Candidal Infections

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dc.citation.epage462
dc.citation.issue4
dc.citation.spage455
dc.contributor.affiliationNational University of Pharmacy
dc.contributor.authorRybalkin, Mykola
dc.contributor.authorStrelnikov, Leonid
dc.contributor.authorStrilets, Oksana
dc.contributor.authorKaliuzhnaia, Olha
dc.contributor.authorKutsenko, Sergiy
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2023-12-13T10:02:58Z
dc.date.available2023-12-13T10:02:58Z
dc.date.created2010-03-16
dc.date.issued2010-03-16
dc.description.abstractВстановлено, що такі показники якості як вміст білка, вміст полісахариду, вміст фенолу та рН розробленого вакцинального розчину для ін’єкцій (ВРІ) "Кандидоцид" на основі клітин грибів C. albicans та C. tropicalis, відповідають стандартним вимогам. Визначено, що за показником прозорості та ступенем помутніння досліджуваний розчин є прозорим, за ступенем забарвлення – безбарвний, за показником стерильності – стерильний. Період стерильності, визначений після першого відкриття, становить 8 год. Встановлено, що у розчині відсутні тверді частинки; ємність з розчином герметична; об'єм ємності з розчином не менше 5,0 мл. Досліджуваний розчин є стабільним протягом 2 років зберігання за температури 275–265 К.
dc.description.abstractQuality indicators such as protein content, polysaccharide content, phenol content, and pH of the developed vaccine solution for injection (VSI) “Candidocyde” based on cells of C. albicans and C. tropicalis fungi have been found to meet the standard requirements. It was determined that by the indicator of transparency and degree of turbidity the test solution is transparent, by the coloration degree it is colorless, by the sterility indicator it is sterile. The sterility period, determined after the first opening, is 8 hours. It was found that no solid particles were present in the solution; the container with the solution is hermetic; the volume of the container with a solution is not less than 5.0 ml. The test solution is stable for 2 years of storage at 275-265 K.
dc.format.extent455-462
dc.format.pages8
dc.identifier.citationChemical Analysis and the Study of Quality Indicators of the Immunobiological Drug for Preventing and Treating Candidal Infections / Mykola Rybalkin, Leonid Strelnikov, Oksana Strilets, Olha Kaliuzhnaia, Sergiy Kutsenko // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2020. — Vol 14. — No 4. — P. 455–462.
dc.identifier.citationenChemical Analysis and the Study of Quality Indicators of the Immunobiological Drug for Preventing and Treating Candidal Infections / Mykola Rybalkin, Leonid Strelnikov, Oksana Strilets, Olha Kaliuzhnaia, Sergiy Kutsenko // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2020. — Vol 14. — No 4. — P. 455–462.
dc.identifier.doidoi.org/10.23939/chcht14.04.455
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/60573
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry & Chemical Technology, 4 (14), 2020
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dc.relation.referencesen[3] Mandelblat M., Frenkel M., Abbey D. et al., Mycoses, 2017, 60, 534. https://doi.org/10.1101/gr.174623.114
dc.relation.referencesen[4] Armstrong-James D., Meintjes G., Brown G., Trends Microbiol., 2014, 22, 120. https://doi.org/10.1016/j.tim.2014.01.001
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dc.relation.referencesen[6] Eliakim-Raz N., Babaoff R., Yahav D. et al., Int. J. Infect. Dis., 2016, 52, 49. https://doi.org/10.1016/j.ijid.2016.09.018
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dc.relation.referencesen[16] Gloria H.,Jose A., Norman P., Front. Immunol., 2018, 9, 897. https://doi.org/10.1172/JCI98685
dc.relation.referencesen[17] Portuondo D., Ferreira L., Urbaczek A. et al., Med. Mycol., 2015, 53, 69. https://doi.org/10.1093/mmy/myu045
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dc.relation.referencesen[19] Xiao-Juan W., Xue S., Lan Y. et al., Virulence, 2015, 4, 309. https://doi.org/10.4161/21505594.2014.983015
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dc.relation.referencesen[22] Yavorskiy V., Suchatskiy Y., Znak Z. et al., Chem. Chem. Technol., 2016, 10, 507. https://doi.org/10.23939/chcht10.04.507
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dc.relation.urihttps://doi.org/10.33891/fmicb.2018.00980
dc.relation.urihttps://doi.org/10.1590/S0036-46652015000500008
dc.relation.urihttps://doi.org/10.1101/gr.174623.114
dc.relation.urihttps://doi.org/10.1016/j.tim.2014.01.001
dc.relation.urihttps://doi.org/10.3390/pathogens5010006
dc.relation.urihttps://doi.org/10.1016/j.ijid.2016.09.018
dc.relation.urihttps://doi.org/10.3201/eid2302.152042
dc.relation.urihttps://doi.org/10.3390/jof4030097
dc.relation.urihttps://doi.org/10.3390/jof3040057
dc.relation.urihttps://doi.org/10.4155/fmc-2016-0051
dc.relation.urihttps://doi.org/0.1016/j.resmic.2015.02.009
dc.relation.urihttps://doi.org/10.1093/jac/dkv140
dc.relation.urihttps://doi.org/10.1016/j.coi.2012.04.007
dc.relation.urihttps://doi.org/10.1080/14787210.2017.1364992
dc.relation.urihttps://doi.org/10.1172/JCI98685
dc.relation.urihttps://doi.org/10.1093/mmy/myu045
dc.relation.urihttps://doi.org/10.1590/0074-02760150335
dc.relation.urihttps://doi.org/10.4161/21505594.2014.983015
dc.relation.urihttps://doi.org/10/31040/
dc.relation.urihttps://doi.org/10.23939/chcht11.04.475
dc.relation.urihttps://doi.org/10.23939/chcht10.04.507
dc.rights.holder© Національний університет “Львівська політехніка”, 2020
dc.rights.holder© Rybalkin M., Strelnikov L., Strilets O., Kaliuzhnaia O., Kutsenko S., 2020
dc.subjectвакцина
dc.subjectантиген
dc.subjectхімічний склад
dc.subjectбілки
dc.subjectполісахариди
dc.subjectvaccine
dc.subjectantigen
dc.subjectchemical composition
dc.subjectproteins
dc.subjectpolysaccharides
dc.titleChemical Analysis and the Study of Quality Indicators of the Immunobiological Drug for Preventing and Treating Candidal Infections
dc.title.alternativeХімічний аналіз і дослідження показників якості імунобіологічних ліків для профілактики і лікування кандидальних інфекцій
dc.typeArticle

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Chemistry & Chemical Technology. – 2020. – Vol. 14, No. 4