Strategies for the Synthesis of [1,2,4]Triazolo[1,5-a]pyridine-8-carbonitriles

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dc.citation.epage303
dc.citation.issue2
dc.citation.spage294
dc.contributor.affiliationTaras Shevchenko National University of Kyiv
dc.contributor.authorKhomenko, Dmytro
dc.contributor.authorShokol, Tetyana
dc.contributor.authorDoroshchuk, Roman
dc.contributor.authorRaspertova, Ilona
dc.contributor.authorLampeka, Rostyslav
dc.contributor.authorVolovenko, Yulian
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2024-02-12T08:30:45Z
dc.date.available2024-02-12T08:30:45Z
dc.date.created2023-03-16
dc.date.issued2023-03-16
dc.description.abstractКонденсовані гетероциклічні сполуки, що містять 1,2,4-триазольний цикл, становлять інтерес для науковців у зв’язку з їхнім широким застосуванням як у синтетичній, так і в медичній хімії. У цьому огляді вичерпно узагальнено методи синтезу [1,2,4]триазоло[1,5-a]піридин-8-карбонітрилів та класифіковано за типами використовуваних реагентів: перетворення 8-заміщених [1,2,4]триазоло[1,5-a]піридинів; синтези на основі функціоналізованих піридинів, що містять нітрильну групу; синтези на основі гетероциклізації 2-(1,2,4-триазол-5-іл) ацетонітрилів, ураховуючи циклоконденсації 2-(1,2,4-триазол-5-іл) ацетонітрилів з β-дикарбонільними сполуками та гетероциклізації 2-(1,2,4-триазол-5-іл)ацетонітрилів з α,β-ненасиченими нітрилами та естерами; циклоконденсації ациклічних реагентів, а саме похідних гідразину та заміщених метиленмалононітрилів або їхніх прекурсорів і рециклізацію солей оксадіазолопіридинію під дією аміаку або амінів.
dc.description.abstractConjugated heterocyclic compounds with a 1,2,4-triazole core are of scientific interest due to their wide application in both synthetic and medicinal chemistry. In this review, we comprehensively summarize the synthetic methods for [1,2,4]triazolo[1,5-a]pyridine-8-carbonitriles. The methods are classified as follows: convertion of 8-substituted [1,2,4]triazolo[1,5-a]pyridines; synthesis based on functionalized pyridines, containing a nitrile group; synthesis based on heterocyclization of 2-(1,2,4-triazol-5-yl) acetonitriles, including cyclocondensation of 2-(1,2,4-triazol-5-yl)acetonitriles with β-dicarbonyl compounds and heterocyclization of 2-(1,2,4-triazol-5-yl) acetonitriles with α,β-unsaturated nitriles and esters; cyclocondensation of acyclic reagents, namely hydrazine derivatives and substituted methylenemalononitriles or their precursors and recyclization of oxadiazolopyridinium salts upon the interaction with ammonia or amine.
dc.format.extent294-303
dc.format.pages10
dc.identifier.citationStrategies for the Synthesis of [1,2,4]Triazolo[1,5-a]pyridine-8-carbonitriles / Dmytro Khomenko, Tetyana Shokol, Roman Doroshchuk, Ilona Raspertova, Rostyslav Lampeka, Yulian Volovenko // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 17. — No 2. — P. 294–303.
dc.identifier.citationenStrategies for the Synthesis of [1,2,4]Triazolo[1,5-a]pyridine-8-carbonitriles / Dmytro Khomenko, Tetyana Shokol, Roman Doroshchuk, Ilona Raspertova, Rostyslav Lampeka, Yulian Volovenko // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2023. — Vol 17. — No 2. — P. 294–303.
dc.identifier.doidoi.org/10.23939/chcht17.02.294
dc.identifier.issn1996-4196
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/61258
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry & Chemical Technology, 2 (17), 2023
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dc.relation.referencesen[10] Ismail, M.M.F.; Khalifa, N.M.; Fahmy, H.H.; EL-Sahrawy, H.M.; Nossier, E.S. Anticancer Evaluation of Novel 1,3,4-Trisubstituted Pyrazole Candidates Bearing Different Nitrogenous Heterocyclic Moieties. Biomedical Research 2016, 27, 1087-1093.
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dc.rights.holder© Національний університет “Львівська політехніка”, 2023
dc.rights.holder© Khomenko D., Shokol T., Doroshchuk R., Raspertova I., Lampeka R., Volovenko Yu., 2023
dc.subjectамінопіридини
dc.subjectконденсація
dc.subjectпохідні гідразину
dc.subject[1
dc.subject2
dc.subject4]триазоло[1
dc.subject5-a]піридин-8-карбонітрили
dc.subject2-(1H-1
dc.subject2
dc.subject4-триазол-5-іл)ацетонітрил
dc.subjectaminopyridines
dc.subjectcondensation
dc.subjecthydrazine derivatives
dc.subject[1
dc.subject2
dc.subject4]triazolo[1
dc.subject5-a]pyridine-8-carbonitriles
dc.subject2-(1H-1
dc.subject2
dc.subject4-triazol-5-yl)acetonitrile
dc.titleStrategies for the Synthesis of [1,2,4]Triazolo[1,5-a]pyridine-8-carbonitriles
dc.title.alternativeСтратегії синтезу [1,2,4]триазоло [1,5-a]піридин-8-карбонітрилів
dc.typeArticle

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Chemistry & Chemical Technology. – 2023. – Vol. 17, No. 2