Synthesis, Structure and Properties of the Grafted Peptidomimetic Polymer Brushes Based on Poly(N-methacryloyl-L-proline)

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dc.citation.epage32
dc.citation.issue1
dc.citation.spage26
dc.contributor.affiliationLviv Polytechnic National University
dc.contributor.authorTokareva, Maria
dc.contributor.authorOhar, Halyna
dc.contributor.authorTokarev, Stanislav
dc.contributor.authorStetsyshyn, Yuriy
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2024-01-09T09:33:01Z
dc.date.available2024-01-09T09:33:01Z
dc.date.created2021-03-16
dc.date.issued2021-03-16
dc.description.abstractРозроблено новий підхід до синтезу на поверхні амінованого скла нових біологічно сумісних полімерних наношарів на основі полі(N-метакрилоїл-L-проліну). Процес формування полімерних наношарів проводили в декілька стадій. Спочатку поверхню скла модифікували аміносиланом АПТЕС, в подальшому до утвореного амінованого моношару прищеплювали пероксидовмісний ініціатор (ПІ) на основі піромелітової кислоти. Іммобілізований ПІ використовували для ініціювання прищеплювальної "від поверхні" радикальної полімеризації N-метакрилоїл-L-проліну для отримання пептидімітуючих полімерних щіток. У роботі висвітлено особливості перебігу реакції та оптимізовані умови її проведення. Наведені прищепленні покриття на основі щіток полі(N-метакрилоїл-Lпроліну) є багатообіцяючим матеріалом для багатьох застосувань у наномедицині, зокрема для створення імплантів та систем контрольованої взаємодії з білками та клітинами.
dc.description.abstractA new approach to synthesis at the aminated glass surface of novel biocompatible polymeric nanolayers consisting of poly(N-methacryloyl-L-proline) brushes has been developed. Formation of the polymer nanolayers has been realized in several stages. At the first stage, the glass surface has been modified by aminosilane (APTEC), afterwards monolayer of the peroxide containing initiator (PI) based on pyromellitic acid has been tethered to this aminated surface. The immobilized PI has been used further for initiation of the grafting "from the surface" polymerization of N-methacryloyl-L-proline for obtaining of the peptidomimetic polymer brushes. Features of the reactions, as well as optimal conditions for performing the process are highlighted in this work. Presented here poly(N-methacryloyl-L-proline) grafted brush coatings are promising material for numerous applications in nanomedicine, especially for production of implants and systems of the controlled interaction with proteins and cells.
dc.format.extent26-32
dc.format.pages7
dc.identifier.citationSynthesis, Structure and Properties of the Grafted Peptidomimetic Polymer Brushes Based on Poly(N-methacryloyl-L-proline) / Maria Tokareva, Halyna Ohar, Stanislav Tokarev, Yuriy Stetsyshyn // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2021. — Vol 15. — No 1. — P. 26–32.
dc.identifier.citationenSynthesis, Structure and Properties of the Grafted Peptidomimetic Polymer Brushes Based on Poly(N-methacryloyl-L-proline) / Maria Tokareva, Halyna Ohar, Stanislav Tokarev, Yuriy Stetsyshyn // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2021. — Vol 15. — No 1. — P. 26–32.
dc.identifier.doidoi.org/10.23939/chcht15.01.026
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/60702
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry & Chemical Technology, 1 (15), 2021
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dc.relation.referencesen[1] Motornov M., Roiter Y., Tokarev I., Minko S., Prog. Polym. Sci., 2010, 35, 174. https://doi.org/10.1016/j.progpolymsci.2009.10.004
dc.relation.referencesen[2] Tokarev I., Gopishetty V., Zhou J. et al., Appl. Mater. Interfaces, 2009, 1, 532. https://doi.org/10.1021/am800251a
dc.relation.referencesen[3] Lee H., Pietrasik J., Sheiko S., Matyjaszewski K., Prog. Polym. Sci., 2010, 35, 24. https://doi.org/10.1016/j.progpolymsci.2009.11.002
dc.relation.referencesen[4] Cole M., Voelcker N., Thissen H., Griesser H., Biomaterials, 2009, 30, 1827. https://doi.org/10.1016/j.biomaterials.2008.12.026
dc.relation.referencesen[5] Chen T., Ferris R., Zhang J. et al., Prog. Polym. Sci., 2010, 35, 94. https://doi.org/10.1016/j.progpolymsci.2009.11.004
dc.relation.referencesen[6] Synytska A., Svetushkina E., Puretskiy N. et al., Soft Matter, 2010, 6, 5907. https://doi.org/10.1039/P.0SM00414F
dc.relation.referencesen[7] Luzinov I., Minko S., Tsukruk V., Soft Matter, 2008, 4, 714. https://doi.org/10.1039/B718999K
dc.relation.referencesen[8] Fournier D., Hoogenboom R., Thijs H. et al., Macromolecules, 2007, 40, 915. https://doi.org/10.1021/ma062199r
dc.relation.referencesen[9] Chen G., Hoffman A., Nature, 1995, 373, 49. https://doi.org/10.1038/373049a0
dc.relation.referencesen[10] Lee H., Pietrasik J., Matyjaszewski K., Macromolecules, 2006, 39, 3914. https://doi.org/10.1021/ma060350r
dc.relation.referencesen[11] Zhang J., Peppas N., Macromolecules, 2000, 33, 102. https://doi.org/10.1021/ma991398q
dc.relation.referencesen[12] Garcia A., Marquez M., Cai T. et al., Langmuir, 2007, 23, 224. https://doi.org/10.1021/la061632n
dc.relation.referencesen[13] Burkert S., Bittrich E., Kuntzsch M. et al., Langmuir, 2010, 26, 1786. https://doi.org/10.1021/la902505q
dc.relation.referencesen[14] Mori H., Kato I., Endo T., Macromolecules, 2009, 42, 4985. https://doi.org/10.1021/ma900706s
dc.relation.referencesen[15] Mori H., Iwaya H., Nagai A., Endo T., Chem. Commun., 2005, 38, 4872. https://doi.org/10.1039/B509212D
dc.relation.referencesen[16] Mori H., Iwaya H., Endo T., React. Funct. Polym., 2007, 67, 916. https://doi.org/10.1016/j.reactfunctpolym.2007.05.016
dc.relation.referencesen[17] Mori H., Iwaya H., Endo T., Macromol. Chem. Phys, 2007, 208, 1908. https://doi.org/10.1021/ma902002b
dc.relation.referencesen[18] Mori H., Kato I., Matsuyama M., Endo T., Macromolecules , 2008, 41, 5604. https://doi.org/10.1021/ma800181h
dc.relation.referencesen[19] Sanda F., Endo T., Macromol. Chem. Phys., 1999, 200, 2651. https://doi.org/10.1002/(SICI)1521-3935(19991201)200:12<2651::AID-MACP2651>3.0.CO;2-P
dc.relation.referencesen[20] Mori H., Endo T., Macromol. Rapid Commun., 2012, 33, 1090. https://doi.org/10.1021/ma0509558
dc.relation.referencesen[21] Chung I., Britt P., Xie D. et al., Chem. Commun., 2005, 28, 1046. https://doi.org/10.1039/B416591H
dc.relation.referencesen[22] Liu Z., Hu J., Sun J. et al.:J. Polym. Sci. A, 2010, 48, 3573. https://doi.org/10.1002/pola.24137
dc.relation.referencesen[23] Katakai R., Yoshida M., Hasegawa S. et al., Macromolecules, 1996, 29, 1065. https://doi.org/10.1021/ma951094d
dc.relation.referencesen[24] Katakai R., Saito K., Sorimachi M et al., Macromolecules, 1998, 31, 3383. https://doi.org/10.1021/ma971727j
dc.relation.referencesen[25] Raczkowska J., Ohar M., Stetsyshyn Y. et al., Colloid. Surface B, 2014, 118, 270. https://doi.org/10.1016/j.colsurfb.2014.03.049
dc.relation.referencesen[26] Stetsyshyn Y., Raczkowska J., Budkowski A. et al., Langmuir, 2016, 32, 11029. https://doi.org/10.1021/acs.langmuir.6b02946
dc.relation.referencesen[27] Raczkowska J., Stetsyshyn Y., Awsiuk K. et al., Appl. Surf. Sci., 2017, 407, 546. https://doi.org/10.1016/j.apsusc.2017.03.001
dc.relation.referencesen[28] Riddick J.,. Bunger W, Sakano T., Weissenerger A., Organic Solvents: Physical Properties and Methods of Purification. Wiley, New York 1986.
dc.relation.referencesen[29] Milas N., Surgenor D., Am J. Chem. Soc, 1946, 68, 205. https://doi.org/10.1021/ja01206a017
dc.relation.referencesen[30] Bentolila A., Vlodavsky I., Ishai-Michaeli R.. et al.:J. Med. Chem, 2000, 43, 2591. https://doi.org/10.1021/jm000089j
dc.relation.referencesen[31] Bayer O., Houben J., Muller E., Methoden der organischen Chemie (Houben-Weyl), G. Thieme, Stuttgart, 1952, 8, 464.
dc.relation.referencesen[32] Wang X., Gan H., Zhang M., Sun T., Langmuir, 2012, 28, 2791. https://doi.org/10.1021/la204143g
dc.relation.referencesen[33] Cassie A., Discuss. Faraday Soc, 1948, 3, 11. https://doi.org/10.1039/DF9480300011
dc.relation.referencesen[34] Swain P., LipowskyR., Langmuir, 1998, 14, 6772. https://doi.org/10.1021/la980602k
dc.relation.referencesen[35] Bootsma G., Meyer F., Surf. Sci, 1969, 14, 52. https://doi.org/10.1016/0039-6028(69)90045-4
dc.relation.referencesen[36] Voronov S., Varvarenko S., Peroksydovani Makromolekuly na Mezhi Rozdilu Faz. Vyd-vo LPNU, Lviv 2011.
dc.relation.urihttps://doi.org/10.1016/j.progpolymsci.2009.10.004
dc.relation.urihttps://doi.org/10.1021/am800251a
dc.relation.urihttps://doi.org/10.1016/j.progpolymsci.2009.11.002
dc.relation.urihttps://doi.org/10.1016/j.biomaterials.2008.12.026
dc.relation.urihttps://doi.org/10.1016/j.progpolymsci.2009.11.004
dc.relation.urihttps://doi.org/10.1039/C0SM00414F
dc.relation.urihttps://doi.org/10.1039/B718999K
dc.relation.urihttps://doi.org/10.1021/ma062199r
dc.relation.urihttps://doi.org/10.1038/373049a0
dc.relation.urihttps://doi.org/10.1021/ma060350r
dc.relation.urihttps://doi.org/10.1021/ma991398q
dc.relation.urihttps://doi.org/10.1021/la061632n
dc.relation.urihttps://doi.org/10.1021/la902505q
dc.relation.urihttps://doi.org/10.1021/ma900706s
dc.relation.urihttps://doi.org/10.1039/B509212D
dc.relation.urihttps://doi.org/10.1016/j.reactfunctpolym.2007.05.016
dc.relation.urihttps://doi.org/10.1021/ma902002b
dc.relation.urihttps://doi.org/10.1021/ma800181h
dc.relation.urihttps://doi.org/10.1002/(SICI)1521-3935(19991201)200:12<2651::AID-MACP2651>3.0.CO;2-P
dc.relation.urihttps://doi.org/10.1021/ma0509558
dc.relation.urihttps://doi.org/10.1039/B416591H
dc.relation.urihttps://doi.org/10.1002/pola.24137
dc.relation.urihttps://doi.org/10.1021/ma951094d
dc.relation.urihttps://doi.org/10.1021/ma971727j
dc.relation.urihttps://doi.org/10.1016/j.colsurfb.2014.03.049
dc.relation.urihttps://doi.org/10.1021/acs.langmuir.6b02946
dc.relation.urihttps://doi.org/10.1016/j.apsusc.2017.03.001
dc.relation.urihttps://doi.org/10.1021/ja01206a017
dc.relation.urihttps://doi.org/10.1021/jm000089j
dc.relation.urihttps://doi.org/10.1021/la204143g
dc.relation.urihttps://doi.org/10.1039/DF9480300011
dc.relation.urihttps://doi.org/10.1021/la980602k
dc.relation.urihttps://doi.org/10.1016/0039-6028(69)90045-4
dc.rights.holder© Національний університет “Львівська політехніка”, 2021
dc.rights.holder© Tokareva M., Ohar H., Tokarev S., Stetsyshyn Y., 2021
dc.subjectсинтез полімерних наношарів
dc.subjectприщеплювальна "від поверхні" полімеризація
dc.subjectполімерні щітки
dc.subjectполі(N-метакрилоїл-L-пролін)
dc.subjectмодифікація поверхні
dc.subjectsynthesis of polymer nanolayers
dc.subject“grafting from” polymerization
dc.subjectpolymer brushes
dc.subjectpoly(N-methacryloyl-L-proline)
dc.subjectsurface modification
dc.titleSynthesis, Structure and Properties of the Grafted Peptidomimetic Polymer Brushes Based on Poly(N-methacryloyl-L-proline)
dc.title.alternativeСинтез, структура і властивості прищеплених полімерних щіток на основі полі(N-метакрилоїл-L-проліну)
dc.typeArticle

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Chemistry & Chemical Technology. – 2021. – Vol. 15, No. 1