The Synthesis and Theoretical Anti-Tumor Studies of Some New Monoaza-10H-Phenothiazine and 10H-Phenoxazine Heterocycles

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dc.citation.epage295
dc.citation.issue3
dc.citation.spage288
dc.contributor.affiliationUniversity of Nigeria
dc.contributor.authorOnoabedje, Efeturi A.
dc.contributor.authorOkafor, Sunday N.
dc.contributor.authorAkpomie, Kovo G.
dc.contributor.authorOkoro, Uchechukwu C.
dc.coverage.placenameЛьвів
dc.coverage.placenameLviv
dc.date.accessioned2020-03-02T13:09:28Z
dc.date.available2020-03-02T13:09:28Z
dc.date.created2019-02-28
dc.date.issued2019-02-28
dc.description.abstractСинтезовано ряд нових 3-амінопохідних 3-хлор-10Н-піридо[3,2-b][1,4]бензоксазину та 3-хлор-10H- піридо[3,2-b][1,4]бензотіазину та визначено їх протипухлинну активність. Синтезовані сполуки проаналізовані УФ-, 1H ЯМР-спектроскопією, спектроскопією Фур’є та елемент- ним аналізом. На основі фізико-хімічних властивостей за методом in silico виявлено, що проміжні продукти 3-хлор-10Н- піридо[3,2-b][1,4]бензоксазину і 3-хлор-10H-піридо[3,2-b] [1,4]бензотіазину, та їх карбоксиамідні похідні не порушують правила Ліпінського. За допомогою молекулярного докінгу показано, що синтезовані сполуки непогано взаємодіють з ре- цепторами раку. Визначено, що найвищу протипухлинну активність має 1,3-ді-10H-піридо[3,2-b][1,4]бензотіазин-3-ілсечовина.
dc.description.abstractThe synthesis and anticancer activity of a series of new 3-amido derivatives of 3-chloro-10Hpyrido[ 3,2-b][1,4]benzoxazine and 3-chloro-10H-pyrido [3,2-b][1,4]benzothiazine is presented. The synthesized structures were characterized by UV-visible, FT-IR, 1H NMR spectroscopy and elemental analytical data. The in silico physicochemical properties disclosed that neither 3-chloro-10H-pyrido[3,2-b][1,4]benzoxazine and 3-chloro- 10H-pyrido[3,2-b][1,4]benzothiazine intermediates nor their carboxyamido derivatives violate Lipinski’s rule of five. In addition, molecular docking studies showed that they exhibited good interaction with cancer receptors. 1,3-di-10H-Pyrido[3,2-b][1,4]benzothiazin-3-ylurea which showed a significant interaction with all the employed receptors possessed the highest anticancer activity.
dc.format.extent288-295
dc.format.pages8
dc.identifier.citationThe Synthesis and Theoretical Anti-Tumor Studies of Some New Monoaza-10H-Phenothiazine and 10H-Phenoxazine Heterocycles / Efeturi A. Onoabedje, Sunday N. Okafor, Kovo G. Akpomie, Uchechukwu C. Okoro // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2019. — Vol 13. — No 3. — P. 288–295.
dc.identifier.citationenThe Synthesis and Theoretical Anti-Tumor Studies of Some New Monoaza-10H-Phenothiazine and 10H-Phenoxazine Heterocycles / Efeturi A. Onoabedje, Sunday N. Okafor, Kovo G. Akpomie, Uchechukwu C. Okoro // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2019. — Vol 13. — No 3. — P. 288–295.
dc.identifier.urihttps://ena.lpnu.ua/handle/ntb/46489
dc.language.isoen
dc.publisherВидавництво Львівської політехніки
dc.publisherLviv Politechnic Publishing House
dc.relation.ispartofChemistry & Chemical Technology, 3 (13), 2019
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dc.relation.urihttps://doi.org/10.1016/j.phrs.2003.07.014
dc.relation.urihttps://doi.org/10.1371/journal.pone.0163467
dc.relation.urihttps://doi.org/10.1186/s13065-016-0148-1
dc.relation.urihttps://doi.org/10.1016/j.tet.2009.04.096
dc.relation.urihttps://doi.org/10.1021/ol801285g
dc.relation.urihttps://doi.org/10.1021/ol005654r
dc.relation.urihttps://doi.org/10.1074/jbc.M110.125161
dc.relation.urihttps://doi.org/10.1158/0008-5472.CAN-10-2101
dc.relation.urihttps://doi.org/10.1002/j.1460-2075.1990.tb07409.x
dc.relation.urihttps://doi.org/10.1021/jm011072j
dc.relation.urihttps://doi.org/10.1016/j.bmcl.2011.01.071
dc.relation.urihttps://doi.org/10.1016/j.bbamcr.2007.01.012
dc.relation.urihttps://doi.org/10.1186/1758-2946-3-33
dc.relation.urihttps://doi.org/10.1002/jcc.21256
dc.relation.urihttps://doi.org/10.1002/jcc.21334
dc.relation.urihttps://doi.org/10.1002/jhet.5570200441
dc.relation.urihttps://doi.org/10.1002/jhet.5570180820
dc.relation.urihttps://doi.org/10.1021/jm020017n
dc.rights.holder© Національний університет „Львівська політехніка“, 2019
dc.rights.holder© Onoabedje E., Okafor S., Akpomie K., Okoro U., 2019
dc.subjectсинтез
dc.subjectфеноксазин
dc.subjectфенотіазин
dc.subjectкарбоксиамід
dc.subjectпротипухлинні засоби
dc.subjectдокінг
dc.subjectsynthesis
dc.subjectphenoxazine
dc.subjectphenothiazine
dc.subjectcarboxyamide
dc.subjectanticancer
dc.subjectdocking
dc.titleThe Synthesis and Theoretical Anti-Tumor Studies of Some New Monoaza-10H-Phenothiazine and 10H-Phenoxazine Heterocycles
dc.title.alternativeСинтез і теоретичні протипухлинні дослідження деяких нових моноаза-10Н-фенотиазинових та 10Н- феноксазинових гетероциклів
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Chemistry & Chemical Technology. – 2019. – Vol. 13, No. 3