One-pot synthesis, antioxidant activity and toxicity evaluation of some hydroxyxanthones
Date
2018-01-20
Journal Title
Journal ISSN
Volume Title
Publisher
Lviv Politechnic Publishing House
Abstract
За допомогою одностадійої реакції цикло-
дегідрування похідних гідроксибензенової кислоти (саліцилова
або резорцилова кислота) з флороглюціном або пірогалолом у
присутності реагенту Ітона (P2O5/MeSO3H) одержано нові
сполуки гідроксиксантону. Для визначення інгібуючої
концентрації (IC50) синтезованих сполук їх антиокиснювальну
активність перевірено за допомогою 2,2-дифеніл-1-пікрилгід-
разилу. Цитотоксичність отриманих сполук оцінено MТT-
тестом на лінії клітин Vero. Встановлено, що положення та
кількість гідроксильних груп можуть суттєво вплинути на
потенційну антиокиснювальну активність приготовлених
сполук. Показано, що синтезовані сполуки гідроксиксантону
можна класифікувати як сильні антиоксиданти та їх можна
використовувати в промисловості.
Some new hydroxyxanthone compounds were prepared through one pot cyclodehydration reaction of hydroxybenzoic acid derivatives (salicylic acid or resorcylic acid) with phloroglucinol or pyrogallol in the presence of Eaton’s reagent (P2O5/MeSO3H). The synthesized compounds were screened for their antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods to determine their inhibitory concentration (IC50). Cytotoxicity of the prepared compounds was also evaluated by MMT assay on Vero cell line. It was observed that the position and the number of hydroxyl groups could significantly affect the potent antioxidant activity of the prepared compounds. Cytotoxicity evaluation of new compounds indicated that the synthesized series of hydroxyl xanthone were categorized as very strong antioxidants and showed potential development as a commercial antioxidant compound.
Some new hydroxyxanthone compounds were prepared through one pot cyclodehydration reaction of hydroxybenzoic acid derivatives (salicylic acid or resorcylic acid) with phloroglucinol or pyrogallol in the presence of Eaton’s reagent (P2O5/MeSO3H). The synthesized compounds were screened for their antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods to determine their inhibitory concentration (IC50). Cytotoxicity of the prepared compounds was also evaluated by MMT assay on Vero cell line. It was observed that the position and the number of hydroxyl groups could significantly affect the potent antioxidant activity of the prepared compounds. Cytotoxicity evaluation of new compounds indicated that the synthesized series of hydroxyl xanthone were categorized as very strong antioxidants and showed potential development as a commercial antioxidant compound.
Description
Keywords
антиоксидант, гідроксиксантони, 2, 2- дифеніл-1-пікрилгідразил, реагент Ітона, antioxidant, hydroxyxanthones, 2, 2-diphenyl- 1-picrylhydrazyl assay, Eaton’s reagent
Citation
One-pot synthesis, antioxidant activity and toxicity evaluation of some hydroxyxanthones / Emmy Yuanita, Harno Dwi Pranowo, Dwi Siswanta, Respati Tri Swasono, Mustofa, Abdul Karim Zulkarnain, Jufrizal Syahri, Jumina // Chemistry & Chemical Technology. — Lviv : Lviv Politechnic Publishing House, 2018. — Vol 12. — No 3. — P. 290–295.